Suicidal Hanging Donors for Lung Transplantation: Is This Chapter Still Closed? Midterm Experience from a Single Centre

Ananiadou, Olga; Zych, Bartłomiej; Sáez, Diana García; Mohite, Prashant N.; Schmack, Bastian; Fazekas, Levente; Husain, Mubassher; Jothidasan, A.; Sabashnikov, Anton; Weymann, Alexander; Reed, Anna; Carby, Martin; Robertis, Fabio De; Simon, A.; Popov, Aron‐Frederik

doi:10.1016/j.healun.2017.01.1525

Cited by 7 publications

(12 citation statements)

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“…Our results differ from the reported series by Ananiadou et al, in which there was a higher incidence of postoperative ECMO support in the HG . These results are probably due to differences in the management of assistance between our two teams, rather than to different perioperative consequences due to pulmonary grafts.…”

Section: Discussioncontrasting

confidence: 99%

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Hanging donor lungs give good short‐, mid‐ and long‐term results in lung transplantation

Wolf

Renard

Lehouerou

et al. 2019

Clinical Transplantation

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Background:Hanging donors are considered as marginal donors and frequently unsuitable for lung transplantation. However, there is no evidence of higher lung transplantation (LTx) morbidity-mortality with lungs providing by hanging donor. Methods:Between January 2010 and July 2015, we performed a retrospective study at Foch hospital. We aimed to assess whether hanging donor grafts are suitable for lung transplantation. Results: A total of 299 LTx were performed. Subjects were allocated to a hanging group (HG) (n = 20) and a control group (CG) (n = 279). Donor and recipient characteristics did not differ. Primary graft dysfunction (PGD) at 72 hours was comparable in both groups (P = .75). The median duration of postoperative mechanical ventilation (1 [range, 0-84] vs 1 [range, 0-410] day, P = .35), the hospital length of stay (31 days [20-84] vs 32 days [12-435], P = .36) did not differ between the two groups. No statistically significant difference was found in 1-year and 5-year survival between the HG (83% and 78%) and the CG (86% and 75%), P = .85. Conclusion: We believe that hanging donors should be considered as conventional donors with particular caution in the final evaluation of the graft and in perioperative management. K E Y W O R D S extended donors, hanging donors, lung transplantation, marginal donors, primary graft dysfunction R E FE R E N C E S

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Section: Discussioncontrasting

confidence: 99%

“…Our results corroborate the experience published recently by Ananiadou . Indeed, over a retrospectively analyzed 4‐year period, the authors concluded that use of suicidal hanging donor lungs did not worsen the postoperative clinical course or mid‐term survival of recipients.…”

Section: Discussionsupporting

confidence: 91%

Hanging donor lungs give good short‐, mid‐ and long‐term results in lung transplantation

Wolf

Renard

Lehouerou

et al. 2019

Clinical Transplantation

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“…15,16 Donation after suicide by hanging did not negatively affect allograft outcomes. 17 Donor drug use did not appear to alter recipient outcomes. 18 Traumatic brain injury did not seem to worsen outcomes with donor lungs.…”

Section: Lung Transplantationmentioning

confidence: 93%

Noteworthy Literature Published in 2018 for Thoracic Organ Transplantation

Tawil

Adams

Nicoara

et al. 2019

Semin Cardiothorac Vasc Anesth

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Publications of note from 2018 are reviewed for the cardiothoracic transplant anesthesiologist. Strategies to expand the availability of donor organs were highlighted, including improved donor management, accumulating experience with increased-risk donors, ex vivo perfusion techniques, and donation after cardiac death. A number of reports examined posttransplant outcomes, including outcomes other than mortality, with new data-driven risk models. Use of extracorporeal support in cardiothoracic transplantation was a prominent theme. Major changes in adult heart allocation criteria were implemented, aiming to improve objectivity and transparency in the listing process. Frailty and prehabilitation emerged as targets of comprehensive perioperative risk mitigation programs.

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“…Death from hanging and other causes of acute airway obstruction are thought to cause post-obstructive barotrauma and negative pressure pulmonary edema that historically made these donors poor candidates for transplantation (40). Several studies, however, demonstrated that in otherwise suitable donors, outcomes from these donors are no different than from conventional donors (40,41). In both studies, these donors represented nearly 10% of all transplants performed at these centers, suggesting wider utilization these donors could have a significant impact on transplant volumes.…”

Section: Cause Of Deathmentioning

confidence: 99%

A narrative review of the impact of donor factors and selection criteria on outcomes after lung transplantation

Peltz¹

2023

Curr Chall Thorac Surg

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Objective: The purpose of this review is to critically evaluate lung donor selection criteria and assess their impact on outcomes after lung transplantation.Background: Lung transplantation remains the most effective therapy for end stage pulmonary disease.Selection of a suitable donor is essential for a successful recipient outcome. Both physiological and physical characteristics of the donor organ factor into decision making for proceeding with a transplant. Donor medical history may also be important when assessing potential offers.Methods: A contemporary literature review of lung donor variables and their impact on outcomes after lung transplantation was performed using Ovid and PubMed search engines. The relative importance of each factor on decision making was evaluated based on the available evidence from identified reference sources.Conclusions: Donor acceptance criteria typically involve acceptable gas exchange, size match, radiographic appearance, bronchoscopic inspection, limited smoking history and finally intraoperative surgical evaluation.Donor age, human leukocyte antigen (HLA) mismatches, serology and comorbidities such as hypertension and diabetes mellitus may be equally if not more important risk factors affecting recipient survival.Additionally, certain recipient variables should be considered when evaluating an organ offer. Donor type, brain dead or donation after determination of circulatory death, does not seem to significantly affect outcomes after lung transplantation.

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Suicidal Hanging Donors for Lung Transplantation: Is This Chapter Still Closed? Midterm Experience from a Single Centre

Cited by 7 publications

References 0 publications

Hanging donor lungs give good short‐, mid‐ and long‐term results in lung transplantation

Hanging donor lungs give good short‐, mid‐ and long‐term results in lung transplantation

Noteworthy Literature Published in 2018 for Thoracic Organ Transplantation

A narrative review of the impact of donor factors and selection criteria on outcomes after lung transplantation

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