Suicidal Ideations in Major Depressed Subjects: Role of the Temporal Dynamics of Anhedonia

Darquennes, Gil; Wacquier, Benjamin; Loas, Gwenolé; Hein, Matthieu

doi:10.3390/brainsci13071065

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…Consistent with the data currently available in the literature, we confirmed that ID (67.0%) and OSAS (42.0%) are frequent comorbidities for MDD patients [44,45]. Furthermore, in this study, we demonstrated that 58.4% of MDD patients with OSAS presented a comorbid ID, which seems to indicate a more frequent occurrence of insomnia complaints in cases of OSAS for MDD patients than for the other subpopulations currently studied for COMISA [12,13,18].…”

Section: Discussionsupporting

confidence: 91%

Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA

Hein,

Wacquier,

Conenna

et al. 2024

Life

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In this study, the 10-year cardiovascular risk associated with comorbid sleep disorders (insomnia disorder, obstructive sleep apnea syndrome, and COMISA [comorbid insomnia and sleep apnea]) was investigated for patients with major depression. To enable our analysis, 607 patients with major depression were selected from the data register of the Sleep Unit. High 10-year cardiovascular risk was considered present when the Framingham Risk Score was ≥10%. The 10-year cardiovascular risk associated with comorbid sleep disorders has been assessed using logistic regression analyzes. High 10-year cardiovascular risk is significant (40.4%) in patients with major depression. After successive introduction of the different confounders, multivariate logistic regressions showed that for patients with major depression high 10-year cardiovascular risk was significantly associated with COMISA but was not significantly associated with insomnia disorder or obstructive sleep apnea syndrome alone. Thus, these results highlight the existence of a negative synergistic action between insomnia disorder and obstructive sleep apnea syndrome on the 10-year cardiovascular risk in patients with major depression, which demonstrates the importance of researching and treating COMISA to improve the prognosis of this specific population subgroup characterized by higher cardiovascular morbidity and mortality.

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Section: Discussionsupporting

confidence: 91%

Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA

Hein,

Wacquier,

Conenna

et al. 2024

Life

Self Cite

View full text Add to dashboard Cite

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Neural correlates of anhedonia in young adults with subthreshold depression: A graph theory approach for cortical-subcortical structural covariance

Yun,

Choi,

Park

et al. 2024

Journal of Affective Disorders

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The Association between Suicidal Ideation and Subtypes of Comorbid Insomnia Disorder in Apneic Individuals

Hein,

Wacquier,

Conenna

et al. 2024

JCM

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Background/Objectives: Given the existence of higher suicidality in apneic individuals, this study aimed to determine the potential role played by subtypes of the comorbid insomnia disorder (CID) in the occurrence of suicidal ideation for this specific subpopulation. Methods: To perform our analyses, 1488 apneic individuals were retrospectively extracted from the Sleep Laboratory hospitalization register. Only apneic individuals with suicidal ideation highlighted during the psychiatric interview and/or with a score ≥1 on item G of the Beck Depression Inventory confirmed during the clinical interview were included in the group with suicidal ideation. The likelihood of suicidal ideation associated with CID subtypes was investigated using logistic regression analyses. Results: The prevalence of suicidal ideation was 9.3% in our sample of apneic individuals. After hierarchically introducing the significant confounders for adjustment, multivariate logistic regression analyses demonstrated that unlike short sleep duration alone and CID without short sleep duration, the likelihood of suicidal ideation was only higher for CID with short sleep duration in apneic individuals. Conclusions: Thus, we highlighted in this study that CID with short sleep duration could play a major role in higher suicidality for apneic individuals, which seems to require systematic screening and appropriate treatment of this comorbid sleep disorder to enable better management of suicidal risk in this specific subpopulation.

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Suicidal Ideations in Major Depressed Subjects: Role of the Temporal Dynamics of Anhedonia

Cited by 4 publications

References 58 publications

Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA

Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA

Neural correlates of anhedonia in young adults with subthreshold depression: A graph theory approach for cortical-subcortical structural covariance

The Association between Suicidal Ideation and Subtypes of Comorbid Insomnia Disorder in Apneic Individuals

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