Sugammadex, rocuronium and mast cell numbers in the rat liver

Platt, Peter; Sadleir, P. H. M.; Clarke, Russell C.

doi:10.1111/anae.12106

Cited by 2 publications

(2 citation statements)

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“…For this reason, it has been reported that it causes histopathological findings such as skeletal muscle myopathy, vacuolization, pyknotic nuclei clumps, and thus causes disorders such as weakening of muscle fibers and hypertrophy (14). Since sugammadex is excreted from the kidneys and is not metabolized in the liver (15), there are a limited number of studies including its effect on liver morphology and enzymes (16). Clarke et al (17) reported that a cutaneous anaphylaxis effect in patients sensitive to rocuronium was alleviated with sugammadex after two minutes.…”

Section: Introductionmentioning

confidence: 99%

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

Annaç¹,

ULUDAĞ²,

Doğan³

2022

JECM

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Selectively steroidal neuromuscular blocking agents, such as rocuronium, are required to maintain surgical procedures. It is a sugammadex γ-cyclodextrin-derived drug that encapsulates these drugs and reverses its effects. In the present study, it was aimed to investigate the effects of sugammadex rocuronium complex on liver and possible toxic effects on hepatocytes using histopathological and biochemical methods. In the current study, 32 adult Sprague - Dawley male rats were used. Four groups were designed as pure control, control group, sugammadex and sugammadex-rocunorium. Following the experimental procedures, liver tissues extracted from rats were stained after routine histological procedures. The images were taken from the sections for histopathological evaluation. For biochemical analysis, glutathione (GSH) and malondialdehyde (MDA) enzymes were analyzed in the liver tissues. In the group treated with the sugammadex-rocunorium complex, caspase-3 expressions were observed to be higher than in other groups. In addition, while the amount of GSH belonging to sugammadex and sugammadex-rocunorium groups decreased compared to the control group, an increase in MDA amount was found. Sugammadex-rocunorium can lead to oxidative stress in the hepatocytes. However, more studies are needed to reveal the toxic effects of sugammadex and sugammadex and rocunorium complex in the liver.

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Section: Introductionmentioning

confidence: 99%

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

Annaç¹,

ULUDAĞ²,

Doğan³

2022

JECM

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“…In‐vitro and in‐vivo human models of anaphylaxis have not been able to demonstrate immunologically mediated attenuation of established anaphylaxis . We have raised theoretical objections about the plausibility of any such immunologically mediated benefits . For both ethical and practical reasons, a controlled clinical trial investigating this use of sugammadex in humans is unlikely.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of sugammadex in rocuronium‐induced or antibiotic‐induced anaphylaxis. A case–control study

et al. 2015

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SummaryWe report 13 cases of presumed rocuronium-induced anaphylaxis in which sugammadex was administered with the intention of reversing the immunological reaction. Of these 13 cases, eight (62%) were later confirmed to be type-1 hypersensitivity reactions to rocuronium, three (23%) were triggered by an antibiotic and two (15%) were non-immunologically mediated. Response to treatment was scored by the treating anaesthetist, and compared with haemodynamic and inotrope measurements from the resuscitation and anaesthetic records. Haemodynamic improvement was seen in only six (46%) cases, three of which were associated with a non-rocuronium trigger. Of the three cases in which the treating anaesthetist thought that sugammadex had been beneficial, one was not caused by rocuronium, one had no improvement in blood pressure and one required 8.5 times as much adrenaline in boluses after, compared with the period before, sugammadex administration. These data suggest that sugammadex does not modify the clinical course of a suspected hypersensitivity reaction.

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Sugammadex, rocuronium and mast cell numbers in the rat liver

Cited by 2 publications

References 5 publications

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

Efficacy of sugammadex in rocuronium‐induced or antibiotic‐induced anaphylaxis. A case–control study

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