Sudden, unexpected deaths due to primary intracranial neoplasms

DiMaio, S.; DiMaio, Vincent J.M.; Kirkpatrick, Joel B.; Eckert, William G.; Noguchi, Thomas T.

doi:10.1097/00000433-198003000-00007

Cited by 114 publications

(74 citation statements)

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“…Malignancies could also be found incidentally in medico-legal autopsies (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). In the present study such kind of malignancies was found 2.1 % in 3722 medicolegal autopsy cases in which histopathological examination was performed.…”

Section: Discussionsupporting

confidence: 59%

The Role of Forensic Autopsies in Diagnosis of Cancer

Çengel¹,

Uyanıker²,

Göçeoğlu³

et al. 2014

Bull Leg Med

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Death from cancer is mostly considered as natural deaths. The role of cancer as a cause of death in forensic autopsies such as sudden deaths, negligence or malpractice claims is being investigated. In a small amount of forensic cases, cancer is found incidentally at the autopsy. The aim of this study was to reveal characteristics of the cases in which cancer was diagnosed and malignancies' types in medico legal autopsies. The role of forensic autopsies in determining oncological diseases was discussed.Forensic autopsies were performed in the Morgue Department of Forensic Medicine Council in Izmir for eight years were retrospectively reviewed. Postmortem histopathological examination performed and malignant tumors diagnosed were included. Data about age, sex, location of tumors, immediate causes of death and the potential relation between tumors and the primary cause of death were investigated.In eight-year period (between 2001 and 2009), 3722 medicolegal autopsies were performed by postmortem histopathological examination. 79 cases with malignant tumors included in the study, 79.7% were male and 20.3% were female, mean age was 54.96±20.35 (range: 7-88) years. The tumors were most frequently located in respiratory system (35.4%), gastrointestinal system (19%), genitourinary system (10.1%) and central nervous s y s t e m ( 8 . 9 % ) r e s p e c t i v e l y. A c c o r d i n g t o histopathological classification, the most frequent tumors were epithelial tumors (65.8%), followed by hemopoetic KANSER TANISINDA ADLİ OTOPSİLERİN ROLÜ ÖZETKanser, çoğunlukla doğal orijinli bir ölüm nedeni olarak karşımıza çıkmaktadır. Bununla birlikte kanser olguları; ani beklenmedik ölüm, ihmal veya malpraktis iddialarında adli nitelik kazanmakta ya da adli otopsilerde rastlantısal bir bulgu olarak karşımıza çıkmaktadır. Medikolegal otopsilerde, onkolojik hastalıkların yerinin, ölüm nedenleri veya ölüme neden olabilecek diğer faktörler yönünden incelendiği az sayıda çalışmaya ulaşılmıştır. Bu çalışmada; bölgemizde yapılan adli otopsiler arasında malignite tanısı almış olguların özelliklerinin ve malignite türlerinin ortaya konulması amaçlandı. Ayrıca, onkolojik hastalıkların, ölüm nedeni ve ölümde rol alan/kolaylaştıran etmen olarak rolünü ortaya koymada adli otopsinin yeri ve önemi değerlendirilmeye çalışıldı.

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Section: Discussionsupporting

confidence: 59%

The Role of Forensic Autopsies in Diagnosis of Cancer

Çengel¹,

Uyanıker²,

Göçeoğlu³

et al. 2014

Bull Leg Med

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“…In our experience, it is a rare cause of sudden death, only one case being identified in the files of the department of forensic medicine from 1995 to 1998. In the literature, of the primary brain tumours glioblastoma multiforme predominates 47 ; other tumours that have been reported to present in this way include oligodendroglioma, medulloblastoma, lymphoma, teratoma, and pituitary adenoma (as a result of apoplexy). Of the metastatic intracranial tumours bronchial carcinoma, choriocarcinoma, and melanoma are the most common.…”

Section: Sudden Death Caused By Brain Tumoursmentioning

confidence: 99%

Sudden unexplained death in adults caused by intracranial pathology

Black¹,

Graham²

2002

Journal of Clinical Pathology

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“…Frequency of sudden, unexpected death due to a primary CNS mass is in the range of 0.11% to 0.24% in forensic autopsy series. [8][9][10][11][12][13][14] Symptoms and death occur in patients with intracranial mass since it increases ICP and leads to cerebral herniation. A small CNS mass placed in pathophysiological critical points blocks cerebrospinal fluid (CSF) or even if it does not block CSF, it may increase ICP and lead to herniation.…”

