Sudden unexplained death among persons 1–35 years old

Postmortem Molecular Screening for Cardiac Ryanodine Receptor Type 2 Mutations in Sudden Unexplained Death R420W Mutated Case With Characteristics of Status Thymico-Lymphaticus

“…1 Fatal arrhythmia has been suggested as being involved in the etiology of SUD. [2][3][4] Recent progress in postmortem molecular analysis has revealed that mutations of the cardiac ryanodine receptor type 2 (RyR2) gene are involved in some cases of SUD.…”

Modern Approach to the Sudden Unexpected Death Investigation

“…Previous data suggest that 10% to 30% of sudden death in the young is autopsy-negative. [2][3][4] But, Mellor et al 1 report that 45% of the cases they studied had a normal autopsy, including 10 infants <1 year. The authors chose to remove this subset from the study cohort because of the likelihood that their deaths were from sudden infant death syndrome, but acknowledged that 10% to 15% of deaths from sudden infant death syndrome are likely because of channelopathies.…”

Preventing sudden cardiac death in the young: Is electrocardiogram screening the most effective means?

“…The prevalence of a negative autopsy leading to no diagnosis is also quite variable and is less common when investigations on extended family members are performed after a negative autopsy on the index case (9). Cardiac diagnoses are made at autopsy less frequently in the one-to 14-year-old age group compared with the 15-to 19-year-old group; however, there are more unexplained (ie, negative autopsy) cases in the younger group (10).…”