Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients

Calandre, Elena P.; Vilchez, J.S.; Molina-Barea, Rocío; Tovar, Maria Isabel; García‐Leiva, Juan M.; Hidalgo, Javier; Rodriguez-Lopez, C.M.; Rico‐Villademoros, Fernando

doi:10.1093/rheumatology/ker203

Cited by 54 publications

(60 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are consistent with previous studies that showed that pain was an independent risk factor for suicide and high comorbidity with depression, in population-based studies,2526 and clinical studies on patients with cancer,27 migraine,28 and fibromyalgia 29. However, few previous studies have focused on the pain of clinical MDD patients.…”

Section: Discussionsupporting

confidence: 92%

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

Jeon

Woo

Kim

et al. 2016

Psychiatry Investig

View full text Add to dashboard Cite

ObjectiveAlthough somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear.MethodsA total of 811 MDD outpatients of aged between 18 to 64 years were enrolled nationwide in Korea with the suicidality module of the Mini-International Neuropsychiatric Interview (MINI) and the Depression and Somatic Symptom Scale (DSSS).ResultsOn stepwise regression analysis, current suicidality scores were most strongly associated with chest pain in men, and neck or shoulder pain in women. Severe chest pain was associated with higher current suicidality scores in men than in women, whereas severe neck or shoulder pain showed no significant differences between the genders. In conclusion, MDD patients of both sexes with suicidal ideation showed significantly more frequent and severe somatic symptoms than those without. Current suicidal risk was associated with chest pain in men, and neck or shoulder pain in women.ConclusionWe suggest that clinicians pay attention to patients' somatic symptoms in real world practice.

show abstract

Section: Discussionsupporting

confidence: 92%

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

Jeon

Woo

Kim

et al. 2016

Psychiatry Investig

View full text Add to dashboard Cite

show abstract

“…The most comprehensive of the epidemiological studies, the University of Michigan National Comorbidity Survey – Replication (Edwards et al, 2006; Ilgen et al, 2008; Tang and Crane, 2006), accordingly reported an almost three-fold increased risk for suicidal attempts (for all types of pain) in a non-clinical sample after controlling for psychiatric/medical comorbidity and for demographic variables. The greatest increase (6.5 fold) was observed in the context of severe headaches followed by non-arthritic chronic pain (6.2 fold); in other studies back pain heightened the risk for completed suicide nine times (Penttinen, 1995) and generalized pain conditions as fibromyalgia and irritable bowel syndrome increased the risk up to 4 fold (Calandre et al, 2011; Spiegel et al, 2007). These figures likely underestimate the problem because about 20% of deaths (Carr et al, 2004; Bohnert et al, 2013) are misclassified as accidental overdoses by pain killers or by other unintentional causes (Cheatle, 2011; Rockett et al, 2010).…”

Section: Introductionmentioning

confidence: 81%

Pain and suicidality: Insights from reward and addiction neuroscience

Elman

Borsook

Volkow

2013

Progress in Neurobiology

184

147

View full text Add to dashboard Cite

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this link remains unclear, it may be potentially related to the partial congruence of physical and emotional pain systems. The latter system’s role in suicide is also conspicuous during setbacks and losses sustained in the context of social attachments. Here we propose a model based on the neural pathways mediating reward and anti-reward (i.e., allostatic adjustment to recurrent activation of the reward circuitry); both are relevant etiologic factors in pain, suicide and social attachments. A comprehensive literature search on neurobiology of pain and suicidality was performed. The collected articles were critically reviewed and relevant data were extracted and summarized within four key areas: (1) physical and emotional pain, (2) emotional pain and social attachments, (3) pain-and suicide-related alterations of the reward and anti-reward circuits as compared to addiction, which is the premier probe for dysfunction of these circuits and (4) mechanistically informed treatments of co-occurring pain and suicidality. Pain-, stress- and analgesic drugs-induced opponent and proponent states of the mesolimbic dopaminergic pathways may render reward and anti-reward systems vulnerable to sensitization, cross-sensitization and aberrant learning of contents and contexts associated with suicidal acts and behaviors. These findings suggest that pain patients exhibit alterations in the brain circuits mediating reward (depressed function) and anti-reward (sensitized function) that may affect their proclivity for suicide and support pain and suicidality classification among other “reward deficiency syndromes” and a new proposal for “enhanced anti-reward syndromes”. We suggest that interventions aimed at restoring the balance between the reward and anti-reward networks in patients with chronic pain may help decreasing their suicide risk.

show abstract

“…In the general population, suicide is the third leading cause of death in people <30 years old 24. Increased risk of suicide has been found in chronic fatigue syndrome25,26 and fibromyalgia 27–30. To our knowledge, no studies of suicide and its relationship to sleep disturbances exist for POTS.…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbance linked to suicidal ideation in postural orthostatic tachycardia syndrome

Pederson

Brook

2017

NSS

View full text Add to dashboard Cite

ObjectiveWe investigated the prevalence of suicidal ideation in relationship with symptoms of sleep disruption in people with postural orthostatic tachycardia syndrome (POTS).MethodsOnline surveys (including the Pittsburgh Sleep Quality Index and the Suicide Behaviors Questionnaire – Revised) were completed by 705 POTS patients and 170 non-POTS controls.ResultsPoor sleep quality was reported in 98.4% of POTS patients with a calculated subjective sleep efficiency of 65.4%. The POTS group’s sleep efficiency was significantly lower (t[873]= −11.32; p<0.001) and sleep disturbances because of pain were significantly higher (t[873]=15.36; p<0.001) than controls. Chi-square testing showed a larger proportion of individuals at high-risk for suicide among POTS patients than controls (c2 [1, n=875]=55.6; p<0.001). Multiple linear regression analysis showed that sleep scores (β=0.23, p<0.001), age (β=–0.03, p<0.001), and illness with POTS (β=0.68, p=0.05) were significantly associated with suicide ideation scores (F[4, 870]=38.34, p<0.001). This model explained 15% of variance (R2=0.15) in suicidal ideation scores.ConclusionPatients with POTS may suffer from increased sleep disturbance and suicidal ideation compared with the general population. Treatment to improve sleep efficiency and sleep quality is an important step toward better quality of life for POTS patients.

show abstract

Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients

Abstract: FM is associated with an increased risk of suicide and suicide attempts. Suicidal behaviour seems to be related with the global severity of the disease.

Cited by 54 publications

References 15 publications

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

Pain and suicidality: Insights from reward and addiction neuroscience

Sleep disturbance linked to suicidal ideation in postural orthostatic tachycardia syndrome

Contact Info

Product

Resources

About