Suicidal behaviour and lipid levels in unipolar and bipolar depression

Ainiyet, Babajohn; Rybakowski, Janusz

doi:10.1017/neu.2014.18

Cited by 28 publications

(20 citation statements)

References 27 publications

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“…This corroborates the results of a previous Polish study performed by Rabe-Jablonska and Poprawska [9] in patients with acute depressive episodes, in which lower levels of total and LDL cholesterol were observed in those with suicidal behavior. Also, in one of our own previous investigations, a significant association was found between low total cholesterol, LDL cholesterol, and total lipids and suicidal thoughts, tendencies, and attempts in both male and female patients with unipolar and bipolar depression [10]. On the other hand, no association with HDL cholesterol was observed in these patients for any suicidal parameter, which was also the case in the present study.…”

Section: Discussionsupporting

confidence: 85%

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Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

Ainiyet¹,

Rybakowski

2014

Med Sci Monit

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BackgroundLifetime suicide mortality in people with schizophrenia is approximately 4–5%, which is higher than in the general population. In mood disorders, many studies and meta-analyses have shown a link between suicidal behavior and low lipid levels, especially that of cholesterol, and some studies have also suggested such a relationship in schizophrenia. Therefore, the aim of the present study was to investigate a possible correlation between suicidal behavior and lipid levels in schizophrenia patients recently admitted to a psychiatric hospital.Material/MethodsOur study included 148 (69 males, 79 females) schizophrenia patients with a mean age of 32±10 years, all recently admitted due to acute exacerbation of their mental illness. Psychometric and laboratory assessments were made within 24–72 hours after hospital admission. The main purpose of the interview was to assess occurrence of any suicidal thoughts, suicidal tendencies, and/or suicide attempts during the 3 months prior to admission. Serum total, LDL and HDL cholesterol, as well as triglycerides and total lipids were measured.ResultsA significant association was found between suicidal thoughts and attempts and low total cholesterol, LDL cholesterol, triglycerides, and total lipids, in both male and female patients. In male patients with suicidal tendencies, correlation with low LDL cholesterol and triglycerides did not reach statistical significance. No association with suicidality was found with HDL cholesterol in subjects studied.ConclusionsThe results obtained suggest that, similar to depressed patients, low total and LDL cholesterol, triglycerides, and total lipids can be state-dependent risk factors for suicidal behavior in Polish patients with schizophrenia.

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Section: Discussionsupporting

confidence: 85%

“…Many subsequent meta-analyses performed in patients with depression demonstrated that, in most studies (including various study designs) a relationship between low serum cholesterol and suicide has been suggested [6–8]. Such a relationship was also observed in a Polish population of depressed patients [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

Ainiyet¹,

Rybakowski

2014

Med Sci Monit

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“…During their follow-up, the TC levels remained low ( 18 ). Moreover, in depression patients suffering from suicidal behavior, LDL-c, TC levels ( 26 ) and triglycerides (TG) levels ( 27 , 28 ) were significantly lower. However, it has been reported that patients with depression who attempt suicide have higher HDL-c levels ( 27 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Zhou

Wang

et al. 2020

Front. Psychiatry

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Several studies have reported a link between lipid disorders and suicidality. However, few studies have investigated the relationship between suicidal behavior and blood lipid profiles in patients with first-episode and drug-naive (FEDN) major depressive disorder (MDD). The main purpose of this study was to examine the relationship between plasma lipid profiles and suicide attempts in a large sample of FEDN MDD patients in the Chinese Han population, which has not been reported. A total of 1,718 MDD outpatients were recruited. Their clinical and demographic data as well as plasma lipid parameters were collected. We obtained suicide attempt data through interviews with patients and their family members. We rated the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) for all patients. The suicide attempt rate of MDD patients was 20.14%, of which 13.68% in the last month and 6.46% in the past. Further, compared with non-attempters, suicide attempters had significantly higher total levels of cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c), higher HAMA and HAMD scores, but significantly lower high-density lipoprotein cholesterol (HDL-c) levels. Logistic regression analysis showed that suicide attempts were correlated with higher TC, lower HDL-c, and higher HAMA and HAMD scores with the adjusted odds ratio (OR) of 1.35, 0.52,1.28, and 1.08, respectively (all p < 0.05). Our findings suggest that FEDN patients with MDD have a high rate of attempted suicide. In the early stage of MDD patients, certain blood lipid parameters and more severe symptoms of anxiety and depression are correlated with suicide attempts. However, due to the cross-sectional design of this study, it is impossible to draw a causal relationship between lipid profiles and suicide attempts. Moreover, an inverse correlation can also be considered, that is, high cholesterol may be the consequence of suicide attempts and depression.

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“…Conversely, some authors revealed a positive association between serum lipid levels and suicide attempt (Brunner et al,2006;Baek et al, 2014). Finally, cross-sectional (Ainiyet et al,2014;Loas et al, 2016) and cohort studies (Fiedorowicz and Coryell, 2007) including depressive subjects among MDD, bipolar and schizoaffective disorder showed different results. Similarly studies including individuals with bipolar (d'Ambrosio et al,2012;Shakeri et al,2014;Ahmadpanah et al,2015), schizoaffective (Marcinko et al,2008) or mixed mood disorders (Kunugi et al,1997;Guillem et al, 2002;da Graca Cantarelli et al,2015) produced controversial results.…”

Section: Observational Studiesmentioning

confidence: 97%

Recent suicide attempts and serum lipid profile in subjects with mental disorders: A cross-sectional study

Capuzzi

Bartoli

Crocamo

et al. 2018

Psychiatry Research

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Background: Subjects with mental disorders have a higher risk of suicide behaviors than the general population. So, to date, researchers have investigated some biomarkers possibly related to suicidality. Despite many studies have reported a possible relationship between low lipid serum levels and suicide attempt, conflicting results have emerged. Aim We investigated whether serum total cholesterol, LDL cholesterol and triglycerides are associated with recent suicide attempts in subjects with different mental disorders. Methods We conducted a cross-sectional study, including 593 consecutively admitted inpatients with schizophrenia spectrum, bipolar, major depressive, and personality disorders. Serum lipid levels were compared between subjects admitted for a recent suicide attempt and those without such recent history. Moreover, according to hypothesis that links impulsivity and violence with low serum lipid levels, the association between lipid levels and violent suicide attempt was assessed. Results We did not find any association of total and LDL cholesterol and triglycerides with suicide attempts, also considering diagnosis and suicide methods. In addition, a post-hoc analysis showed a trend toward significance (p=0.06) in the association between high cholesterol level (≥160mg/dL) and recent suicide attempt. Conclusions Our results do not support the hypothesis of association between lipid profiles and suicide attempts in subjects with different mental disorders. Further research is needed to clarify the role of biomarkers in suicidal behaviors.

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Suicidal behaviour and lipid levels in unipolar and bipolar depression

Cited by 28 publications

References 27 publications

Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

Suicidal Behavior in Schizophrenia may be Related to Low Lipid Levels

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Recent suicide attempts and serum lipid profile in subjects with mental disorders: A cross-sectional study

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