Suicidal poisoning with mercaptodimethur–morphological findings and toxicological analysis

Thierauf, Annette; Gnann, Heike; Bohnert, Michael; Vennemann, Benedikt; Auwärter, Volker; Weinmann, Wolfgang

doi:10.1007/s00414-008-0313-8

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Residual amounts of MC have been monitored in the water, soil, honey, plants, fruits and vegetables (Blasco et al, 2005; González-Rodríguez et al, 2008; Huertas-Pérez and García-Campaña, 2008; Picó and Kozmutza, 2007; Pirard et al, 2007; Saraji and Esteki, 2008; Strankowski and Stanley, 1981; Topuz and Alpertunga, 2003; Wilsont and Foos, 2006). Moreover, the first clear report on the fatal poisoning of a human with MC has been reported recently (Thierauf et al, 2009). Despite extensive use of MC, very limited studies on the mechanisms of its action other than the inhibition of acetylcholinesterase activity are currently available.…”

Section: Introductionmentioning

confidence: 99%

Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats

et al. 2012

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Methiocarb (MC) is a widely used carbamate pesticide in agriculture and health programs. Although the main molecular mechanism of carbamate toxicity involves acetylcholinesterase inhibition, studies have also implicated the induction of oxidative stress. Therefore, the present study was aimed to evaluate the effect of acute MC exposure on lipid peroxidation, antioxidant defense systems, histological changes in Wistar rats and the protective effect of pretreatment with vitamin E and taurine. A total of 48 rats were randomly divided into six groups. Rats in group I were given corn oil, while those in group III were dosed with vitamin E (100 mg/kg body weight (b.w.)) and in group V were dosed with taurine (50 mg/kg b.w.). Rats in group II were administered with MC only (25 mg/kg b.w., 1/4 of median lethal dose (LD(50))), while those in groups IV and VI were pretreated with vitamin E (100 mg/kg b.w.) and taurine (50 mg/kg b.w.) for 20 days, respectively, and then exposed to MC (25 mg/kg b.w.). The rats administered with MC showed significant increase in the levels of malondialdehyde in the liver and kidney as an index of lipid peroxidation. Levels of glutathione and activities of superoxide dismutase, catalase and glutathione peroxidase were significantly increased, while activity of glutathione reductase remained unchanged in both the tissues after MC treatment. Mild degenerative histological changes were observed in liver tissue, while the changes in kidney tissue were more severe then liver after MC treatment. Pretreatment with vitamin E and taurine resulted in a significant decrease in the lipid peroxidation and alleviating effects on antioxidant defense systems in both the tissues, while protective effects on the histological changes were shown only in kidney when compared with liver. In conclusion, the study has demonstrated that the acute MC exposure in Wistar rats caused oxidative damage on liver and kidney, which were partly ameliorated by the pretreatment of vitamin E and taurine.

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Section: Introductionmentioning

confidence: 99%

Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats

et al. 2012

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“…In farmers and horticulturists, toxic pesticides may be used for committing suicide by poisoning, which is sometimes indicated by a characteristic smell or warning dye ( [28][29][30], Fig. 2).…”

Section: Occupation-related Suicidementioning

confidence: 99%

Medicolegal evaluation of suicidal deaths exemplified by the situation in Germany

Perdekamp

Pollak

Thierauf

2010

Forensic Sci Med Pathol

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Suicide is a significant form of unnatural death and must be differentiated as such from other violent manners of death (homicide, accident), but also from unexpected deaths due to natural causes. The distinction is made on the basis of a careful collection and correct interpretation of post-mortem forensic findings on the one hand, the general background of the case and the criminal investigation at the scene on the other. For competent assessment by the post-mortem medical examiner and/or forensic pathologist, a thorough knowledge of the numerous methods of committing suicide and their pathomorphological correlates is indispensable. This not only includes the constellation of findings and injury patterns typical of suicide, but also unusual manifestations. Highly conspicuous are complex suicides, in which several methods are applied simultaneously, or one after the other, as well as joint suicides and homicide-suicides involving several persons. Certain settings also deserve special attention. Moreover, simulated or dissimulated suicide is a possibility that must always be borne in mind in forensic practice.

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Toxin- and Drug-Induced Pathologies

Dettmeyer¹

2018

Forensic Histopathology

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Suicidal poisoning with mercaptodimethur–morphological findings and toxicological analysis

Cited by 10 publications

References 9 publications

Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats

Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats

Medicolegal evaluation of suicidal deaths exemplified by the situation in Germany

Toxin- and Drug-Induced Pathologies

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