Sudden unexpected death in infants of narcotic-dependent mothers

Rajegowda, Benamanahalli; Kandall, Stephen R.; Falciglia, Horacio S.

doi:10.1016/0378-3782(78)90026-9

Cited by 55 publications

(21 citation statements)

References 15 publications

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“…In utero exposure to opiates (primarily methadone and heroin) has been shown in retrospective studies to be associated with an increased risk of SIDS. 223,224 With the exception of 1 study that did not show increased risk, 225 population-based studies have generally shown an increased risk with in utero cocaine exposure. [226][227][228] However, these studies did not control for confounding factors.…”

Section: Avoid Alcohol and Illicit Drug Use During Pregnancy And Aftementioning

confidence: 99%

SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment

Moon¹

2011

Pediatrics

219

115

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Despite a major decrease in the incidence of sudden infant death syndrome (SIDS) since the American Academy of Pediatrics (AAP) released its recommendation in 1992 that infants be placed for sleep in a nonprone position, this decline has plateaued in recent years. Concurrently, other causes of sudden unexpected infant death occurring during sleep (sleep-related deaths), including suffocation, asphyxia, and entrapment, and ill-defined or unspecified causes of death have increased in incidence, particularly since the AAP published its last statement on SIDS in 2005. It has become increasingly important to address these other causes of sleep-related infant death. Many of the modifiable and nonmodifiable risk factors for SIDS and suffocation are strikingly similar. The AAP, therefore, is expanding its recommendations from being only SIDS-focused to focusing on a safe sleep environment that can reduce the risk of all sleep-related infant deaths including SIDS. The recommendations described in this report include supine positioning, use of a firm sleep surface, breastfeeding, room-sharing without bed-sharing, routine immunization, consideration of a pacifier, and avoidance of soft bedding, overheating, and exposure to tobacco smoke, alcohol, and illicit drugs. The rationale for these recommendations is discussed in detail in this technical report. The recommendations are published in the accompanying “Policy Statement—Sudden Infant Death Syndrome and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment,” which is included in this issue (www.pediatrics.org/cgi/doi/10.1542/peds.2011-2220).

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Section: Avoid Alcohol and Illicit Drug Use During Pregnancy And Aftementioning

confidence: 99%

SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment

Moon¹

2011

Pediatrics

219

115

View full text Add to dashboard Cite

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“…306 In utero exposure to opiates (primarily methadone and heroin) has been shown in retrospective studies to be associated with an increased risk of SIDS. 307,308 With the exception of 1 study that did not show an increased risk, 309 population-based studies have generally shown an increased risk with in utero cocaine exposure. 310 -312 However, these studies did not control for confounding factors.…”

Section: Avoid Alcohol and Illicit Drug Use During Pregnancy And Aftementioning

confidence: 99%

SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment

Moon¹

2016

Pediatrics

491

446

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Approximately 3500 infants die annually in the United States from sleep-related infant deaths, including sudden infant death syndrome (SIDS), ill-defined deaths, and accidental suffocation and strangulation in bed. After an initial decrease in the 1990s, the overall sleep-related infant death rate has not declined in more recent years. Many of the modifiable and nonmodifiable risk factors for SIDS and other sleep-related infant deaths are strikingly similar. The American Academy of Pediatrics recommends a safe sleep environment that can reduce the risk of all sleep-related infant deaths. Recommendations for a safe sleep environment include supine positioning, use of a firm sleep surface, room-sharing without bed-sharing, and avoidance of soft bedding and overheating. Additional recommendations for SIDS risk reduction include avoidance of exposure to smoke, alcohol, and illicit drugs; breastfeeding; routine immunization; and use of a pacifier. New evidence and rationale for recommendations are presented for skin-to-skin care for newborn infants, bedside and in-bed sleepers, sleeping on couches/armchairs and in sitting devices, and use of soft bedding after 4 months of age. In addition, expanded recommendations for infant sleep location are included. The recommendations and strength of evidence for each recommendation are published in the accompanying policy statement, “SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment,” which is included in this issue.

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“…In newborns born to mothers on methadone, the QTc has been shown to be prolonged . There is also concern that infants born to mothers treated with opiates during pregnancy are at increased risk of sudden infant death syndrome, although the data are conflicting . Our study is the first to report the possible effect of a mu‐agonist on fetal QTc.…”

Section: Discussionmentioning

confidence: 82%

Magnetocardiographic identification of prolonged fetal corrected QT interval in women receiving treatment for opioid use disorder

Bolin

Escalona‐Vargas

Daily

et al. 2019

J of Obstet and Gynaecol

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Aim Pregnant women undergoing treatment for opioid use disorder (OUD) may be exposed to multiple QT prolonging agents. We used magnetocardiography to measure fetal QT intervals in mothers with OUD on buprenorphine therapy. Methods Fetal and maternal magnetocardiography was performed in pregnant women receiving buprenorphine‐assisted treatment (Disorder group); these were matched by gestational age to pregnant women who were opiate naïve (Reference group). Corrected QT intervals were determined using Bazett's formula and compared between groups. Results A total of eight women in the Disorder group matched to eight in the Reference group. Seven of the mothers (88%) in the Disorder group were smokers; there were no smokers in the Reference group. The average fetal corrected QT was significantly longer (P = 0.022) in the Disorder group than that in the Reference group (505 milliseconds [ms] ± 68.6 [standard deviation] vs 383 ms ± 70.3 [standard deviation]). Conclusion Novel data from this small sample demonstrate prolongation of fetal corrected QT in women with OUD participating in buprenorphine assisted therapy. Additional investigation from a larger sample is needed to clarify if fetal buprenorphine and/or tobacco exposure is associated with changes in fetal QT which would warrant further prenatal and postnatal testing.

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Sudden unexpected death in infants of narcotic-dependent mothers

Cited by 55 publications

References 15 publications

SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment

SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment

SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment

Magnetocardiographic identification of prolonged fetal corrected QT interval in women receiving treatment for opioid use disorder

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