2013
DOI: 10.4172/2157-7412.1000187
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Suicide Gene Therapy against Cancer

Abstract: A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of the most innovative approaches to developing antineoplastic agents with increased tumor selectivity is the use of suicide gene therapy. Suicide gene therapy involves delivering a gene product in proximity to the targeted cancer tissue through various targeted delivery methods followed by tissue/tumor-specific expressi… Show more

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Cited by 3 publications
(9 citation statements)
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“…The term of gene directed enzyme prodrug therapy (GDEPT) is one of the promising alternatives to conventional chemotherapy because it minimizes the systemic toxicities of conventional chemotherapy drugs and refer to expression of a suicide gene in tumor cells for the in situ conversion of a pro‐drug into cytotoxic metabolites (Greco & Dachs, ; Springer & Niculescu‐Duvaz, ). The first attempt to use of suicide genes against cancer was in 1986 by Moolten et al (Rajab et al, ). These points must consider in selection of suicide genes; Intended gene must encodes an enzyme that did not exist in normal cells or there is no enzyme with similar function in cells; Minimal toxicity of prodrug before activation in body and maximum toxicity after converting to active drug in tumor location; high kinetic enzyme activity or high affinity to target prodrug and finally active drug must diffuse in whole tumor mass by Bystander effects (Both, ; Rajab et al, ; Zarogoulidis et al, ).…”
Section: Suicide Genes As a Good Killermentioning
confidence: 99%
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“…The term of gene directed enzyme prodrug therapy (GDEPT) is one of the promising alternatives to conventional chemotherapy because it minimizes the systemic toxicities of conventional chemotherapy drugs and refer to expression of a suicide gene in tumor cells for the in situ conversion of a pro‐drug into cytotoxic metabolites (Greco & Dachs, ; Springer & Niculescu‐Duvaz, ). The first attempt to use of suicide genes against cancer was in 1986 by Moolten et al (Rajab et al, ). These points must consider in selection of suicide genes; Intended gene must encodes an enzyme that did not exist in normal cells or there is no enzyme with similar function in cells; Minimal toxicity of prodrug before activation in body and maximum toxicity after converting to active drug in tumor location; high kinetic enzyme activity or high affinity to target prodrug and finally active drug must diffuse in whole tumor mass by Bystander effects (Both, ; Rajab et al, ; Zarogoulidis et al, ).…”
Section: Suicide Genes As a Good Killermentioning
confidence: 99%
“…The first attempt to use of suicide genes against cancer was in 1986 by Moolten et al (Rajab et al, ). These points must consider in selection of suicide genes; Intended gene must encodes an enzyme that did not exist in normal cells or there is no enzyme with similar function in cells; Minimal toxicity of prodrug before activation in body and maximum toxicity after converting to active drug in tumor location; high kinetic enzyme activity or high affinity to target prodrug and finally active drug must diffuse in whole tumor mass by Bystander effects (Both, ; Rajab et al, ; Zarogoulidis et al, ). This mentions to the demolition of tumor cells that are not directly expressing the suicide gene.…”
Section: Suicide Genes As a Good Killermentioning
confidence: 99%
See 3 more Smart Citations