Sudomotor dysfunction in people with neuromyelitis optica spectrum disorders

Habek, Mario; Andabaka, Marko; Fanciulli, Alessandra; Jakob, Gregor Brecl; Drulović, Jelena; Leys, Fabian; Pauli, Franziska Di; Hegen, Harald; Auer, Michael; Pekmezović, Tatjana; Mesaroš, Šarlota; Jovicevic, Vanja; Junaković, Anamari; Wenning, Gregor K.; Deisenhammer, Florian; Gabelić, Tereza; Barun, Barbara; Adamec, Ivan; Skorić, Magdalena Krbot

doi:10.1111/ene.15413

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…In recent years, research on autonomic dysfunction in NMOSD patients has been obtained. Two studies compared autonomic dysfunction between patients with NMOSD and those with MS [ 12 , 13 ], finding a significant proportion of NMOSD patients suffered autonomic dysfunction and were more often symptomatic than MS patients in certain domains of dysautonomia. Another study suggested 74.1% of patients with NMOSD suffered dysautonomic symptoms and investigated the correlated clinical and MRI factors of dysautonomia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Yang

Xie

et al. 2023

BMC Neurol

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Background This study aimed to investigate the clinical risk factors of dysautonomic symptom burden in neuromyelitis optica spectrum disorder (NMOSD) and its impact on patients’ quality of life. Methods A total of 63 NMOSD patients and healthy controls were enrolled. All participants completed the Composite Autonomic Symptom Score 31 (COMPASS-31) to screen for symptoms of autonomic dysfunction. A comprehensive clinical evaluation was performed on NMOSD patients, such as disease characteristics and composite evaluations of life status, including quality of life, anxiety/depression, sleep, and fatigue. Correlated factors of dysautonomic symptoms and quality of life were analyzed. Results The score of COMPASS-31 in the NMOSD group was 17.2 ± 10.3, significantly higher than that in healthy controls (P = 0.002). In NMOSD patients, the higher COMPASS-31 score was correlated with more attacks (r = 0.49, P < 0.001), longer disease duration (r = 0.52, P < 0.001), severer disability (r = 0.50, P < 0.001), more thoracic cord lesions (r = 0.29, P = 0.02), more total spinal cord lesions (r = 0.35, P = 0.005), severer anxiety (r = 0.55, P < 0.001), severer depression (r = 0.48, P < 0.001), severer sleep disturbances (r = 0.59, P < 0.001), and severer fatigue (r = 0.56, P < 0.001). The disability, total spinal cord lesions, and fatigue were revealed to be independently associated factors. Further analysis revealed that the COMPASS-31 score was independently correlated with scores of all the domains of patients’ quality of life scale (P < 0.05). Conclusions Dysautonomic symptom burden is correlated with decreased quality of life and certain clinical characteristics such as disability, the burden of spinal cord lesions, and fatigue in NMOSD patients. Investigation and proper management of autonomic dysfunction may help to improve the quality of life in patients with NMOSD.

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Section: Introductionmentioning

confidence: 99%

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Yang

Xie

et al. 2023

BMC Neurol

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show abstract

“…In recent years, research on autonomic dysfunction in NMOSD patients has been obtained. Two studies compared autonomic dysfunction between patients with NMOSD and those with MS (12,13), nding a signi cant proportion of NMOSD patients suffered autonomic dysfunction and were more often symptomatic than MS patients in certain domains of dysautonomia. Another study suggested 74.1% of patients with NMOSD suffered dysautonomic symptoms and investigated the correlated clinical and MRI factors of dysautonomia (14).…”

Section: Introductionmentioning

confidence: 99%

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Yang

Xie

et al. 2022

Preprint

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Background The aim of this study was to investigate the clinical risk factors of dysautonomic symptom burden in neuromyelitis optica spectrum disorder (NMOSD), and its impact on patients’ quality of life. Methods A total of 63 NMOSD patients and healthy controls were enrolled. All participants completed the Composite Autonomic Symptom Score 31 (COMPASS-31) to screen for symptoms of autonomic dysfunction. A comprehensive clinical evaluation was performed in NMOSD patients, including disease characteristics and composite evaluations of life status, including quality of life, anxiety/depression, sleep, and fatigue. Correlated factors of dysautonomic symptoms and quality of life were analyzed. Results The score of COMPASS-31 in the NMOSD group was 17.2 ± 10.3, significantly higher than that in healthy controls (P = 0.002). In NMOSD patients, the higher COMPASS-31 score was correlated with more attacks (r = 0.49, P < 0.001), longer disease duration (r = 0.52, P < 0.001), severer disability (r = 0.50, P < 0.001), more thoracic cord lesions (r = 0.29, P = 0.02), more total spinal cord lesions (r = 0.35, P = 0.005), severer anxiety (r = 0.55, P < 0.001), severer depression (r = 0.48, P < 0.001), severer sleep disturbances (r = 0.59, P < 0.001), and severer fatigue (r = 0.56, P < 0.001). The disability, total spinal cord lesions and fatigue were revealed to be independently associated factors. Further analysis revealed that the COMPASS-31 score was the independently correlated with score of all the domains of patients’ quality of life scale (P < 0.05). Conclusions Dysautonomic symptom burden is correlated with decreased quality of life and certain clinical characteristics such as disability, spinal cord lesions and fatigue in NMOSD patients. Investigation and proper management of autonomic dysfunction may help to improve the quality of life in patients with NMOSD.

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Impact of the autonomic dysfunction on the quality of life in people with NMOSD and MS: An international cross-sectional study

Andabaka,

Pekmezovic,

Crnosija

et al. 2023

Multiple Sclerosis and Related Disorders

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Sudomotor dysfunction in people with neuromyelitis optica spectrum disorders

Cited by 3 publications

References 27 publications

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Impact of the autonomic dysfunction on the quality of life in people with NMOSD and MS: An international cross-sectional study

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