Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Rossini, Bruno Almeida Antunes; Penido, Norma de Oliveira; Munhoz, Mário Sérgio Lei; Bogaz, Eduardo Amaro; Curi, Renata Souza

doi:10.1055/s-0036-1586162

Cited by 58 publications

(71 citation statements)

References 52 publications

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“…The most important audiological test battery in all cases should include PTA possibly extended to the high-frequency region, TEOAE and DPOAE, and ABR [5, 129]. Vestibular testing should include a basic vestibular exam integrated with caloric test, video head impulse test, and VEMPs [129].…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

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Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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“…The pathophysiologic causes of SSNHL have not yet been fully explained. Several etiologies associated with immunologic, ischemic, and endocrine factors have been proposed [12][13][14] . In addition to associations with chronic diseases such as hypertension, hypercholesteremia, and diabetes, recent studies have demonstrated a relation between SSNHL and depression 15,16 .…”

mentioning

confidence: 99%

Bidirectional relation between depression and sudden sensorineural hearing loss: Two longitudinal follow-up studies using a national sample cohort

Kim

Min

Lee

et al. 2020

Sci Rep

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A few studies have explored the association between depression and sudden sensorineural hearing loss (SSnHL). this study was aimed to investigate the reciprocal relations between SSnHL and depression using a nationwide cohort of the Korean population. Subjects aged > 20 years from the Korean National Health Insurance Service-National Sample Cohort were enrolled from 2002 to 2013. In study I, a total of 60,178 depressed patients were matched 1:4 with 242,872 control I subjects. In study II, a total of 4,328 SSNHL patients were 1:4 matched with 17,312 control II subjects. They were matched for age, sex, income, and region of residence. the charlson comorbidity index (cci) was adjusted. Subgroup analysis was performed according to age and sex. the crude and adjusted cci hazard ratios (HRs) of SSnHL in depressed patients (study i) and depression in SSnHL patients (study ii) were analyzed using the stratified Cox proportional-hazard model. In study I, the depression group exhibited an elevated adjusted HR of SSNHL 1.16 times that of the control group (confidence interval [95% CI] = 1.02-1.31, p < 0.023). The middle-aged women subgroup demonstrated an increased risk of SSNHL within the depression group. In study II, the SSNHL group showed a higher adjusted HR of depression 1.29 times that of control II group (95% CI = 1.06-1.57, P = 0.010). The middle-aged women subgroup showed an elevated risk of depression in the SSnHL group. the risk of SSnHL was elevated in the depressed patients and the risk of depression was increased in the SSnHL patients.

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“…9,10 Many published studies have demonstrated that systemic autoimmune diseases are risk factors for onset of SSNHL, a recent population-based research showed that patients with immune-mediated disease had a 4.27-fold increased the risk of SSNHL than those in the control group. 11 Similarly, Lee et al 12 found that patients with RA had a higher risk of suffering SSNHL compared with those without RA. However, few research studies have evaluated the effect of comorbid systemic autoimmune diseases on the prognosis of SSNHL.…”

Section: Introductionmentioning

confidence: 97%

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

Xie

Ning

She³

et al. 2019

The Laryngoscope

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Objectives Recent reports have identified autoimmune systemic diseases as a significant risk factor for sudden sensorineural hearing loss (SSNHL). We investigated whether systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) were correlated with the hearing recovery of SSNHL. Study Design A retrospective study. Methods Records of 663 SSNHL patients between January 2008 and January 2019 were retrospectively reviewed, including demographic, comorbid diseases, and hearing recovery. Patients were divided into four groups (complete, partial, slight, and no recovery) according to Siegel's criteria and Chinese Medical Association of Otolaryngology (CMAO) criteria. Multinomial logistic regression was performed to evaluate the effects of onset of treatment, initial hearing threshold, audiogram pattern, diabetes mellitus, SLE, and RA on the prognosis of SSNHL according to both criteria. Results Patients in complete recovery, partial recovery, slight recovery, and no improvement were 95 (14.3%), 183 (27.6%), 170 (25.6%), and 215 (32.4%) by Siegel's criteria, and 90 (13.6%), 152 (22.9%), 188 (28.4%), and 233 (35.1%) by CMAO criteria, respectively. Among the four groups, onset of treatment, initial hearing threshold, diabetes mellitus, SLE, RA, and profound audiogram pattern were found to be associated with recovery outcome by both Siegel's criteria and CMAO criteria (P < .05). According to analysis results, presence of SLE, RA, diabetes mellitus and higher initial hearing threshold were significantly correlated with a poor prognosis by both Siegel's criteria and CMAO criteria (P < .05). Conclusion Comorbid SLE or RA may negatively affect the prognosis of SSNHL. Lower initial hearing threshold and absence of diabetes mellitus are associated with favorable hearing recovery. Level of Evidence 4. Laryngoscope, 130:2475–2480, 2020

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Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Cited by 58 publications

References 52 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Bidirectional relation between depression and sudden sensorineural hearing loss: Two longitudinal follow-up studies using a national sample cohort

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

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