Sudden Loss of Consciousness, Dyspnea, and Hypoxemia in a Previously Healthy Young Man

Fred, Herbert L.; Yang, Mary Y

doi:10.1161/01.cir.91.12.3017

Cited by 20 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the existing literature, most studies have focused on the association between respiratory diseases and seizures; no retrospective or prospective studies have assessed a large number of patients. Patients with pulmonary embolism who present with symptomatic seizures account for fewer than 1% of all patients with symptomatic seizures, and cases of pulmonary hypertension with symptomatic seizures are rare 7,14,15 . Fred was the first author to describe a case of pulmonary embolism that presented with generalized tonic-clonic seizures following an abrupt-onset syncope 7 .…”

Section: Discussionmentioning

confidence: 99%

“…For example, symptomatic seizures can manifest due to the effects of various acute medical or toxic conditions in the CNS, and the resulting organic brain damage and neurological dysfunction can cause recurrent seizures 3,4 . The most common systemic diseases involved in the etiology of seizures include a wide range of cardiopulmonary diseases, such as long QT syndrome, bradycardia, rhythm disturbances (e.g., asystole), systemic hypertension (HT), pulmonary embolism, and pulmonary hypertension, and disturbances in cerebral perfusion have also been implicated in the pathophysiology of seizures [5][6][7][8] . Similar to the presence of systemic comorbidities, the presence of seizures may considerably affect the course of a respiratory disease, treatment for this disease, and length of hospital stay.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Seizures in patients with respiratory disease - a retrospective single center study

Aydın

Özdemir

Gündüz

et al. 2020

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective: Seizures are a neurological condition commonly experienced during the follow-up period after systemic or metabolic disorders. The aim of the present study was to determine the etiological factors of seizures in patients at a tertiary care chest clinic. Methods: We reviewed all neurology consultations that were requested due to seizures in inpatient clinics in a tertiary care hospital specializing in respiratory disorders between January 2011 and January 2018 were retrospectively reviewed. Results: The present study included 705 of 2793 (25.2%) patients who requested consultations for seizures during the study period. The mean age of the sample was 64.05±17.19 years. Of the 705 patients, 307 (43.5%) had a previous history of epilepsy (Group I) and 398 (56.5%) had a first-time seizure and were considered to have symptomatic seizures (Group II). Multiple factors played roles in the development of seizures in 54.8% of the patients. In most patients, metabolic causes, systemic infections, and drug use were identified and an intracranial metastatic mass lesion was the major cause in patients with lung cancer. Rates of hypoxemia and respiratory acidosis were significantly higher in patients with symptomatic seizures (Group II) than in patients with primary epilepsy (Group I). Conclusions: Blood gas changes such as hypoxemia and respiratory acidosis were among the factors statistically associated with the development of symptomatic seizures in patients with respiratory diseases. Additionally, hypoxemia, hypercapnia, and respiratory acidosis were correlated with mortality in patients hospitalized for respiratory system diseases who requested consultations for seizures.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Seizures in patients with respiratory disease - a retrospective single center study

Aydın

Özdemir

Gündüz

et al. 2020

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Seizures are reported in the literature as a presenting symptom of various cardiopulmonary pathologies such as long QT syndrome [ 2 ], severe bradycardia [ 3 ], systemic hypertension [ 4 ], and pulmonary embolism [ 5 ]. Acute PE presenting with new onset seizure occurs in less than 1 percent of cases [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The majority of literature discussing PE presenting as seizures is found in case reports. Review of previous case reports including Fred and Yang in 1995 [ 5 ], Marine and Goldhaber in 1997 [ 6 ], Meyer in 2009 [ 7 ], Shah and Darwent in 2009 [ 8 ], Volz and Jasani in 2014 [ 9 ], and Ching et al in 2015 [ 10 ] revealed 37.5% (3 out of 8) of the cases did not survive the hospital encounter, which is consistent with both massive PE mortality rates of 25–65% [ 11 ] and untreated PE mortality rate of 30% [ 1 ]. The mortality rate for submassive and low risk PE is 3% and 1%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Seizure and Pulmonary Embolism: A Differential That Can Save a Life

Pourshahid

Dedhia

Hakim

et al. 2017

Case Reports in Pulmonology

View full text Add to dashboard Cite

Seizures is a relatively common presentation with a wide differential diagnosis. However, seizures presenting secondary to underlying pulmonary emboli are rare and, without prompt recognition and management, this easily treatable condition can be potentially fatal. The few available case reports discussing seizures and PE reveal a high mortality rate which underscores the importance of prompt diagnosis. A 38-year-old woman presented to the emergency room having experienced loss of consciousness and a generalized tonic-clonic seizure at home. In the emergency room, her presenting signs and symptoms included tachycardia, worsening dyspnea, mild hypoxemia, and elevated D-dimer. Pertinent history findings revealed she recently received depot hormonal contraceptive treatments. Her initial workup included an EKG which showed sinus tachycardia without evidence of right heart strain. Subsequently a chest CT with angiography revealed massive bilateral pulmonary emboli. DVT studies also revealed a unilateral acute DVT. The patient was promptly started on therapeutic anticoagulation and stabilized. Fortunately, the patient remained symptom-free and eventually was discharged with close follow-up. The goal of this report is to make clinicians more aware of the possibility that seizures, along with the appropriate clinical findings, can be caused by acute PE.

show abstract

“…More recently, Fred and Yang3 described the case of a previously healthy 37-year-old man who presented with two syncopal episodes, the first associated with incontinence of urine and tonic bilateral upgaze and the second with tonic-clonic activity of both arms. He eventually died 6 h after initial presentation and, at post-mortem examination, a large pulmonary saddle embolus was discovered.…”

Section: Discussionmentioning

confidence: 99%

Acute pulmonary embolism presenting as seizures

Shah

Darwent

2009

Emergency Medicine Journal

View full text Add to dashboard Cite

Pulmonary embolism (PE) is a common and potentially fatal condition. The case is presented of a young woman who presented to the emergency department with first-time seizures. On further investigation and corroborated by post-mortem findings, this was found to be a manifestation of PE. The purpose of this report is to highlight to the clinical community that PE can present in a varied fashion and that, because of this, its diagnosis can occasionally be delayed. Vigilance is advised and expert clinical acumen is needed in young non-smoking persons with previously normal respiratory physiology who present with signs and symptoms of respiratory compromise, irrespective of the predominant or masking presentation.

show abstract

Sudden Loss of Consciousness, Dyspnea, and Hypoxemia in a Previously Healthy Young Man

Cited by 20 publications

References 23 publications

Seizures in patients with respiratory disease - a retrospective single center study

Seizures in patients with respiratory disease - a retrospective single center study

Seizure and Pulmonary Embolism: A Differential That Can Save a Life

Acute pulmonary embolism presenting as seizures

Contact Info

Product

Resources

About