Sugars as hydrogen-bond donors tune the phase behavior in a novel liquid–liquid biphasic system formed by hydrophilic deep eutectic solvents and n-propanol

Liu, Feng; Chen, Li; Yin, Kangling; Fan, Taotao; Yan, Zongcheng

doi:10.1016/j.fluid.2022.113393

Cited by 10 publications

(11 citation statements)

References 42 publications

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“…Based on lower mutual solubility with alcohol in aqueous medium, betaine showed a higher efficiency to form ATPS. Therefore, the presence of betaine could enlarge the biphasic area while the presence of xylitol led to a significant decline in the biphasic area …”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the presence of betaine could enlarge the biphasic area while the presence of xylitol led to a significant decline in the biphasic area. 29 Furthermore, the experimental data for the DES + alcohol + H 2 O systems were correlated by eq 1 proposed by Merchuk et al, and the constants (a, b, c), correlation coefficients (R 2 ), and standard deviations (σ) are depicted in Table 2. The fitted phase diagram for the DES/alcohol ATPS is shown in Figure 3.…”

Section: Journal Of Chemical and Engineeringmentioning

confidence: 99%

“…Furthermore, Ghaffari et al found that the drugs lamotrigine, salicylic acid, and acetaminophen could be completely separated using the ATPS constituted by choline chloride/fructose-based DES and PPG400. More recently, our team proposed the ATPS constituted by DES and small-molecular alcohols for the first time. − We prepared large amounts of DES using betaine and choline chloride as the HBA while sucrose, glucose, fructose, sorbitol, xylitol, urea, etc. as the HBD, and then focused on the influence of HBD properties on the efficiency to form ATPS.…”

Section: Introductionmentioning

confidence: 99%

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Liquid–Liquid Equilibrium Data for Novel Aqueous Two-Phase Systems Composed of Betaine-Xylitol Deep Eutectic Solvent + Alcohol (1-Propanol/2-Propanol/tert-Butanol) + Water

et al. 2022

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Focused on developing a biocompatible and ecofriendly extraction platform, aqueous two-phase systems (ATPS) containing betaine-xylitol deep eutectic solvent (DES), three smallmolecular alcohols (1-propanol, 2-propanol, and tert-butanol), and water were investigated here. The effect of alcohol properties on the efficiency to form ATPS with aqueous solution of DES was studied at 298.15 K and atmospheric pressure. The results suggested that the formation of the ATPS was attributed to the incompatibility between the DES and alcohol in aqueous medium, allowing the increase in the biphasic region using tert-butanol with the highest hydrophobicity among three alcohols. Combined with Karl Fischer titration, the high-performance liquid chromatography (HPLC) analysis was used to evaluate the tie-lines of the ATPS, and it was found that DES components were enriched in the lower phase while alcohol was transferred preferentially to the upper phase. Additionally, the increase in the concentrations of ATPS phase compositions was responsible for the increase in the length of tie-lines, which led to a higher driven force for phase separation. The detailed experimental data were highly correlated by the NRTL model based on a low root-mean-square deviation (≤1.79%). Moreover, five biomolecules (gallic acid, syringic acid, quercetin, kaempferol, and isorhamnetin) were used as probes to determine the extraction ability of the studied DES/alcohol ATPS. This work may lay a promising foundation for the diversity development of the ATPS.

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Section: Resultsmentioning

confidence: 99%

Section: Journal Of Chemical and Engineeringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liquid–Liquid Equilibrium Data for Novel Aqueous Two-Phase Systems Composed of Betaine-Xylitol Deep Eutectic Solvent + Alcohol (1-Propanol/2-Propanol/tert-Butanol) + Water

et al. 2022

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“…This result can be explained in terms of the differences in the interaction of the NADES and alcohol in aqueous solution. 29 When the NADES and the alcohol are mixed at the same time in an aqueous solution, the components of the NADES and alcohol would compete for the water molecule. Compared to alcohols, those components of the NADES have a stronger affinity for water molecules.…”

Section: Abs-eev Model Extended To the Sugar-based Des/alcohol Liquid...mentioning

confidence: 99%

“…Those works using EEV parameters to quantify the phase formation ability of the system with good results. A sugarbased NADES/alcohol ABS is a system formed by the interaction of the NADES and water-soluble alcohol in aqueous solution, 29 and this previous system has shown that the three kinds of sugars NADESs (choline chloride-Sucrose (ChCl-Suc), choline chloride-glucose (ChCl-Glu), and choline chloride-fructose (Chcl-Fru)) can form a ternary system with a hydrophilic n-propanol, because the molar ratio of HBA:HBD could be maintained in those systems. However, as a completely novel system, enormous challenges in the investigation of the phase formation mechanism of this system remain.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Phase Formation Mechanism of the Sugar-Based Natural Deep Eutectic Solvent + Water-Soluble Alcohol + Water Aqueous Biphasic System Based on the Excluded Volume Theory

et al. 2022

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To investigate the phase formation mechanism of sugar-based natural deep eutectic solvent (DES) aqueous biphasic systems, an excluded volume theory (EEV) model was extended to the sugar-based (sucrose, glucose, fructose)-choline chloride DES + tert-butyl alcohol and isopropyl alcohol + water systems. In this paper, phase density measurement of sugar-based natural deep eutectic solvents (NADESs) + water-soluble alcohols + water systems revealed that the densities of NADES-rich and alcohol-rich phase presented significant differences. On the basis of these results, a modified EEV model was correlated with the density and phase equilibrium data of each system. Subsequently, the parameters of the excluded volume obtained were used to quantify the interaction force between the NADES and alcohol, and the relationship between parameters and functional groups of phase components was used to explore the mechanism of phase formation and predict the possible liquid structure of the DES-rich phase. The analysis of the V a – DES – w * and f a – DES – w values showed that the interaction between the components of each system was influenced by the functional groups of hydrogen bond donors (HBDs) and alcohols, and it was beneficial to reduce the compatibility of the system and the space unfilled of tight packing of molecules by increasing the number of hydroxyl groups of HBDs and alkyl groups of alcohol, leading to improvement of the phase formation ability. From the analysis of the parameters given by the EEV model, the adjustment of the number of hydroxyl groups of HBDs and alkyl groups of alcohols was beneficial to regulate the biphasic coexistence region of sugar-based DES/alcohol systems.

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Sugaring-out plus salting-out: A novel separation and purification technique for biofuel

Sun,

Tan,

Zhou

et al. 2024

Fuel

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Sugars as hydrogen-bond donors tune the phase behavior in a novel liquid–liquid biphasic system formed by hydrophilic deep eutectic solvents and n-propanol

Cited by 10 publications

References 42 publications

Liquid–Liquid Equilibrium Data for Novel Aqueous Two-Phase Systems Composed of Betaine-Xylitol Deep Eutectic Solvent + Alcohol (1-Propanol/2-Propanol/tert-Butanol) + Water

Liquid–Liquid Equilibrium Data for Novel Aqueous Two-Phase Systems Composed of Betaine-Xylitol Deep Eutectic Solvent + Alcohol (1-Propanol/2-Propanol/tert-Butanol) + Water

Investigation of the Phase Formation Mechanism of the Sugar-Based Natural Deep Eutectic Solvent + Water-Soluble Alcohol + Water Aqueous Biphasic System Based on the Excluded Volume Theory

Sugaring-out plus salting-out: A novel separation and purification technique for biofuel

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