Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

Abstract

Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and dissolution rates of poorly soluble drugs when employed as carriers in solid dispersions (SDs). However, synthetic polymers dominate the preparation of drugs: excipient SDs have been created in recent years, but these polymer-based SDs exhibit the major drawback of recrystallisation upon storage. Also, the use of high-molecular-weight polymers with increased chain lengths brings forth problems such as increased viscosity and unnecessary bulkiness in the resulting dosage form. An ideal SD carrier should be hydrophilic, non-hygroscopic, have high hydrogen-bonding propensity, have a high glass transition temperature (Tg), and be safe to use. This review discusses sugars and polyols as suitable carriers for SDs, as they possess several ideal characteristics. Recently, the use of low-molecular-weight excipients has gained much interest in developing SDs. However, there are limited options available for safe, low molecular excipients, which opens the door again for sugars and polyols. The major points of this review focus on the successes and failures of employing sugars and polyols in the preparation of SDs in the past, recent advances, and potential future applications for the solubility enhancement of poorly water-soluble drugs.

Uso de Polioles en la Industria de la Confitería

“…Debido a su estructura, es extremadamente estable y presenta un bajo nivel de higroscopicidad, manteniéndose cristalino después de solidificarse, lo que permite incrementar la VU de los productos de confitería en donde es utilizado como parte de la formulación. Su grado de dulzura es aproximadamente del 60% en comparación con la sacarosa, y se emplea en la fabricación de chocolates y dulces con bajo contenido calórico (Hinkova et al, 2014;NPCS Board of Food Technologists, 2013;Poka et al, 2023).…”

Altering Mechanical and Dissolution Properties of Coffee Deposit by Adding Glucose

“…A sessile droplet is a crucial element, and its evaporation is a fundamental physical process in biomedical fabrication through droplet-based 2D and 3D printing. Sugar is a small biomolecule in many pharmaceutical formulations, acting as a binder, solubilizing agent, taste mask, and color carrier. ,− A coffee droplet serves as a well-known natural colloidal ink model system, forming a complex deposit film after evaporation. − Crack formation and propagation in the coffee-ring region are complex phenomena that occur during evaporation, playing a vital role in determining the mechanical stability of printed inks. ,, Cracks develop as the residual stress confined within evaporating colloidal droplets exceeds local strength thresholds, releasing internal stress. Primarily, capillary pressures induced by fluid menisci between colloidal particles on the surface of the coating film trigger cracking, entailing sudden exchanges of air and water.…”