Sufentanil in combination with low-dose hyperbaric bupivacaine in spinal anesthesia for cesarean section: a randomized clinical trial

Dourado, Alexandre Dubeux; Filho, Ruy Leite de Melo Lins; Fernandes, Raphaella Amanda Maria Leite; Gondim, Marcelo Cavalcanti de Sá; Nogueira, Emmanuel Victor Magalhães

doi:10.1016/j.bjane.2015.05.002

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…In our study, the frequency of itching in F group was higher than S and P groups (P = 0.003). Motiani et al ( 26 ) and Dourado et al ( 31 ) mentioned higher frequency of itching in sufentanil group than other groups. Although Braga et al ( 21 ) mentioned no significant difference in the incidence of itching between the 2 groups as well, itching was much more noted in sufentanil group, and this result was inconsistent with ours.…”

Section: Discussionmentioning

confidence: 93%

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

et al. 2017

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BackgroundSpinal anesthesia is the method of choice for most elective and emergency Cesarean sections. To increase the duration of anesthesia and improve the quality of analgesia during and after surgery, intrathecal opioids, as adjuvant drugs, are used in combination with local anesthetics.MethodsThis was a double-blind clinical trial performed on 99 patients. Women were divided into 3 groups of fentanyl, sufentanil, and placebo. For fentanyl group, 12.5 mg of bupivacaine and 25 micrograms of fentanyl; for sufentanil group, 12.5 mg of bupivacaine and 2.5 micrograms of sufentanil; and for placebo group, 12.5 mg of bupivacaine and a half mL of normal saline were injected in subarachnoid space. The sensory and motor block, hemodynamic status (mean blood pressure and heart rate), and probable complications were assessed.ResultsThere was no significant difference between the groups in demographic characteristics. Durations of analgesia were, respectively, 314 ± 42.95, 312.5 ± 34.44, and 116.1 ± 42.24 minutes in the fentanyl, sufentanil, and placebo groups (P = 0.0001). Duration of sensory and motor block was higher in fentanyl and sufentanil groups compared with the placebo group. The highest duration of sensory and motor block was noted in sufentanil group (P = 0.0001). No significant difference was found between the groups in the hemodynamic parameters (P > 0.05). The frequency of itching in the fentanyl group was higher than sufentanil and placebo groups (P = 0.003). Also, shivering was higher in the placebo group compared with other groups (P = 0.036).ConclusionsAccording to the results, adding 25 microgram fentanyl or 2.5 microgram sufentanil to intrathecal bupivacaine increased the duration of analgesia and provided hemodynamic stability with no major complication. As administering intrathecal fentanyl had a similar duration of analgesia like sufentanil with faster return of motor block and ambulation, it seems that it is a preferred additive for Cesarean section surgery.

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Section: Discussionmentioning

confidence: 93%

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

et al. 2017

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“…If the percentages of patients with Th2-Th4 dermatome were too high, the incidence of hypotension after induction of spinal anesthesia for C-section would increase. On the other hand, the high level of block height Th2 dermatome would inhibit the cardiac function, leading to decreased cardiac output [2]. Therefore, under such high incidence of hypotension and decreased cardiac function setting, spinal anesthesia rCBV and rCBO after induction of spinal anesthesia being probably dependent on the decrease in SVR might be not accurate.…”

Section: To the Editormentioning

confidence: 99%

“…It is well known that, to obtain adequate anesthesia for cesarean section (C-section), an intense blockade covering from the sacral (S2-S4) to the visceral fibers (T4-T12) is needed [2]. A blockade with such extension results in hypotension by blocking the sympathetic fibers.…”

Section: To the Editormentioning

confidence: 99%

It was not accurate

Yang

Zhang

2019

J Anesth

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“…The correlation between the local anesthetic (LA) dose used in spinal anesthesia and the occurrence of maternal side effects is well recognized (1). However, the reduction of LA dosage leads to increased incidence of intraoperative pain (1)(2)(3). Several drugs have been adjusted to local anesthetics to induce sufficient analgesia with lesser side effects, such as opioids, midazolam, epinephrine, ketamine, clonidine, magnesium and gabapentin (4,5).…”

Section: Introductionmentioning

confidence: 99%

Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study

Khezri

Rajabi

Yaghobi

et al. 2019

J Adv Med Biomed Res

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10.30699/jambs.27.123.23 Background & Objective: Nowadays, conventional analgesic agents that are usually used for pain killing after cesarean sections do not provide enough analgesia with infrequent serious side effects. Lidocaine has been suggested as an adjuvant analgesic agent for postoperative pain relief. We designed this randomized doubleblind, placebo-controlled study to evaluate the analgesic efficacy of intravenous lidocaine in patients undergoing a cesarean section under spinal anesthesia. Materials & Methods: Eighty patients undergoing elective cesarean section under spinal anesthesia were randomly divided into two groups to receive intravenous 1.5 mg/kg of lidocaine 2% bolus 15 minutes prior to spinal anesthesia followed by an intravenous infusion of 1.5 mg/kg/h for 60 minutes (L group) or 0.9% sodium chloride (C group) in a double-blind fashion. The time until the first request for an analgesic, the duration of sensory and motor blockade, hemodynamic variables and adverse events were recorded. Results: The difference in sensory (95% CI 10.18 to 18.01; P≤0.001) and motor (95% CI 35.50 to 50.19; P≤0.001) blockade durations between groups L and C were significant. Similarly, the mean time until the first analgesic request was longer in group L (175.37±21.43) than in group C (157.12±15.25); the difference between the two groups was significant (95% CI9.95 to 26.54; P<0.001). Conclusion: Intravenous lidocaine given as a supplementary agent in patients undergoing cesarean section under spinal anesthesia prolonged the duration of the sensory and motor blockade of spinal anesthesia and delayed the first analgesic request by patients without hemodynamic disturbance, respiratory depression and compromising the fetus.

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Sufentanil in combination with low-dose hyperbaric bupivacaine in spinal anesthesia for cesarean section: a randomized clinical trial

Cited by 12 publications

References 14 publications

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

It was not accurate

Analgesic Efficacy of Intravenous Lidocaine Infusion in Cesarean Section under Spinal Anesthesia: A Prospective Randomized Double-Blind Study

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