Sugars, lactic acid and pH in feces of children. A useful diagnostical approach for gastrointestinal disorders?

Schaub, J.; Lentze, Michael J.

doi:10.1007/bf00440539

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Chromatographic analyses confirmed the data in the literature (13). The quantity of sugar found was :0;;; 10 mg/g feces.…”

Section: Discussionsupporting

confidence: 86%

“…It has been previou sly show n tha t both te rm and preter m infa nts have some degree of carbohydrate ma labsorption (3)(4)(5)(6) . Th e incomplet e lactose abso rption during thi s period of life has been doc ume nted by measureme nt of fecal reducing substances, acidity, and suga r chromatography o n stools (13)(14)(15)(16). l ater studies using breath H 2 analysis co nfirme d these data .…”

Section: Discussionmentioning

confidence: 94%

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Sugar Absorption in Healthy Preterm and Full‐Term Infants

Roggero,

Mosca,

Motta

et al. 1986

J. pediatr. gastroenterol. nutr.

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Summary:We have studied carbohydrate absorption in 40 healthy term infants and 10 preterm neonates (31‐35 weeks gestation) by respiratory H2, fecal pH, and chromatographic analysis of stools. Sequential studies of H2 excretion (24‐h collection) in response to breast feeding were carried out in premature infants during the first 8 weeks of life. Five expired H2 during the first 2 weeks, and two continued to do so in the 3rd to 4th weeks. Breath H2 excretion fell below 10 ppm by 8 weeks and was not related to feeding or sleep. In term neonates, the frequency of incomplete carbohydrate absorption (4‐h test) at the end of the first week was 36% for 14 breast‐fed, 42% for 12 formula‐fed, and 64% for 14 mixed‐fed neonates (not significant differences). There were no significant differences between the absorbing and malabsorbing subjects in fecal pH. Chromatographic analysis showed only small quantities of sugars. In summary, incomplete carbohydrate absorption occurred in a high percentage of the newborns studied; the 24‐h test evaluated better than the 4‐h test; and negative breath H2 excretion indicated development of the capacity of the small intestine to hydrolyze carbohydrates. In the majority of the preterm malabsorbing babies, completely functional lactase occurs within the first month of life. The growth modulators in human milk may increase the rate of maturing of the small intestine.

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“…Chromatographic analyses confirmed the data in the literature (13). The quantity of sugar found was :0;;; 10 mg/g feces.…”

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 94%

Sugar Absorption in Healthy Preterm and Full‐Term Infants

Roggero,

Mosca,

Motta

et al. 1986

J. pediatr. gastroenterol. nutr.

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“…Galactose and glucose increased in A mice feces compared to C and CB mice. Fermentation of sugars by microbial species is well documented (Schaub and Lentze 1973; Koser and Saunders 1933) and sugars are an ideal carbon source for many bacterial strains (Brückner and Titgemeyer 2002). Glucose, catabolized by the Embden-Meyerhof-Parnas pathway, may be diminished in antibiotic-treated mice because of loss of important microbial enzymes (Macy et al 1978).…”

Section: Resultsmentioning

confidence: 99%

Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

et al. 2013

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Metabolic profiling of urine and fecal extracts, histological investigation of intestinal ilea, and fecal metagenomics analyses were used to investigate effects of prolonged antibiotic use in mice. The study provides insight into the effects of extended empiric antibiotic therapy in humans. Mice were administered a broad-spectrum antibiotic for four consecutive days followed by oral gavage with Clostridium butyricum, an opportunistic gram-positive pathogenic bacteria commonly isolated in fecal and blood cultures of necrotizing enterocolitis patients. Metagenomics data indicated loss of bacterial diversity after 4 days on antibiotics that was restored after removing antibiotic pressure. Histological analyses indicated damage to ileal villi after antibiotic treatment that underwent repair after lifting antibiotic pressure. Metabolic profiling confirmed intestinal injury in antibiotic-treated mice indicated by increased urinary trans-4-hydroxy-l-proline, a breakdown product of collagen present in connective tissue of ileal villi that may serve as a biomarker for antibiotic-induced injury in at risk populations.

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Past and present aspects of diarrheal disease in childhood. Clinical study and treatment

Guggenbichler

Stickler

1975

Infection

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The etiologic and pathophysiologic findings described in the first part of this paper have important consequences: The recognition of the specific etiology of diarrhea requires new laboratory methods: most of these, however, are technically easy to perform and do not require a large laboratory. A long-ranging consequence of this changed concept is a well-founded modification of therapy. The most important discovery was, that in a well balanced glucose electrolyte solution sodium and glucose enhance their absorption mutually and increase the absorption of water by solvent drag. Since in most acute diarrheas the mechanisms of absorption of glucose and electrolytes are retained this mechanism can be utilized for fast oral rehydration and reinstitution of normal intestinal homeostasis. Prompt institution of a diet consisting of the previously mentioned glucose-electrolyte solution usually prevents severe dehydration and the need for stationary treatment. The elimination of lactose and long chain fatty acids from the diet prevents continuation of the pathologic osmotic and chemical conditions in the intestine. Antibiotics are not indicated in acute diarrhea with the exception of diarrhea caused by enteroinvasive E. Coli or Shigella, in the case of Salmonella-gastroenteritis even contraindicated. Further research concentrates on the development of drugs for neutralisation of E. Coli enterotoxin and the prevention of diarrheas by development of effective vaccines.

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Sugars, lactic acid and pH in feces of children. A useful diagnostical approach for gastrointestinal disorders?

Cited by 7 publications

References 31 publications

Sugar Absorption in Healthy Preterm and Full‐Term Infants

Sugar Absorption in Healthy Preterm and Full‐Term Infants

Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy

Past and present aspects of diarrheal disease in childhood. Clinical study and treatment

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