Suggestion against an oro-oral, route of transmission for Helicobacter pylori infection: A seroepidemiological study in a rural area

Luzza, Francesco; Imeneo, Maria; Maletta, M; Paluccio, G; Nisticò, Salvatore; Costa, Maurimélia Mesquita da; Perticone, F; Cavaliere, Carla; Focà, Alfredo; Pallone, Francesco

doi:10.1016/s0016-5085(98)80844-5

Cited by 5 publications

(7 citation statements)

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“…Both of these reports about the regression of ITP after eradication of H. pylori are from Italian groups. Because the prevalence of H. pylori infection for the healthy population is high not only in Italy (reported as 63% in southern Italy) (Luzza et al, 1998) but also in Japan, we were interested to determine whether ITP could be affected by H. pylori in Japan.…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

et al. 2002

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Summary. The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 48 Japanese patients with autoimmune thrombocytopenic purpura (AITP), including 40 chronic idiopathic thrombocytopenic purpura (ITP) and eight secondary AITP, were investigated. H. pylori infection was found in 25 ITP patients (62AE5%) and in two secondary AITP (25%). H. pylori eradication was obtained in 19 of 19 infected ITP patients (100%), who were not in remission (platelets < 100 · 10 9 /l) at the time of infection assessment. During follow-up (median 14AE8 months), 12 of 19 H. pylori-eradicated patients (63AE2%) showed a significant increase in platelet count accompanied by a significant decrease of plateletassociated immunoglobulin G (IgG). This response was maintained in all responding patients throughout the follow-up period. However, two infected patients with secondary AITP did not show platelet increase after eradication. The assessment of H. pylori infection and its eradication should be attempted in ITP as this approach could be an effective strategy, at least for some of these patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

et al. 2002

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“…1/14 (7) 11.5 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) Eradication therapy also ineffective in 10 Hp Ϫ patients. …”

Section: Platelet Outcome In H Pylori-negative Patientsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] In 1998, Gasbarrini et al 2 reported a substantial increase in the platelet count in all 8 H pylori-positive adults with immune thrombocytopenic purpura (ITP) in whom H pylori was eradicated. Subsequent uncontrolled studies from Italy [3][4][5] and Japan [6][7][8] all showed an apparently higher-than-expected prevalence of H pylori 9,10 in patients with ITP. Furthermore, 38% 7 to 73% 4 of H pylori-positive patients with ITP achieved a partial or complete platelet recovery after H pylori eradication.…”

Section: Introductionmentioning

confidence: 99%

Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?

Michel

Cooper

Jean

et al. 2004

Blood

152

117

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To determine the prevalence of Helicobacter pylori (H pylori) infection in North American patients with immune thrombocytopenic purpura (ITP) and the effect of H pylori eradication on the platelet count, a prospective study was performed. Seventy-four patients aged 10 years and older (mean age of 41 years) with chronic ITP and a platelet count below 60 ؋ 10 9 /L were enrolled. H pylori infection was found in 22% of patients by means of a breath test and could not be predicted by gastrointestinal symptoms. H pylori-positive patients (52.5 years of age) were older than H pylori-negative patients (38.5 years of age; P ‫؍‬ .0035). Fifteen of the 16 H pyloripositive patients were treated and the bacteria was eradicated in 14 (93%). After 3 months, a significant response (platelet count > 50 ؋ 10 9 /L and doubling the initial count) was observed in only one patient. After a median follow-up of 11.5 months, none of the 14 patients had responded. Ten H pylori-negative patients treated with the same regimen also did not increase their platelet counts. In conclusion, unlike several previous reports, this study does not implicate H pylori in the pathogenesis of ITP since the prevalence of H pylori infection was low and eradication of H pylori did not positively influence the course of the ITP. (Blood.

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“…Materials and Methods. Intrafamilial infection rather than communityacquired infection has been proposed [18]; gastrooral infection was more favored than fecal-oral or oral-oral transmission [19][20][21]. Results.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and Hepatitis a Virus Infection in School‐Aged Children on Two Isolated Neighborhood Islands in Taiwan

Chen¹,

Hwang²,

et al. 2003

Helicobacter

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Background. The transmission routes of Helicobacter pylori and hepatitis A virus (HAV) infections have been extensively discussed in previous literature. However, whether H. pylori and HAV shared the same transmission pattern or not remains unclear. Lower socioeconomic status was recognized as a consistent risk factor to both infections. However, whether fecal‐oral transmission was a risk factor to both infections is still under debate. Materials and Methods. In 1996, we conducted a cross‐sectional study to evaluate the seroprevalence of antibody to H. pylori and HAV among the randomly selected school‐aged children (age between 13 and 15) on Green Island (n = 91) and Lanyu Island (n = 138) (two isolated neighborhood islands near Taiwan Main Island). Results. The seroprevalence of H. pylori and HAV on the Green Island were 82.4% and 5.5%, respectively. The seroprevalence of H. pylori and HAV on Lanyu Island were 71.0% and 90.6%, respectively. H. pylori seroprevalence of all children and the subgroup of 13‐year‐olds was significantly lower on Lanyu Island than Green Island. However, it was not significantly different in subgroups of 14‐ and 15‐year‐olds. HAV seroprevalence was significantly higher on Lanyu Island than Green Island among all children and in each age subgroup. The correlation of H. pylori infection and HAV infection did not demonstrate significant linear correlation on both islands. Conclusions. In conclusion, H. pylori and HAV infections in school‐aged children of 13–15 years of age on Green Island and Lanyu Island did not demonstrate significant correlation. The results of this study imply that H. pylori and HAV may share different transmission routes of infection.

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Suggestion against an oro-oral, route of transmission for Helicobacter pylori infection: A seroepidemiological study in a rural area

Cited by 5 publications

References 0 publications

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?

Helicobacter pylori and Hepatitis a Virus Infection in School‐Aged Children on Two Isolated Neighborhood Islands in Taiwan

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