Sudden Sensorineural Hearing Loss in Children: Clinical Characteristics, Etiology, Treatment Outcomes, and Prognostic Factors

Lu, Yuqing; Zhou, Liangqiang; Imrit, Tejvansh Shenoy; Liu, Aiguo

doi:10.1097/mao.0000000000002190

Cited by 28 publications

(17 citation statements)

References 19 publications

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“…Postulated causes of idiopathic SSNHL include viral cochleitis, cochlear membrane disruption, microvascular occlusion, autoimmune disorders [32]. Another rarely mentioned postulated cause of idiopathic SSNHL might be acute URIs contributing to inflammation-related cochleitis, a hypercoagulable state, and autoimmune disorders [32][33][34]. To investigate the association between acute URIs and SSNHL, we conducted a case-crossover study to estimate the risk of acute URIs for SSNHL.…”

Section: Discussionmentioning

confidence: 99%

Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study

Lin

Kuo

2021

IJERPH

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The etiology of sudden sensorineural hearing loss (SSNHL) has been unclear until now. Understanding its potential etiology is crucial for the development of preventive medicine. In this study, we investigated the association between acute upper respiratory tract infections (URIs) and SSNHL risk. We conducted a case-crossover study by using the longitudinal health insurance database derived from the National Health Insurance Research Database in Taiwan. Individual acute URI between the case and control periods was reviewed. Multivariable conditional logistic regression models were used to estimate the adjusted odds ratios (aORs) of SSNHL risk associated with acute URIs after adjustments for potential confounders. In total, 1131 patients with SSNHL between 2010 and 2013 fulfilled our inclusion criteria and were included. The aOR (95% confidence interval [CI]) for SSNHL was 1.57 (1.20–2.05) in relation to acute URIs one month before the index date. Moreover, the aORs (95% CIs) of the female and young to middle-aged (≤65 years) populations were 1.63 (1.13–2.36) and 1.76 (1.29–2.40), respectively. In addition, the association between SSNHL and acute URIs was decreased over time. The aOR for SSNHL was 1.25 (1.01–1.56) in relation to acute URIs three months before the index date. A cute URIs increase SSNHL risk and are a potential risk factor for SSNHL. The establishment of a feasible health policy for the prevention of acute URIs is crucial for SSNHL prevention, particularly in female, and young to middle-aged populations.

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Section: Discussionmentioning

confidence: 99%

Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study

Lin

Kuo

2021

IJERPH

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“…SSNHL is found in all age groups that most commonly between the ages of 30-60, but fewer cases have been reported in children and the elderly (3). Alexander and Harris reported the incidence as 11/100000 in children under 18 years of age and 27/100000 in patients over 65 years of age (4). Most of the cases are unilateral; less than 2% of patients have bilateral hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“…The degree of hearing loss can range from mild to total hearing loss. Tinnitus, vertigo, and dizziness may accompany hearing loss (4).…”

Section: Introductionmentioning

confidence: 99%

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The Role of Hyperbaric Oxygen Therapy in Sudden Sensorineural Hearing Loss in Children

ÖZER¹,

Aysel²

2022

Turkish Journal of Pediatric Disease

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Objective: Sudden Sensorineural Hearing Loss (SSNHL) is an otological emergency. Permanent SSNHL can seriously affect the social life, psychology, and language development of pediatric patients. There is no consensus the treatment of SSNHL. We compared the etiology, prognostic factors, and treatment results in pediatric patients who received hyperbaric oxygen therapy (HBOT) in addition to systemic steroid therapy with a diagnosis of SSNHL. Material and Methods:The files of 15 children were received HBOT with the diagnosis of SSNHL, between the ages of 8-18 years, and followed-up at least three months were retrospectively analyzed. Results:The ages of patients with SSNHL ranged from 8 to 18 years of age (mean 14.47±3.31 years). Seven (46.7%) patients had complete recovery, and two (13.3%) patients had partial recovery, two (13.3%) patients had slight recovery, four (26.7%) patients had no improvement. While pre-treatment PTAs of the patients were ranged between 28 to 109 dB HL (mean±sd; 57.3±26.2 dB HL), post-treatment PTAs were 6 to 88 dB HL (38±27.3 dB HL), (p=0.002). No significant difference was found between age, gender, number of HBOT sessions and response to treatment (p = 0.581, p = 0.904, p = 0.357, p = 0.184, respectively). Conclusion:Hyperbaric oxygen therapy is a safe and well-tolerated treatment modality for pediatric SSNHL patients. To avoid ethical and legal problems, we think that pediatric patients with a diagnosis of SSNHL should be initiated with the consent of the patient's parents.

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“…Recent studies of pSSNHL have focused on clinical characteristics, treatment, outcomes, and prognostic factors (3,8,18,19). Imaging findings are either only briefly discussed (8,18,19), or entirely omitted (3).…”

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confidence: 99%

Radiologic Findings in Pediatric Sudden Sensorineural Hearing Loss

Tey

Kadom

Dedhia

2021

Otology &Amp; Neurotology

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Objective: Pediatric sudden sensorineural hearing loss (pSSNHL) is a rare phenomenon. There is currently no consensus on the role of imaging in the work-up for this patient population. We aim to evaluate the efficacy of magnetic resonance imaging (MRI) and high-resolution computed tomography (CT) studies in determining the etiology of pSSNHL. Study Design: Retrospective case review. Setting: Tertiary Hospital and Ambulatory Otolaryngology Clinic. Patients: Patients 18 years of age with sudden sensorineural hearing loss (SSNHL) and who had either MRI or CT imaging between January 2010 and May 2019 were included. Intervention: Diagnostic imaging. Main Outcome Measures: Clinical characteristics and radiology impressions.Results: A total of 11 patients were identified, and 10 had unilateral SSNHL. MRI was performed on all patients, five patients had additional CT imaging. Abnormal imaging findings relevant to SSNHL were observed in five patients (45.5%), which included enlarged endolymphatic duct and sac, labyrinthine ossification, apical petrositis, hypoplastic cochlear nerve, and arachnoid cyst in the internal auditory canal; one patient had unrelated findings (enlarged pituitary gland), all remaining imaging studies were normal. Conclusion: In our cohort, we found a higher imaging yield on pSSNHL than what has been reported for adult populations, indicating that the use of imaging in the diagnostic work-up is especially important in children.

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Sudden Sensorineural Hearing Loss in Children: Clinical Characteristics, Etiology, Treatment Outcomes, and Prognostic Factors

Cited by 28 publications

References 19 publications

Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study

Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study

The Role of Hyperbaric Oxygen Therapy in Sudden Sensorineural Hearing Loss in Children

Radiologic Findings in Pediatric Sudden Sensorineural Hearing Loss

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