Sudoriferous acrosyringeal acantholytic disease

Hashimoto, Ken; Moiin, Ali; Chang, Mary Wu; Tada, Jôji

doi:10.1111/j.1600-0560.1996.tb01289.x

Cited by 23 publications

(21 citation statements)

References 29 publications

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“…Although many have investigated the sweat gland in GD, little definite pathologic connection has been demonstrated. 30,31 We found no pathologic condition of the sweat glands in our GD patients.…”

Section: Discussionmentioning

confidence: 47%

Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)

Scheinfeld¹,

Mones²

2006

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 47%

Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)

Scheinfeld¹,

Mones²

2006

Journal of the American Academy of Dermatology

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“…In 1984, Grover Regardless of the interesting work of many researchers, lack of knowledge of GD etiology persists. Initial reports suggested that poral occlusion of intraepidermal eccrine ducts might be implicated in the process, 8 but further studies have failed to confirm this possibility. 9 Despite of microscopic, immunohistochemical, 10 and ultrastructural 11 similarities of some GD lesions to Darier and Hailey-Hailey diseases, ATP2A2 gene mutations have not been found in GD.…”

Section: Discussionmentioning

confidence: 99%

Grover Disease: A Reappraisal of Histopathological Diagnostic Criteria in 120 Cases

Fernández‐Figueras

Puig²,

Cannata³

et al. 2010

The American Journal of Dermatopathology

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Grover disease (GD) is a rather common papular pruritic dermatosis that can be transient, persistent, or asymptomatic. The microscopic diagnosis of clinically suspected lesions can be challenging because GD can adopt different patterns, and involved areas are generally admitted to be mostly focal. The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well. In this study of 120 consecutive cases of GD, we have found a sex and age incidence similar to what has been previously described, with no obvious seasonal influence, but careful evaluation of their microscopic features suggests that the histopathological diagnostic criteria of GD should be expanded. Specifically, in addition to the commonly described GD findings, we have detected cases with porokeratosis-like oblique columns of parakeratosis, lesions showing a nevoid or lentiginous silhouette, intraepidermal vesicular lesions, lichenoid changes with basal vacuolization and dyskeratosis, and dysmaturative foci with keratinocyte atypia. Moreover, quite often the dermal infiltrate was composed not only of lymphocytes intermingled with eosinophils, but also of neutrophils. In many cases, the capillary vessels showed hints of vascular damage including endothelial tumefaction due to cytoplasmatic edema and erythrocyte extravasation. Finally, because involved areas were larger than 2 mm in more than 50% of our cases, we should assume that GD lesions are not always as small as commonly claimed. Awareness of the patterns newly described herein may be important to avoid underdiagnosis of GD and may contribute to understand the pathogenesis of this acantholytic disease.

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“…They suggested that occlusion of eccrine duct outflow causes intraepidermal spillage of sweat contents and is responsible for the development of the disease. Hashimoto et al (11,12) described three cases of Grover's disease precipitated by heat, sweating or being bed-ridden in which the acanthoiysis appeared to be related to eccrine outflow tracts and also suggested that spillage of sweat contents may be responsible for the development of the acantholytic process in this subgroup of patients. However, histological studies and immunohistochemical studies for sweat duct specific antibodies have provided mixed results in support of this hypothesis (11)(12)(13)(14).…”

mentioning

confidence: 99%

Grover's disease (transient acantholytic dermatosis): relationship of acanthoiysis to acrosyringia

et al. 1998

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Transient acantholytic dermatosis is often associated with excessive sweating, fever, and bed confinement. The pathogenesis of this disease has been postulated to be poral occlusion of damaged eccrine intraepidermal ducts. Histological and immunohistochemical and ultrastructural studies were performed on 10 biopsies from 10 patients with transient acantholytic dermatosis. Immunoreactions for carcinoembryonic antigen and cytokeratin-7 to identify eccrine duct epithelium were performed on all 11 biopsies. In addition, 5 of the biopsies were immunoreacted for cytokeratin 8. All immunoreactions were reviewed independently by two observers to determine extent of reactivity and whether it correlated with areas of epidermal acantholysis. Among the 11 biopsies, 8 showed acantholysis not associated with eccrine duct outflow tracts. In 2 biopsies the acantholysis was consistently associated with acrosyringea; in one case acantholysis was inconsistently associated with eccrine outflow tracts. Epidermal acantholysis in patients with Grover's disease is associated with the outflow tracts of eccrine ducts in a subgroup of patients. Although leakage of sweat from occluded sweat ducts in acrosyringia may be the mechanism operating in a subgroup of patients with Grover's disease, this does not appear to be the subgroup of patients in whom Grover's disease develops in the setting of being bedridden and/or sweating.

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Sudoriferous acrosyringeal acantholytic disease

Cited by 23 publications

References 29 publications

Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)

Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)

Grover Disease: A Reappraisal of Histopathological Diagnostic Criteria in 120 Cases

Grover's disease (transient acantholytic dermatosis): relationship of acanthoiysis to acrosyringia

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