Suicide and accidental deaths among patients with primary malignant bone tumors

Yu, Kaixu; Wu, Bian; Chen, Ying; Kang, Huifang; Song, Kunpeng; Dong, Ying; Peng, Renpeng; Li, Feng

doi:10.1016/j.jbo.2021.100353

Cited by 8 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, the commonly used treatment of NSCLC in clinical practice is mainly chemotherapy. However, there is still a lack of specific evaluation indicators for evaluating the severity of NSCLC and the efficacy of chemotherapy [11][12][13]. In recent years, PLR, as a biochemical indicator with strong operability, stable results, and low cost, has been favored by researchers.…”

Section: Discussionmentioning

confidence: 99%

Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis

Zhao

Pan

Sheng

et al. 2022

Emergency Medicine International

View full text Add to dashboard Cite

Objective. To investigate the relationship between blood platelet-to-lymphocyte ratio (PLR) and clinicopathological characteristics of patients with advanced non-small cell lung cancer (NSCLC) and evaluate the value of PLR for predicting the efficacy of chemotherapy and prognosis. Methods. The clinical data of 175 patients with advanced NSCLC diagnosed from March 2017 to December 2018 in our hospital were retrospectively analyzed, and the data of 175 healthy subjects from our hospital physical examinations were included. The platelet was detected by using a blood cell analyzer to calculate PLR. According to the average PLR value (197) before chemotherapy, 175 patients were divided into the low PLR group (=78) and the high PLR group (=97). The relationship between the expression levels of PLR and clinicopathologic features was analyzed, and the Kaplan–Meier survival curve was used to analyze the relationship between the expression levels of PLR and prognosis. Results. The results showed that prechemotherapy PLR levels were significantly higher in NSCLC compared with the healthy subjects ( P < 0.05 ). After 4 cycles of chemotherapy, the PLR levels were significantly lower than those during prechemotherapy ( P < 0.05 ). The proportion of TNM (IV) stage cases in the low PLR group was lower than that in the high PLR group ( P < 0.05 ). The total effective rate of the first-line chemotherapy was 46.9% (82/175). The effective rate of IIIb staging was higher than that in IV staging ( P < 0.05 ), and the effective rate of the low PLR group was higher than that in the high PLR group ( P < 0.05 ). Multivariate logistic analysis showed that TNM stage 4 and high PLR level were the independent risk factors for the efficacy of the first-line chemotherapy in patients with advanced NSCLC ( P < 0.05 ), and the high PLR level was an independent risk factor affecting the prognosis of patients with advanced NSCLC. The median overall survival (OS) of patients with the low PLR group was 20.8 months, higher than the 12.0 months of patients with the high PLR group ( P < 0.05 ). Conclusion. PLR might have a certain clinical significance for predicting the TNM staging of NSCLC and can provide important diagnostic and prognostic results for patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis

Zhao

Pan

Sheng

et al. 2022

Emergency Medicine International

View full text Add to dashboard Cite

show abstract

“…Table 4 shows that gender and marital statuses are shared in uencing factors of suicide and accidental death in pancreatic cancer patients. Male with pancreatic cancer had a greater risk of suicide and accidental death than females, while a study of suicide and accidental death among bone tumors patients found a similar difference (Yu et al 2021). However, we think the fundamental reasons for gender variations in the risk of suicide and accidental death are due to undiscovered confoundings factors (such as income, lifestyle, and family structure).…”

Section: Discussionmentioning

confidence: 96%

Analysis of the risk of suicide and accidental death in patients with pancreatic cancer in the past 40 years

