Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study

Pacheco, Lorena S.; Anderson, Cheryl A.M.; Lacey, J.; Giovannucci, Edward; Lemus, Hector; Araneta, Maria Rosario G.; Sears, Dorothy D.; Talavera, Gregory A.; Martı́nez, Marı́a Elena

doi:10.1371/journal.pone.0223638

Cited by 32 publications

(36 citation statements)

References 42 publications

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“…Of 135 eligible articles, 71 were excluded due to the following reasons: 59 did not report risk index for sweet beverages and cancer incidence, 3 full-texts were not available, 7 considered other outcomes, 1 case-control study included controls with cancer at recruitment and 1 publication was not in English or Spanish. Finally, 64 studies were included in the systematic review, 27 cohort [ 23 , 24 , 28 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ] and 37 case-control studies [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ...…”

Section: Resultsmentioning

confidence: 99%

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

et al. 2021

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The consumption of sweet beverages, including sugar-sweetened beverages (SSB), artificial-sweetened beverages (ASB) and fruit juices (FJ), is associated with the risk of different cardiometabolic diseases. It may also be linked to the development of certain types of tumors. We carried out a systematic review and meta-analysis of observational studies aimed at examining the association between sweet beverage intake and cancer risk. Suitable articles published up to June 2020 were sourced through PubMed, Web of Science and SCOPUS databases. Overall, 64 studies were identified, of which 27 were selected for the meta-analysis. This was performed by analyzing the multivariable-adjusted OR, RR or HR of the highest sweet beverage intake categories compared to the lowest one. Random effects showed significant positive association between SSB intake and breast (RR: 1.14, 95% CI: 1.01–1.30) and prostate cancer risk (RR: 1.18, 95% CI: 1.10–1.27) and also between FJs and prostate cancer risk (RR: 1.03, 95% CI: 1.01–1.05). Although the statistically significant threshold was not reached, there tended to be positive associations for the following: SSBs and colorectal and pancreatic cancer risk; FJs and breast, colorectal and pancreatic cancer risk; and ASBs and pancreatic cancer risk. This study recommends limiting sweet beverage consumption. Furthermore, we propose to establish a homogeneous classification of beverages and investigate them separately, to better understand their role in carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

et al. 2021

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“…A conclusive link between high sugar intake and CRC risk in healthy humans has not been reported by cohort studies (Galeone et al, 2012;Tasevska et al, 2012;Pacheco et al, 2019), but a moderately heightened risk did emerge in smaller case-control studies (Pou et al, 2012;Wang et al, 2014;Chun et al, 2015). Nonetheless, the detrimental effect of simple carbohydrates on CRC is more evident in animal studies.…”

Section: Simple Carbohydratementioning

confidence: 92%

Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

Loke

Chew

Ngeow

et al. 2020

Front. Cell. Infect. Microbiol.

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Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red processed meats, alcohol, and low dietary fiber content. There is growing evidence of the interplay between diet and gut microbiota in CRC carcinogenesis. Although there appears to be a direct causal role for gut microbes in the development of CRC in some animal models, the link between diet, gut microbes, and colonic carcinogenesis has been established largely as an association rather than as a cause-and-effect relationship. This is especially true for human studies. As essential dietary factors influence CRC risk, the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also discussed. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damage can all influence dysbiosis and consequently CRC carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components toward promoting a colonic neoplasm together with interacting with gut microbiota. It follows that dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk.

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“…Eight publications reported data on colorectal cancer, four case control [87][88][89][90] and four cohort studies [22,51,53,55]. A borderline positive association was observed with SBB intake using the random-effect model (RR: 1.18, 95% CI: 0.99 -1.41), but it reached the significance using the fixed-effect model (RR: 1.19, 95% CI: 1.02 -1.39) ( Figure S1).…”

Section: Sweet Beverages and Risk Of Intestinal And Colorectal Cancermentioning

confidence: 99%

“…Therefore, they were classified at moderate risk of bias. Only one study [49] was classified as moderate bias in the outcome measurement, and another [55] in the selection of reported outcomes.…”

Section: Quality Of Included Studiesmentioning

confidence: 99%

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

Llaha¹,

Gil-Lespinard²,

Unal³

et al. 2020

Preprint

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The consumption of sweet beverages, including sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB) and fruit juices (FJ) is associated with the risk of different cardiometabolic diseases and probably with some tumors as well. We carried out a systematic review and meta-analysis of observational studies aimed at evaluating the association between sweet beverage intake and different types of cancer risk. Suitable papers published up to June 2020 were searched through PubMed, Web of Science and SCOPUS databases, using relevant keywords. Overall, 64 studies were identified for the systematic review, of which 27 were selected for the meta-analysis. This was performed by analyzing the multivariable-adjusted OR, RR or HR of the highest compared with the lowest sweet beverage intake categories. Random effects showed significant positive association between SSBs intake and breast (RR: 1.14, 95% CI: 1.01 – 1.30) and prostate cancer risk (RR: 1.18, 95% CI: 1.10 – 1.27), also between FJs and prostate cancer risk (RR: 1.03, 95% CI: 1.01 – 1.05). Associations between SSBs and colorectal and pancreatic cancer risk, FJs and breast, colorectal and pancreatic cancer risk, ASBs and pancreatic cancer risk tended to be positive but did not reach the statistically significant threshold. This study supports the recommendation to limit the consumption of SSBs and FJs for cancer prevention and proposes to further investigate the potential harmful role of ASBs intake in cancer risk.

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Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study

Cited by 32 publications

References 42 publications

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies

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