Sudden infant deaths: stress, arousal and SIDS

Kahn, André; Groswasser, José; Franco, Patricia; Scaillet, Sonia; Sawaguchi, Toshiko; Kelmanson, Igor A.; Dan, Bernard

doi:10.1016/j.pathophys.2004.01.017

Cited by 27 publications

(38 citation statements)

References 57 publications

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“…27 As for sleep quality, they may also need education that although prone and side-sleeping infants do sleep longer than supine sleeping infants, this may be the result of fewer spontaneous arousals which may be protective of SIDS. 28 The use of positioning devices is discouraged; 29 however, a third of the mothers in this study were using such methods to maintain the infant's sleep position. As far as the authors are aware, only one sleep position device available in New Zealand has been subject to a safety trial, 30 but even then it should be strictly used according to instructions, and has not yet been shown to be effective as a treatment for head shape deformation, nor for its prevention.…”

Section: Discussionmentioning

confidence: 90%

Infant sleep position, head shape concerns, and sleep positioning devices

Hutchison¹,

Stewart

Mitchell³

2007

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 90%

Infant sleep position, head shape concerns, and sleep positioning devices

Hutchison¹,

Stewart

Mitchell³

2007

J Paediatrics Child Health

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“…A failure of the thermoregulatory feeding mechanism by which arousal is mediated, due to depletion of the calorigenic fat stores in BAT tissue (17) [as observed in newborns with cold injury or hypothermia (18)] or during hypoxia, could lead to malnourishment or, in the most extreme case, fatal events. It is well established that infants at risk of sudden infant death syndrome show a relatively poor ability to arouse from sleep (19).…”

Section: Discussionmentioning

confidence: 99%

Thermoregulatory Control of Feeding and Sleep in Premature Infants

Chardon¹,

Cardot²,

Léké

et al. 2006

Obesity

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CHARDON, KAREN, VIRGINIE CARDOT, ANDRÉ LÉ KÉ , STÉ PHANE DELANAUD, VÉ RONIQUE BACH, GÉ RARD DEWASMES, AND FRÉ DÉ RIC TELLIEZ. Thermoregulatory control of feeding and sleep in premature infants. Obesity. 2006;14:1535-1542. Objective: The aim of the present study was to test the thermoregulatory feeding control hypothesis in sleeping, premature infants. Research Methods and Procedures:In premature infants, the energy supply from food intake is crucial for (in order of importance): organ operation, body homeothermia, and optimal growth. The Himms-Hagen model of thermoregulatory feeding control involving activation of heat production by brown adipose tissue (BAT) was formulated on the basis of work in (awake) rats. This hypothesis has also been put forward for the human neonate, which can also use BAT to produce metabolic heat. According to the model, feeding episodes occur during a transient increase in body temperature. Feeding is initiated by a dip in blood glucose concentration after sugar uptake by activated BAT. Results: In 14 neonates (bottle-fed on demand), food intake always took place during an increase in skin temperature (ϩ0.19 Ϯ 0.21°C). Awakening occurred 18 Ϯ 17 minutes after the minimum skin temperature level had been reached. When feeding time was imposed, feeding was not necessarily situated during an increase in skin temperature, and the sleep duration after food intake increased significantly (ϩ43%). This could be considered as an adaptive response to the short-term sleep deprivation and/or stress elicited by an imposed feeding rhythm. Discussion: The validity of the model supports the use of on-demand feeding in neonatal care units, in accordance with the infant's physiological body temperature oscillations.

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“…SIDS is a multifactorial condition thought to be caused by abnormalities in the control of the heart, breathing, autonomic nervous system, and patterns of arousal during sleep. Physiological studies suggest that there may be a delay in the maturation of the autonomic nervous system, which results in a decreased propensity to arouse from sleep and a decreased sympathovagal cardiac balance (Kahn et al, 2003).…”

Section: Congenital Disorders Related To Abnormalities In Cardiac Innmentioning

confidence: 99%

Autonomic innervation of the developing heart: Origins and function

2008

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Maintenance of homeostatic circulation in mammals and birds is reliant upon autonomic innervation of the heart. Neural branches of mixed cellular origin and function innervate the heart at the arterial and venous poles as it matures, eventually coupling autonomic output to the cardiac components, including the conduction system. The development of neural identity is controlled by specific networks of genes and growth factors, whereas functional properties are governed by the use of different neurotransmitters. In this review, we summarize briefly the anatomic arrangement of the vertebrate autonomic nervous system and describe, in detail, the innervation of the heart. We discuss the timing of cardiac innervation in the chick and mouse, emphasizing the relationship of the cardiac neural networks to the anatomical structures within the heart. We also discuss the variable contribution of the neural crest to vagal cardiac nerves, and summarize the main neurotransmitters secreted by the developing sympathetic and parasympathetic autonomic divisions. We provide an overview of the main growth factor and gene families involved in neural development, discussing how these factors may impact upon the development of cardiac abnormalities in congenital syndromes associated with autonomic dysfunction.

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Sudden infant deaths: stress, arousal and SIDS

Cited by 27 publications

References 57 publications

Infant sleep position, head shape concerns, and sleep positioning devices

Infant sleep position, head shape concerns, and sleep positioning devices

Thermoregulatory Control of Feeding and Sleep in Premature Infants

Autonomic innervation of the developing heart: Origins and function

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