2023
DOI: 10.1093/noajnl/vdad058
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Suicidal ideation and attempts in brain tumor patients and survivors: A systematic review

Mohammad Mofatteh,
Mohammad Sadegh Mashayekhi,
Saman Arfaie
et al.

Abstract: Background Subsequent to a diagnosis of a brain tumor, psychological distress has been associated with negative effects on mental health as well as suicidality. The magnitude of such impact has been understudied in the literature. We conducted a systematic review to examine the impact of a brain tumor on suicidality (both ideation and attempts). Methods In accordance with the PRISMA guidelines, we searched for relevant peer-r… Show more

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Cited by 10 publications
(7 citation statements)
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“…However, the average survival duration is still less than 15 months, and the 5-year survival is below 10% [ 6 , 8 , 10 , 11 ]. These patients also have an increased risk of suicide, possibly due to the poor prognosis of this pathology and because of treatment-related side effects, such as mood-altering steroids [ 53 ]. Establishing new treatment regimens based on different peripheral markers that are easy to determine from the patient’s peripheral blood, such as KBs, and introducing adjuvant therapies based on these parameters, such as ketogenic diets, and thus essentially individualizing treatments, may result in an increase in the survival rate.…”
Section: Discussionmentioning
confidence: 99%
“…However, the average survival duration is still less than 15 months, and the 5-year survival is below 10% [ 6 , 8 , 10 , 11 ]. These patients also have an increased risk of suicide, possibly due to the poor prognosis of this pathology and because of treatment-related side effects, such as mood-altering steroids [ 53 ]. Establishing new treatment regimens based on different peripheral markers that are easy to determine from the patient’s peripheral blood, such as KBs, and introducing adjuvant therapies based on these parameters, such as ketogenic diets, and thus essentially individualizing treatments, may result in an increase in the survival rate.…”
Section: Discussionmentioning
confidence: 99%
“…Molecular targeted therapies have emerged as a promising avenue for addressing GBM's complexity and limited treatment options [6][7][8][9][10][11]. Frequent genetic alterations, such as p53 mutations, EGFR amplification, CDKN2a deletion, and PTEN mutations, offer potential therapeutic targets [11][12][13][14][15][16][17][18][19][20][21]. Current treatments, including surgery, radiation, and chemotherapy, yield a median survival of only 15 months for GBM patients, with frequent aggressive recurrences [12].…”
Section: Introductionmentioning
confidence: 99%
“…Current treatments, including surgery, radiation, and chemotherapy, yield a median survival of only 15 months for GBM patients, with frequent aggressive recurrences [12]. Patients also contend with significant psychological challenges that impact their quality of life [14].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the unique property of the brain, protected by the blood-brain barrier (BBB), limits the availability of safe and effective treatment options. The poor prognosis of brain metastasis patients, characterized by high mortality rate and the difficulty of treatment, is speculated to be a significant factor contributing to increased psychological burden on patients and potentially leading to suicidal ideation ( Mofatteh et al, 2023 ). For breast cancer to metastasize to distant tissues such as the brain, circulating tumor cells (CTCs) need to be released from the primary tumor site and adhere to the metastatic site ( Bidard et al, 2016 ; Boral et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%