Section: Discussionmentioning

confidence: 99%

“…A small CNS mass placed in pathophysiological critical points blocks cerebrospinal fluid (CSF) or even if it does not block CSF, it may increase ICP and lead to herniation. 4,10,11,14 Epileptic seizures caused by CNS tumors are also considered to be a cause of sudden death. 11,12 Especially infra-tentorial tumors can affect cardiac and respiratory centers, and lead to sudden death.…”

Section: Discussionmentioning

confidence: 99%

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Sudden Unexpected Death in a Child with Vomiting and Diarrhea due to Intracranial Mass Lesion

Akkoyun¹,

Derinöz²

2017

cayd

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Nausea and vomiting are common sequelae of a multitude of disorders that can range from mild to severe conditions. Intracranial mass lesions can occasionally present with vomiting followed by acute neurological deterioration and sudden death, although they are usually accompanied by ongoing neurological symptoms. We aimed to report an unusual presentation of an intracranial mass resulting in death to increase awareness among pediatric emergency physicians. A previously healthy 15-month-old boy presented to the pediatric emergency department (PED) with nausea, vomiting and diarrhea. He did not have any symptom of a neurological disorder. He acutely deteriorated, developed cardiopulmonary arrest and was intubated. His cranial computed tomography showed dilatation of the third and the lateral ventricles caused by a 3x4x2 cm tumor in the posterior fossa with an evidence of hemorrhage in the tumor with minimal tonsillar herniation. An emergent extra-ventricular drainage was performed to relieve elevated intracranial pressure. He did not show any improvement and died 9 hours after admission. Common symptoms in PED like nausea and vomiting are mostly due to benign etiologies such as gastroenteritis. One should always keep in mind that there may be an underlying intracranial pathology and further investigation should not be delayed. Keywords: Child, sudden death, intracranial mass Bulantı ve kusma hafiften şiddetli durumlara kadar değişebilen çok sayıda hastalığın ortak semptomudur. İntrakraniyal kitle lezyonları bazen kusma ve bunu takiben akut nörolojik bozulma ve ani ölümle birlikte ortaya çıkabilir. Buna genellikle devam eden nörolojik bulgular eşlik eder. Bu çalışmada çocuk acil hekimleri arasında bilinç düzeyini artırmak için ölümle sonuçlanan intrakraniyal bir kitlenin alışılmadık bir sunumunu rapor etmeyi amaçladık. Daha önce sağlıklı olan 15 aylık bir erkek çocuk, çocuk acil servisine (ÇAS) bulantı, kusma ve ishal ile başvurdu. Herhangi bir nörolojik semptomu yoktu. Genel durumu aniden bozulan, kardiyopulmoner arrest geliştiren hasta entübe edildi. Beyin bilgisayarlı tomografisinde lateral ve üçüncü ventrikülde genişlemeye yol açan, posterior fossa'da 3x4x2 cm tümor saptandı. Tümör içinde minimal tonsiller herniasyona yol açan hemorajik alan görüldü. Artmış intrakraniyal basıncı azaltmak için acil ekstra ventriküler drenaj yapıldı. Gerekli tüm müdahalelere rağmen hasta 9 saat içinde kaybedildi. ÇAS'de bulantı ve kusma gibi sık görülen semptomlar, çoğunlukla gastroenterit gibi benign etiyolojilerden kaynaklanmaktadır. Bu tip hastalarda altta yatan intrakraniyal bir patolojinin olabileceği ve daha fazla araştırmanın geciktirilmemesi gerektiği akılda tutmalıdır. Anahtar Kelimeler: Çocuk, ani ölüm, intrakraniyal kitle AbstractÖz

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Sudden, unexpected deaths due to primary intracranial neoplasms

Cited by 114 publications

References 0 publications

The Role of Forensic Autopsies in Diagnosis of Cancer

The Role of Forensic Autopsies in Diagnosis of Cancer

Sudden unexplained death in adults caused by intracranial pathology

Sudden Unexpected Death in a Child with Vomiting and Diarrhea due to Intracranial Mass Lesion

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