Currently, in mechanized tunneling, the steering of tunnel boring machines (TBM) in practice is mainly decided based on engineering expert knowledge and recorded monitoring data. In this chapter, a new concept of exploiting the advantages of simulation models to support the steering phase is presented, which allows optimizing the construction process. With the aim to support the steering decision during tunnel construction by means of real-time simulations, predictive simulation models are established in the initial planning phase of a tunnel project. The models are then capable of being continuously updated with monitoring data during the construction. The chapter focuses on explaining models for real-time predictions of logistics processes and tunneling induced settlements as well as the risk of building damage in more details. Additionally, application examples, which are practical-oriented, are also presented to illustrate the applicability of the proposed concept.