Sugar-Core Synthesized Multibranched Polylactic Acid and Its Diacrylate Blends as a UV LED-Curable Coating with Enhanced Toughness and Performance

Piroonpan, Thananchai; Booncharoen, Kasidit; Pasanphan, Wanvimol

doi:10.1021/acssuschemeng.2c02958

Cited by 4 publications

(2 citation statements)

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“…As a natural intermediary in carbohydrate biosynthesis, the biodegradable and biocompatible polymer PLA splits into monomeric units of lactic acid in the human body . Solvent evaporation, displacement, and diffusion have often been used to create PLA. − The salting-out process is characterized by the addition of compounds, such as MgCl 2 and CaCl 2 to separate them into water-miscible and immiscible solvent layers. The principal benefit of salting out is that it reduces the burden on protein capsules …”

Section: Classification Of Biodegradable Polymersmentioning

confidence: 99%

Toxicity of Polymeric Nanodrugs as Drug Carriers

Sairam,

Sanmugam,

Pushparaj

et al. 2023

ACS Chem. Health Saf.

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The ambiguity of certain diseases and the potential toxicity of many medications have sparked demand for the incorporation and enhancement of drug delivery systems (DDSs). Nanomedicine has received renewed attention in modern medical advancements with therapeutic uses. Therefore, the development of nanomedicines for enhanced bioaccessibility, long drug administration, and dose reduction has advanced as a unique concept. Nanocapsules, nanoemulsions, drug nanocrystals, micelles, solid lipid nanoparticles (SLNs), and polymeric nanoparticles (poly-NPs) are among the most effective nanomedicine techniques. Poly-NPs have emerged as a potential method to enhance drug pharmacokinetics. Pharmaceutical potency can be increased by using nanocarriers and medication formulations. The potential of poly-NPs to alter contemporary medicine has attracted significant interest; polymer adaptability makes them suitable for site-specific drug delivery requirements. However, little is known about their safety in long-term studies using high-pitched doses. These cells exhibit some extrapyramidal symptoms (EPS) because of the reactivity and size reduction of the polymers chosen by using living cells other than the target. With an increased understanding of polymers and their properties, it is equally important to emphasize the safety and toxicity of DDSs. Some of the toxic effects of polymeric nanodrugs include an increase in the cytotoxicity of the cell, reduction in the feasibility of the cell, increase in the rate of programmed cell death (apoptosis), precursors for tumor formation, DNA destruction, gene toxicity, rupture of the cell membrane, and lipid peroxidation reactions. In this article, we discuss the toxicity of nanoparticles (NPs) used in DDSs, including polylactide-co-glycolide, polylactic acid, polycaprolactone, and poly(alkyl cyanoacrylates), used in DDSs.

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Section: Classification Of Biodegradable Polymersmentioning

confidence: 99%

Toxicity of Polymeric Nanodrugs as Drug Carriers

Sairam,

Sanmugam,

Pushparaj

et al. 2023

ACS Chem. Health Saf.

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“…While sugars are the most abundant small molecules sourced from biomass, their use in materials has been limited to minority components as additives and excipients or as feedstock for chemical synthesis of polymers. ,− In some instances, sugars have been manipulated as a material for sacrificial molds, shattering objects, and edible food coatings or packaging, which specifically target the brittle or water-soluble nature of pure sugar. − The combination of sugars and additives to create robust (i.e., not fragile) materials has been largely unexplored. Herein, we introduce this type of material, where shaped objects can be made quickly via injection molding (just like plastics) and where the materials are designed to withstand transportation, storage, and use in commodity applications rather than as ephemeral structures or edible products.…”

Section: Introductionmentioning

confidence: 99%

Amorphous Sugar Materials as Sustainable and Scalable Alternatives for Rigid, Short-Term-Use Products

Miller-Cassman

Nogales

Phillips

2023

ACS Sustainable Chem. Eng.

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Plastics are the prevailing materials for short-term-use applications, despite being designed to last far longer than often is needed or desired. This article describes a class of materials that are formed from small-molecule sugars, rather than polymers, as a scalable and environmentally friendly replacement for rigid thermoplastics for short-term-use applications. The materials use amorphous isomalt as a matrix and natural additives to tune the mechanical properties. Like plastics, this class of materials is lightweight and can be produced efficiently at low temperatures via injection molding, yet the materials emulate the rigidity and strength of ceramics and stones. Repeated recycling is achieved via a closed-loop process without degradation of the isomalt binder and without loss of mechanical properties. Finally, these materials are resistant to water for hours when coated, yet ultimately dissolve within minutes when broken, with the resulting products being nontoxic small-molecule and degradable biobased materials. This combination of traits makes amorphous isomalt materials suitable as an alternative to persistent plastics in short-term-use applications.

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