2010
DOI: 10.1016/j.eplepsyres.2009.09.022
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Suggestive evidence for a new locus for epilepsy with heterogeneous phenotypes on chromosome 17q

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Cited by 14 publications
(12 citation statements)
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“…The Cacng1 gene expressed in human fetal and adult brain [43] and developing mouse cerebellum [44]. A mutation of this gene was also proposed as a candidate for epilepsy [45] and its expression in hippocampal CA1 is altered in drug-induced epilepsy [46]. Another common DE gene, F2rl2 (Par3) belongs to an important subfamily of GPCRs, that are correlated with various phases of neurodevelopment [47,48,49,50], including axon-dendrite differentiation [51].…”
Section: Discussionmentioning
confidence: 99%
“…The Cacng1 gene expressed in human fetal and adult brain [43] and developing mouse cerebellum [44]. A mutation of this gene was also proposed as a candidate for epilepsy [45] and its expression in hippocampal CA1 is altered in drug-induced epilepsy [46]. Another common DE gene, F2rl2 (Par3) belongs to an important subfamily of GPCRs, that are correlated with various phases of neurodevelopment [47,48,49,50], including axon-dendrite differentiation [51].…”
Section: Discussionmentioning
confidence: 99%
“…The 17q12 locus has been linked with generalized epilepsies and febrile seizures, as well as with migraines comorbid in Rolandic epilepsy (Sirén et al. 2010; Hardies et al. 2013; Addis et al.…”
Section: Discussionmentioning
confidence: 99%
“…This locus is also not known to influence other common epilepsies. However, there is suggestive evidence for linkage of multiple seizure types at 17q22 (multipoint LOD 2.7) in a rare Finnish pedigree (Siren et al ). The maximum LOD in the Finnish pedigree was obtained at D17S1606, a marker we did not type but which is only 130 kb away from D17S957, a linked marker in our study.…”
Section: Discussionmentioning
confidence: 99%