Sugar-sweetened Beverages and Chronic Kidney Disease

Abstract

Increasing consumption of sugar-sweetened beverages has occurred in parallel with the increasing prevalence of chronic kidney disease (CKD) in the US. Consumption of sugar-sweetened beverages, particularly with fructose, has been shown to play an important role in the pathogenesis of obesity, diabetes, hypertension, hyperuricemia, and nephrolithiasis, all of which are risk factors for CKD. However, the direct role of sugarsweetened beverages in the progression of CKD remains unclear. To date, five epidemiologic studies have examined the association between sugar consumption and kidney outcomes, with two showing statistically significant positive associations between higher sugar intake and adverse kidney outcomes. Even though the direct causal relationship between sugar-sweetened beverages and CKD has not been definitely established, it is advisable to counsel individuals with CKD and those at risk for CKD to limit the intake of sugar-sweetened beverages in light of its known detrimental effects on CKD risk factors. KeywordsSugar-sweetened beverages, chronic kidney disease, hyperuricemia -1995 and 1995-1999. 6 During both periods, weight gain was highest among participants who increased their sugar-sweetened beverage consumption from one or fewer drinks per week to one or more drinks per day (4.69 and 4.20 kg for the two periods, respectively) and lowest among participants who decreased their overall sugar-sweetened beverage intake (1.34 and 0.15 kg for the two periods, respectively). Likewise, Palmer and colleagues examined more than 40,000 women in the Black Women's Health Study and found that participants who increased their intake of sugar-sweetened

Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model

“…Some risk factors for this damage have been suggested, for example, environmental pollutants and sweetened beverages consumption. [2][3][4] Particulate matter (PM) is an atmospheric pollutant linked to several pathologies and is considered the 15th cause of global mortality. 5 In addition, associations between PM and reduced renal function 6 have been found.…”