Suicide Attempt by Ingestion of Rotenone-Containing Plant Extracts in French Polynesia: A Case Report

Torrents, Romain; Domangé, B.; Schmitt, C.; Boulaméry, Audrey; Haro, Luc de; Simón, Nicolás

doi:10.1016/j.wem.2017.03.017

Cited by 5 publications

(11 citation statements)

References 5 publications

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“…Of 18 acute poisonings, two occurred in European countries [ 8 , 23 ], 15 happened in Asian and Pacific Island nations [ [1] , [2] , [3] , [4] , 7 , 17 , 18 , 24 ], and one was in South America [ 6 ]. Only one case came from a country where English is the main language [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…In 13 cases (72%), exposure was accidental through food while in five cases (28%) rotenone was ingested with suicidal intentions. The amount of rotenone ingested varied from 0.06 g to 3.12 g. Nine victims (50%) were exposed to rotenone at home [ 1 , 4 , [6] , [7] , [8] , 17 , 23 , 24 ], and three (17%) were at work [ 18 ], with the location of exposure unclear for the remaining six (33%) victims, but most likely in private quarters [ 2 , 3 ].…”

Section: Resultsmentioning

confidence: 99%

“…The most common symptom was vomiting, observed in eleven patients (61%) [ 1 , 2 , 4 , 6 , 8 , 23 , 24 ]. Five patients presented with respiratory depression [ 3 , 6 , 8 , 18 , 24 ], and two likely had respiratory depression based on having received mechanical ventilation [ 1 , 7 ]. Among these seven patients (39%), four vomited before presenting with respiratory depression [ 1 , 6 , 8 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…pachycarpa is wholly poisonous and accidental poisoning has occurred after eating its fruits, which can be misidentified as other edible fruits, such as tamarind [ 5 ]. On the other hand, intentional ingestion of mixtures made from plants known to contain rotenone, such as “nivrée” vines and D. trifoliata leaves, to facilitate suicide has been reported [ 6 , 7 ]. Thus, food-borne poisoning can occur intentionally or mistakenly by ingesting rotenone-containing plant or plant parts.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute rotenone poisoning: A scoping review

Tat,

Heskett,

Boss

2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute rotenone poisoning: A scoping review

Tat,

Heskett,

Boss

2024

Heliyon

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“…Generally, plant phytotoxins belong to the Leguminosae family, including chickpea, lentils, beans, and peas, which are protease inhibitor compounds. However, the Solanaceae plants can produce glycoalkaloid compounds, and cyanogenic glycosides cna be considered the main phytotoxins generated by the Rosaceae plants family [32]. These toxins may only have a repulsive role, or they may possess a range of toxicities to different organisms.…”

Section: Identification and Classification Of Toxinsmentioning

confidence: 99%

Assessment of Phytotoxins Using Different Technologies

Mehdizadeh

Mushtaq

Siddiqui

et al. 2021

Curr. Appl. Sci. Technol.

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Nowadays, phytotoxins as natural compounds extracted from different plants are widely used as growth regulators or growth inhibitors for other plants or microorganisms. Furthermore, phytotoxin study may lead to the synthesis of new products with various biological activities. Therefore, the detection and identification of these compounds is very important in the study of their effects on living organisms and the environment. Different methods have been used for the identification and characterization of phytotoxins. This study is devoted to reviewing various methods for the extraction, purification, detection, and identification of phytotoxins from different plant species. The most common methods for detecting plant toxins include a variety of bioassays (plant, cell, and enzyme assay) and the application of a wide range of chemical and analytical methods (especially chromatographic techniques). Both types of methods will be discussed in more details. Moreover, applications of these methods in the study of phytotoxin interaction from recent studies are exemplified to aid understanding f these interactions. It can be concluded that bioassay and analytical methods are the two fundamental techniques for phytotoxin analysis. In addition, new advanced techniques that can enable better understanding of phytotoxins and their functions and which are based on biochemistry, robotics, biosensors, nanotechnology, and enzyme-based methods will be developed in the near future.

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Biogenic zinc-oxide nanoparticles of Moringa oleifera leaves abrogates rotenone induced neuroendocrine toxicity by regulation of oxidative stress and acetylcholinesterase activity

Akintunde

Farai

Arogundade

et al. 2021

Biochemistry and Biophysics Reports

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Zinc oxide nanoparticles (ZnONPs) from plant origin were postulated to regulate complex hormonal control through the hypothalamus– pituitary–testicular axis and somatic cells due to their unique small size and effective drug delivery to target tissues. This study therefore investigates the biogenic synthesis of zinc oxide nanoparticles (ZnO NPs) from Moringa oleifera leaves on key endocrine hormones (LH, FSH and testosterone), MDA level, antioxidant enzymes (SOD and CAT), acetylcholineesterase (AChE) activity and reactive nitrogen species (NO • ) level in rotenone induced male rat. The animals were divided into six groups (n = 8). Group I was orally given olive oil as vehicle; Group II received 60 mg/kg of rotenone (RTNE) only; Group III (RTNE + ZnONPs) received 60 mg/kg RTNE + 10 mg/kg ZnONPs; Group IV (RTNE + ZnCAP) received 60 mg/kg RTNE + 50 mg/kg zinc capsule; Group V (ZnONPs only) received 10 mg/kg ZnONPs only. Group VI received 50 mg/kg ZnCAP only. The experiment lasted 10 days. TEM and XRD images revealed ZnO NPs. Moreover, the presence of organic molecules in bio-reduction reactions from the FTIR spectrum showed the stabilization of the nanoparticles. Also, animals induced with rotenone exhibited impairment in the leydig cells by depleting LH, FSH, and testosterone levels with reduced AChE activity and significant (p < 0.05) alteration in cerebral enzymatic antioxidants. There was also brain increase in NO • production: marker of pro-inflammation. Nanotherapeutically, ZnONPs regulated hypothalamus–pituitary–testicular axis via modulation of cerebral NO • , FSH, LH, testosterone and AChE activity with induction of anti-oxidative enzymes.

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Suicide Attempt by Ingestion of Rotenone-Containing Plant Extracts in French Polynesia: A Case Report

Cited by 5 publications

References 5 publications

Acute rotenone poisoning: A scoping review

Acute rotenone poisoning: A scoping review

Assessment of Phytotoxins Using Different Technologies

Biogenic zinc-oxide nanoparticles of Moringa oleifera leaves abrogates rotenone induced neuroendocrine toxicity by regulation of oxidative stress and acetylcholinesterase activity

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