Suicidal Behavior in Dementia

Sabodash, Valeriy; Mendez, Mario F.; Fong, Sylvia S.; Hsiao, Julia J.

doi:10.1177/1533317513494447

Cited by 31 publications

(7 citation statements)

References 40 publications

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“…Tanaka et al (2015) also stratified by disease severity, reporting depressive symptoms in 41.8% of mild, 47.1% of moderate, and 25% of severe dementia. Of the remaining eight studies, two reported symptoms in less than a quarter of people (Atkins et al , 2012; Sabodash et al , 2013), five found symptoms in between one quarter and one half of people (Ballarini et al , 2016; Clark et al , 1998; Panegyres et al , 2014; Toyota et al , 2007), and one study reported symptoms in just over half of cases (van Vliet et al , 2013). Reported prevalence of depressive symptoms appeared fairly consistent across three PPA studies, with a range of 38.2–43.4% (Chow et al , 2002; Fatemi et al , 2011; Medina and Weintraub, 2007).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer’s disease, and inherited dementia

Collins

Henley

Suárez‐González

2020

Int. Psychogeriatr.

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Objectives: Depression, anxiety, and apathy are the most commonly reported neuropsychiatric symptoms (NPS) in Alzheimer’s disease (AD). Understanding their prevalence in rarer dementias such as frontotemporal dementia (FTD), primary progressive aphasia (PPA), posterior cortical atrophy (PCA), young-onset AD (YOAD), and inherited dementias has implications for both clinical practice and research. In this study, we aimed to examine the current state of knowledge of the prevalence of these three NPS in less prevalent dementias. Design: We conducted a systematic review based on searches of EMBASE, PsycINFO, and PubMed up to September 2019. Results: 47 articles meeting inclusion criteria were identified. Depression, anxiety, and apathy were commonly reported across the phenotypes studied but their prevalence showed large variation between studies. Apathy showed the highest reported frequency in FTD (50–100% across studies), behavioral variant frontotemporal dementia (bvFTD) (73–100%), and YOAD (44–100%). Anxiety was frequently reported in FTD (0–100%) and bvFTD (19–63%). Depression showed the highest prevalence in FTD (7–69%) and YOAD (11–55%). Among the three variants of PPA, sv-PPA is the one most investigated (seven articles). Three or fewer articles were identified examining NPS in the remaining PPA variants, PCA, familial AD, and familial FTD. Inconsistency in the tools used to measure symptoms and small sample sizes were common methodological limitations. Conclusions: Future studies should consider the inclusion of larger sample sizes (e.g. through multicenter collaborations) and the use of harmonized protocols that include the combination of caregiver and patient-derived measures and symptom-specific questionnaires. More research is needed on the phenotype-specific barriers and facilitators for people living with dementia to successfully engage in self-reports of NPS.

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Section: Resultsmentioning

confidence: 99%

A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer’s disease, and inherited dementia

Collins

Henley

Suárez‐González

2020

Int. Psychogeriatr.

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“…In contrast, patient levels of depression were not correlated with caregiver burden in SD (R > L) patients, although more than half of these individuals were depressed. Sabodash et al [ 29 ] suggested that SD patients have a higher risk of suicide, especially those with depression and insight about their disease. With respect to depression in SD (L > R) and SD (R > L), more detailed research is needed, including an examination of the relationship between patient levels of depression and caregiver burden.…”

Section: Discussionmentioning

confidence: 99%

Caregiver Burden in Semantic Dementia with Right- and Left-Sided Predominant Cerebral Atrophy and in Behavioral-Variant Frontotemporal Dementia

Koyama

Hashimoto

Fukuhara

et al. 2018

Dement Geriatr Cogn Disord Extra

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Background: Caregiver burden is a serious concern for family caregivers of dementia patients, but its nature is unclear in patients with semantic dementia (SD). This study aimed to clarify caregiver burden for right- (R > L) and left-sided (L > R) predominant SD versus behavioral-variant frontotemporal dementia (bvFTD) patients. Methods: Using the Japanese version of the Zarit Burden Interview (ZBI) and the Neuropsychiatric Inventory, we examined caregiver burden and behavioral and psychological symptoms of dementia (BPSD) in 43 first-visit outpatient/family caregiver dyads (bvFTD, 20 dyads; SD [L > R], 13 dyads; SD [R > L], 10 dyads). Results: We found a significant difference in ZBI score between the 3 diagnostic groups. Post hoc tests revealed a significantly higher ZBI score in the bvFTD than in the SD (L > R) group. The ZBI scores in the SD (L > R) and SD (R > L) groups were not significantly different, although the effect size was large. Caregiver burden was significantly correlated with BPSD scores in all groups and was correlated with activities of daily living and instrumental activities of daily living decline in the bvFTD and SD (R > L) groups. Conclusion: Caregiver burden was highest in the bvFTD group, comparatively high in the SD (R > L) group, and lowest in the SD (L > R) group. Adequate support and intervention for caregivers should be tailored to differences in caregiver burden between these patient groups.

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“…Patients suffering from organic mental disorders who previously underwent inpatient treatment complete suicide 10 times more often than outpatients [ 12 ]. Among ICD-10 F0 diagnoses, dementia constitutes a moderate risk if not more [ 99 , 100 , 101 , 102 , 103 , 104 ], including pre-emptive suicide [ 105 , 106 ].…”

Section: Suicide and Mental Illnessmentioning

confidence: 99%

Epidemiology of Suicide and the Psychiatric Perspective

Bachmann

2018

IJERPH

1,035

646

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Suicide is a worldwide phenomenon. This review is based on a literature search of the World Health Organization (WHO) databases and PubMed. According to the WHO, in 2015, about 800,000 suicides were documented worldwide, and globally 78% of all completed suicides occur in low- and middle-income countries. Overall, suicides account for 1.4% of premature deaths worldwide. Differences arise between regions and countries with respect to the age, gender, and socioeconomic status of the individual and the respective country, method of suicide, and access to health care. During the second and third decades of life, suicide is the second leading cause of death. Completed suicides are three times more common in males than females; for suicide attempts, an inverse ratio can be found. Suicide attempts are up to 30 times more common compared to suicides; they are however important predictors of repeated attempts as well as completed suicides. Overall, suicide rates vary among the sexes and across lifetimes, whereas methods differ according to countries. The most commonly used methods are hanging, self-poisoning with pesticides, and use of firearms. The majority of suicides worldwide are related to psychiatric diseases. Among those, depression, substance use, and psychosis constitute the most relevant risk factors, but also anxiety, personality-, eating- and trauma-related disorders as well as organic mental disorders significantly add to unnatural causes of death compared to the general population. Overall, the matter at hand is relatively complex and a significant amount of underreporting is likely to be present. Nevertheless, suicides can, at least partially, be prevented by restricting access to means of suicide, by training primary care physicians and health workers to identify people at risk as well as to assess and manage respective crises, provide adequate follow-up care and address the way this is reported by the media. Suicidality represents a major societal and health care problem; it thus should be given a high priority in many realms.

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Suicidal Behavior in Dementia

Abstract: Patients with SD are at special risk of committing suicide, particularly if they have depression and preserved insight. Possible mechanisms include an impaired sense of semantic competence with increased impulsivity.

Cited by 31 publications

References 40 publications

A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer’s disease, and inherited dementia

A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer’s disease, and inherited dementia

Caregiver Burden in Semantic Dementia with Right- and Left-Sided Predominant Cerebral Atrophy and in Behavioral-Variant Frontotemporal Dementia

Epidemiology of Suicide and the Psychiatric Perspective

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