Sudden unexplained death in schizophrenia patients: An autopsy-based comparative study from China

Wang, Shouyu; He, Meng; Andersen, John; Lin, Yezhe; Zhang, Molin; Liu, Zheng; Li, Liliang

doi:10.1016/j.ajp.2022.103314

Cited by 3 publications

(1 citation statement)

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“…Two cases remained unexplained after systemic autopsy and toxicological examinations. In an autopsy study, Wang et al ( 10 ) revealed that insufficient antipsychotic treatment for patients with schizophrenia could lead to higher rate of sudden unexplained death in a Han Chinese population in Mainland China. Li X. et al juxtaposed the relationship between personality characteristics and craniocerebral trauma from a traffic accident patient population in Shanghai, China.…”

Section: Forensic Studies Discover More Dimensions In the Comorbidity...mentioning

confidence: 99%

Editorial: Comorbidity in patients with psychiatric disorders: Epidemiological and molecular perspectives

Lin

Guan

et al. 2023

Front. Psychiatry

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Section: Forensic Studies Discover More Dimensions In the Comorbidity...mentioning

confidence: 99%

Editorial: Comorbidity in patients with psychiatric disorders: Epidemiological and molecular perspectives

Lin

Guan

et al. 2023

Front. Psychiatry

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Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death

Song,

Bian,

Lin

et al. 2024

Forensic Science International

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Heart abnormality associates with a wide spectrum of psychiatric disorders: Evidence from Mendelian randomization analyses

Chen,

Song,

Chen

et al. 2024

World J Psychiatry

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Psychiatric disorders and heart abnormality are closely interconnected. Previous knowledge has been well-established that psychiatric disorders can lead to increased cardiovascular morbidity and even sudden cardiac death. Conversely, whether heart abnormality contributes to psychiatric disorders remains rarely studied. The work by Zhang et al pointed out that chronic heart failure had effects on the anxiety and depression (AD) severity, and indices including left ventricular ejection fraction, N-terminal pro-brain natriuretic peptide and interleukin-6 were independent risk factors for AD severity. In addition to the aforementioned AD, we herein find that heart failure might additionally impact the development of autism spectrum disorder and post-traumatic stress disorder (albeit P > 0.05), and significantly protects against the presence of attention deficit hyperactivity disorder (ADHD), [odds ratio (OR) = 0.61, P = 0.0071] by using a Mendelian randomization analysis. Bradycardia is also a protective factor for ADHD (OR = 0.61, P = 0.0095), whereas hypertrophic cardiomyopathy is a mild risk factor for schizophrenia (OR = 1.02, P = 0.032). These data suggest a wide spectrum of psychiatric disorders secondary to heart abnormality, and we highlight more psychiatric care that should be paid to patients with heart abnormality.

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Sudden unexplained death in schizophrenia patients: An autopsy-based comparative study from China

Cited by 3 publications

References 35 publications

Editorial: Comorbidity in patients with psychiatric disorders: Epidemiological and molecular perspectives

Editorial: Comorbidity in patients with psychiatric disorders: Epidemiological and molecular perspectives

Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death

Heart abnormality associates with a wide spectrum of psychiatric disorders: Evidence from Mendelian randomization analyses

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