SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway

Abstract

The aim of the present study was to investigate the function and mechanism of SUFU in treatment of pancreatic cancer. Patient with pancreatic cancer (n = 50) and normal volunteers (n = 30) were obtained from The Second Affiliated Hospital of Soochow University between May 2014 and April 2013. SUFU mRNA and protein expressions in patients with pancreatic cancer were reduced as compared to normal saline. OS and DFS of high expression of SUFU in pancreatic cancer were higher than those of low expression of SUFU in pancreatic cancer. The inhibition of SUFU promoted pancreatic cancer cell growth and migration; SUFU reduced pancreatic cancer cell growth and migration. SUFU suppressed Wnt/β-catenin signaling pathway in pancreatic cancer cell lines. SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway, providing a novel possibility for an understanding of pancreatic cancer pathogenesis.