Tian

Hou

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18-registry Custom database (1975-2016) to determine the latest risk and risk factors of suicide/accidental death in pancreatic cancer patients. Methods: SEER*Stat was used to get the Standardized Mortality Ratio (SMR) for suicide/accidental death in pancreatic cancer patients. The Adjusted Risk Ratio (ARR) and risk factors for suicide/accidental death in pancreatic cancer patients were achieved by the multivariate Poisson regression model and multivariate Cox regression model.Results: Pancreatic cancer patients diagnosed within three months have the highest SMR of suicide (8.52, 95% Confidence Interval [CI]: 5.71-12.24) and accidental death (2.75, 95% CI: 1.98-3.72); Among the pancreatic cancer patients hadn’t performed surgery, patients classified as ‘Recommended but not performed’ have a higher ARR of suicide(3.35, 95% CI: 2.22-4.87) and accidental death(2.12, 95% CI: 1.53-2.87) than patients classified as ‘Not recommended’, the same trend also showed in the multivariate Cox regression model: The Hazard Ratio (HR) of ‘Recommended but not performed’ patients for suicide(Vs ‘Performed’, 2.68, 95% CI: 1.36-5.30) and accidental death(Vs ‘Performed’, 2.68, 95% CI: 1.36-5.30) higher than ‘Not recommended’ patients.Conclusion: Pancreatic cancer patients have a significantly higher risk of suicide and accidental death than the general population and other cancer patients, especially within three months of diagnosis. In addition, we found in the pancreatic cancer patients who hadn’t performed surgery, those ‘Recommended but not performed’ have a higher risk of suicide and accidental death than those ‘Not recommended’. Therefore, we suggest Department doctors collaborate with oncology psychologists and maintain regular touch with patients who are ‘Recommended but not performed’ and diagnosed within three months.

show abstract

“…This may be explained by the higher degree of depression and demoralization caused by the altered gait, function, stability, strength, and appearance resulting from amputation ( 37 – 39 ). Therefore, clinicians should take some measures including long-lasting follow up and psychological support to lower the risk of death from non-sarcoma diseases such as suicide ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Limb Salvage on Prognosis of Patients Diagnosed With Extremity Bone and Soft Tissue Sarcomas

Chen

Song

et al. 2022

Front. Oncol.

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough clinicians and patients with extremity bone and soft tissue (EBST) are increasingly interested in limb salvage surgery (LSS), because of the minimal damage to physical appearance and function, however, there is still a lack of large-scale population studies on whether LSS improves the prognosis of patients.PurposeThe aim of this study was to compare the survival of patients with EBST sarcomas after receiving LSS and amputation.MethodsTo conduct the population-based study, we identified 6,717 patients with a histologically diagnosed bone sarcoma and 24,378 patients with a histologically diagnosed soft tissue sarcoma from the Surveillance, Epidemiology, and End Results database. We analyzed overall survival (OS), cancer-specific survival (CSS), and non-sarcoma survival (NSS) using the Kaplan–Meier method, log-rank test or Gray test, Cox regression model, propensity score-matched analysis, and landmark analysis.ResultsLSS could improve the prognosis in patients with most EBST subtypes, except for Ewing sarcomas and MPNST. However, in the subgroup without distant metastases, limb salvage increased CSS only for patients with osteosarcoma, Ewing sarcoma, and leiomyosarcoma, as well as NSS for patients with chondrosarcoma and synovial sarcoma. Landmark analysis further demonstrated that sarcoma survivors surviving <10 years could benefit from LSS but not for long-term survivors ≥10 years. Moreover, for patients with distant metastases, LSS could improve survival of osteosarcoma patients but worsen CSS among patients with MPNST. Landmark analysis further demonstrated that LSS improved survival among osteosarcomas patients with distant metastases only within 1 year after surgery. Moreover, patients receiving LSS and those receiving amputation had a high risk of dying from different non-sarcoma diseases during the postoperative follow-up.ConclusionsThe impact of limb salvage on the prognosis of patients depends on the pathological subtype and stage of EBST sarcomas.

show abstract

Suicide and accidental deaths among patients with primary malignant bone tumors

Cited by 8 publications

References 36 publications

Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis

Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis

Analysis of the risk of suicide and accidental death in patients with pancreatic cancer in the past 40 years

Impact of Limb Salvage on Prognosis of Patients Diagnosed With Extremity Bone and Soft Tissue Sarcomas

Contact Info

Product

Resources

About