Suicidal Ideation With IFN-α and Ribavirin in a Patient With Hepatitis C

Ademmer, Karin; Beutel, Manfred E.; Bretzel, Reinhard G.; Clemens, Jens; Reimer, Christian

doi:10.1176/appi.psy.42.4.365

Cited by 40 publications

(23 citation statements)

References 15 publications

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“…An increase in cytokine levels in the blood has been hypothesized as one potential catalyst for the decompensation of depression (27)(28)(29). Cytokine-treated patients may also experience an increase in depressive symptoms, including suicidal ideation and attempted suicide (30)(31)(32)(33). Even a low dose of cytokine-promoting endotoxins such as lipopolysaccharides (LPS), can trigger depressive symptoms along with anxiety without bringing about other sickness behaviors (26).…”

Section: Introductionmentioning

confidence: 99%

“…Certain cytokines released during LPS-induced inflammation are also released during the allergic response. For instance, mast cell degranulation releases TNF-α (34), the administration of which has been shown in animal models to be anxiogenic (33). We have seen that sensitization and subsequent exposure to tree pollen (25) and intranasal LPS administration (35) induce anxiety-like behaviors in sensitized rodents.…”

Section: Introductionmentioning

confidence: 99%

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Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens

Postolache

Zimmerman

Lapidus

et al. 2009

Journal of Allergy and Clinical Immunology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens

Postolache

Zimmerman

Lapidus

et al. 2009

Journal of Allergy and Clinical Immunology

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“…Likewise, suicidal ideation among HCV subjects has been shown to be related to a previous history of psychological disorders and poor coping with life events, rather than anti-HCV therapy (e.g. interferon-α and ribavirin) [25]. …”

Section: Introductionmentioning

confidence: 99%

Emotional Stress, Psychosocial Variables and Coping Associated with Hepatitis C Virus and Human Immunodeficiency Virus Infections in Intravenous Drug Users

Grassi

Satriano²,

Serra³

et al. 2002

Psychother Psychosom

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Background: The increasing health problem of hepatitis C virus (HCV) infection has only recently attracted the attention of psychosocial research, especially among subjects at higher risk (e.g. intravenous drug users; IDUs). The aim of the present study was to compare emotional stress symptoms, psychosocial variables (i.e. social support, external locus of control and emotional repression) and coping strategies in HCV-seropositive, human immunodeficiency virus (HIV)-seropositive and HCV/HIV-noninfected IDUs. Methods: IDUs followed by the Infectious Diseases Outpatient clinic were enrolled in the study over a period of 1 year. HCV-positive (n = 62) and HIV-positive (n = 76) IDUs and HCV/HIV-seronegative IDUs (n = 152) completed the Brief Symptom Inventory, the Social Provision Scale, the Locus of Control scale and the affective inhibition scale of the Illness Behavior Questionnaire. Coping with illness among HCV-positive and HIV-positive subjects was assessed through a modified version of the Mental Adjustment to Cancer Scale. Results: No significant differences were found between the samples with respect to individual and interpersonal variables. HCV-positive subjects showed higher scores on several psychological stress dimensions (i.e. obsessive-compulsive, phobic anxiety, paranoid ideation, psychoticism) and lower scores on fighting spirit, hopelessness and anxious preoccupation towards illness than HIV-positive patients. HCV-positive and HCV/HIV-seronegative IDUs reported comparable scores on most of the psychological measures. Conclusions: The findings indicate that routine assessment of psychosocial variables and coping mechanisms should be integrated into all HCV and HIV services, especially those dedicated to treatment of patients with substance abuse, as a vulnerable segment of the population at risk for life-threatening physical illness such as HCV and HIV infections.

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“…In one case a patient on standard IFN thrice weekly developed symptoms of anxiety, sleep disturbances, guilt feelings, and problems at work culminating in suicidal ideation and urgent hospital admission. 55 Suicidal ideation with delusions and insomnia in a patient on Peg-IFN and ribavirin has also been reported, with symptoms presenting submit your manuscript | www.dovepress.com…”

Section: Suicide Risk and Ifn For Hcv Treatmentmentioning

confidence: 98%

Depression and pegylated interferon-based hepatitis C treatment

Papafragkakis

Rao

Moehlen

et al. 2012

IJICMR

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Abstract:Interferon remains an essential component of treatment regimens for chronic hepatitis C infection. Mood disturbances, including depression, are relatively common in the hepatitis C virus-infected population and may worsen during hepatitis C treatment. Screening for depression prior to commencement of therapy is crucial and may improve treatment outcomes. Whether prophylactic antidepressant therapy should be initiated prior to therapy of hepatitis C virus infection with an interferon-based regimen remains unclear. We review the epidemiology, diagnosis, and management of depression before and during treatment of hepatitis C virus infection with interferon.

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Suicidal Ideation With IFN-α and Ribavirin in a Patient With Hepatitis C

Cited by 40 publications

References 15 publications

Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens

Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens

Emotional Stress, Psychosocial Variables and Coping Associated with Hepatitis C Virus and Human Immunodeficiency Virus Infections in Intravenous Drug Users

Depression and pegylated interferon-based hepatitis C treatment

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