Sudden, unexpected and natural death in young adults of age between 18 and 35 years: A clinicopathological study

Chaturvedi, Madhu; Satoskar, Meera; Khare, Manisha; Kalgutkar, Alka

doi:10.4103/0377-4929.77323

Cited by 13 publications

(9 citation statements)

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“…This is in keeping with the study in India, which also showed a male preponderance, with SD mainly occurring in the age group of 30–35-year-olds 13. This could be because the males are the breadwinners and they could not afford to stay away from work despite ill health; hence, they kept working while ill.…”

Section: Discussionsupporting

confidence: 88%

Communicable disease-related sudden death in the 21st century in Nigeria

Akinwusi

Komolafe

Olayemi³

et al. 2013

IDR

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BackgroundSome cases of sudden death (SD) have been attributed to communicable diseases (CD) in middle- and low-income countries of the world even in this 21st century. CDs produce clinical symptoms and signs over several days before culminating in death. They are also amenable to treatment with antimicrobials if affected persons present early. We sought to find out the incidence of CD-related SD at the Ladoke Akintola University of Technology Teaching Hospital (Osogbo, Osun State, Nigeria) – a tertiary health facility in southwest Nigeria – and the prevailing associated factors.MethodsWe conducted a retrospective study of CD-related SD in adult patients aged 18 years and older that occurred from January 2003 to December 2011. The Statistical Package for the Social Sciences version 16 was used for analysis of the generated data. Percentages and frequencies were calculated.ResultsThere were 17 (39.6%) CD-related SDs out of the 48 cases of SD studied. CD-related SD also accounted for 2.4% of all adult medical admissions. The mean age of the patients was 37.6 ± 11.6 years, age range of 25–62 years, mode of 25 years, and median 34 years. The male-to-female ratio was 1.8:1. Typhoid sepsis was responsible for SD in 47.1% of patients, pulmonary tuberculosis in 17.7% of patients, and lobar pneumonia in 17.7% of patients. The most affected age group was the 20–29-year-old group (41.2%), while the unskilled occupational group was the most affected occupational group with 35.3% of them having SD. Most of the patients with acute bacterial infection died of multiple organ failure.ConclusionThere is an urgent need to step up public health strategies to curtail infections in this environment, encourage better use of the existing health facilities by the people, and the government should strive hard to make health a top priority.

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Section: Discussionsupporting

confidence: 88%

Communicable disease-related sudden death in the 21st century in Nigeria

Akinwusi

Komolafe

Olayemi³

et al. 2013

IDR

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“…A similar picture was observed in a study done in India where majority were towards the upper limit of the age group [15]. Majority of deaths due to ischaemic heart disease are coming under this age group.…”

Section: Discussionsupporting

confidence: 85%

Sudden unexpected deaths of young adults in a tertiary care hospital for a period of four years

Kitulwatte¹,

Edirisinghe²

2015

Medico-Legal J SL

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Introduction Sudden unexpected natural death of a young adult is rare, but has a disproportionate impact on the community. This always requires a systematic forensic autopsy. At the completion of the autopsy it is expected to have the answers for all unanswered questions. However it is a challenge to the forensic pathologist since there are many sudden deaths without significant morphological anomalies. Objective: The aim of the study was to identify the causes and characteristics of sudden death among the young adults (less than 40 years of age) Study Design: Retrospective descriptive study was done based on the reports of post mortems performed on young adults who had died suddenly and unexpectedly due to natural reasons during past 4 years. The information was gathered on a pro-forma to fulfill the objectives. The data was analyzed using SPSS statistical package version 18. Results: Out of 54 autopsies analyzed, 78 % were males. 39% of the victims were of the age group of 36 to 40 years. 33% of the victims were brought to hospital before death. In 76% of the cases, a cause of death could be identified after macroscopic autopsy examination and the percentage increased to 89% after microscopy. Microscopy revealed or confirmed the cause of death in 52% of the cases. 44% were victims of sudden cardiac death. Cause of death was unascertained at the end of all the investigations in 11% of the cases. Conclusion: Cause of death has a cardiac origin in majority of sudden unexpected deaths in young adults in the sample examined. Macroscopic autopsy examination could identify a cause of death in majority while abnormalities identified at microscopic examination accounted for death in nearly half of the sudden unnatural deaths in young adults.

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“…3,4 Only a small amount of studies have investigated stroke subtypes in sudden death (SD) in the young, with a reported burden ranging from 4% to 14% of all SDs. [5][6][7][8][9][10][11][12] However, the previous studies have been conducted on either selected patient populations, or studies only including autopsied patients.…”

Section: Introductionmentioning

confidence: 99%

Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark

Ågesen

Risgaard

Zachariasardóttir

et al. 2017

International Journal of Stroke

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Background Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000-2009 and 2007-2009 in persons aged 1-35 years and 36-49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3%) were sudden death by stroke. There was a male predominance (56%) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1-49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94% of cases, whereof subarachnoid hemorrhage was the cause of death in 63% of cases. Seventeen (33%) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6%). Conclusions Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.

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Sudden, unexpected and natural death in young adults of age between 18 and 35 years: A clinicopathological study

Abstract: SUND in young adults is preventable. A meticulous post-mortem examination with special attention to the conduction system of heart and detailed toxicological analysis can pinpoint the cause of death in SADS.

Cited by 13 publications

References 0 publications

Communicable disease-related sudden death in the 21st century in Nigeria

Communicable disease-related sudden death in the 21st century in Nigeria

Sudden unexpected deaths of young adults in a tertiary care hospital for a period of four years

Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark

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