Suicide risk and alcohol and drug abuse in outpatients with HIV infection and Chagas disease

Guimarães, P. M.; Passos, Sônia Regina Lambert; Calvet, Guilherme Amaral; Hökerberg, Yara Hahr Marques; Lessa, José Luiz Martins; Andrade, Carlos Augusto Ferreira de

doi:10.1590/1516-4446-2013-1219

Cited by 18 publications

(16 citation statements)

References 26 publications

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“…This may be due to the fact that feeling of stigmatized might contribute frequent psychological stress and finally lead to suicidal attempt. This is in agreement with other studies [ 17 ].…”

Section: Discussionsupporting

confidence: 94%

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Suicidal Ideation, Attempt, and Determining Factors among HIV/AIDS Patients, Ethiopia

Bitew

Andargie

Tadesse³

et al. 2016

Depression Research and Treatment

135

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Background. Suicide is a serious cause of mortality worldwide and is considered as a psychiatric emergency. Suicide is more frequent in peoples living with HIV/AIDS than in general population. Objective. To assess the proportion and determining factors of suicidal ideation and attempt among peoples living with HIV/AIDS in Ethiopia. Methods. Institutional based cross-sectional study was conducted from May to June 2015 by selecting 393 participants using systematic random sampling technique. Suicide manual of Composite International Diagnostic Interview (CIDI) was used to collect data. Logistic regression was carried out and odds ratio with 95% confidence intervals was computed. Results. The proportion of suicidal ideation and attempt was 33.6% and 20.1%, respectively. Female sex (AOR = 2.6, 95%CI: 1.27–5.22), marital status (AOR = 13.5, 95%CI: 4.69–39.13), depression (AOR = 17.0, 95%CI: 8.76–33.26), CD4 level (AOR = 2.57, 95%CI: 1.34–4.90), and presence of opportunistic infection (AOR = 5.23, 95%CI: 2.51–10.88) were associated with suicidal ideation, whereas marital status (AOR = 8.44, 95%CI: 3.117–22.84), perceived HIV stigma (AOR = 2.9, 95%CI: 1.45–5.99), opportunistic infection (AOR = 2.37, 95%CI: 1.18–4.76), and poor social support (AOR = 2.9, 95%CI: 1.58–5.41) were significantly associated with suicidal attempt. Conclusion. Suicidal ideation and attempt were high among HIV positive patients. Therefore early screening, treatment, and referral of suicidal patients are necessary in HIV clinics.

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Section: Discussionsupporting

confidence: 94%

“…Females are 2.3 times more likely to have suicidal ideation than male patients. This is supported by previous studies where ideation is higher in females where completed suicide is higher among males [ 12 , 14 , 17 ]. Marital status was also found to be significantly associated with suicidal ideation.…”

Section: Discussionsupporting

confidence: 88%

Suicidal Ideation, Attempt, and Determining Factors among HIV/AIDS Patients, Ethiopia

Bitew

Andargie

Tadesse³

et al. 2016

Depression Research and Treatment

135

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“…In addition, a point worth noting is that all the injury related deaths were suicides, indicating that the psychological factors of HIV-infection should be noticed (Guimarães et al 2014). Understanding causes of death in HIV-infected patients could provide information about the severity of HIV infection, and lead to improvement of the clinical management of people living with HIV/AIDS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Pang

Shang

et al. 2018

Tohoku J. Exp. Med.

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Opportunistic infections (OIs) are the most significant complication of human immunodeficiency virus (HIV) infection. The prevalence of OIs differs among various countries in part due to different climates and socio-economic conditions. We, therefore, carried out the retrospective study at the Public Health Clinical Center of Chengdu, Sichuan to comprehensively investigate the prevalence of OIs, predictors of OIs, and risk factors for in-hospital death among HIV-infected patients. Sichuan in West China is characterized by the largest population living with HIV/Acquired immunodeficiency syndrome (AIDS) across China. In total, we reviewed 954 cases of HIV infection, admitted to the hospital during January 2014 to December 2015, and found that bacterial pneumonia (25.8%) was the most common OIs, followed by candida infection (18.3%), Pneumocystis jiroveci pneumonia (11.9%), tuberculosis (11.5%), infectious diarrhoea (9.3%), cryptococcus infection (7.3%), cytomegalovirus infection (4.9%), toxoplasmosis (4.6%), hepatitis C (4.0%), nontuberculous mycobacteria desease (2.2%) and Penicillium marneffei infection (0.3%). We also found two strongest risk factors for in-hospital mortality: CD4+T cell counts of less than 100 cells/μL and not receiving antiretroviral therapy. Moreover, the study revealed the specific pathogens causing bacterial pneumonia and/or candida infection, the effect of tuberculosis on CD4+T cell counts, and the drug resistance of Mycobacterium tuberculosis among HIV-infected and non-HIV-infected patients. The present findings may aid in the clinical diagnosis and treatment of HIV-infected patients, and could help developing efficient public health strategies in China.

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“…Patients with the symptomatic form of Chagas disease have more psychological and physical symptoms of stress and anxiety, and lower capacity of resilience compared with asymptomatic individuals ( Mota et al 2006 ). Considering the chronic nature of Chagas disease, in persistence of stress the patients may develop depressive symptoms which may have a negative impact on functional performance and quality of life ( Hueb & Loureiro 2005 , Ozaki et al 2011 , Guimarães et al 2014 ).…”

mentioning

confidence: 99%

Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease

Vilar-Pereira

Ruivo

Lannes‐Vieira

2015

Mem. Inst. Oswaldo Cruz

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The existence of the nervous form of Chagas disease is a matter of discussion since Carlos Chagas described neurological disorders, learning and behavioural alterations in Trypanosoma cruzi-infected individuals. In most patients, the clinical manifestations of the acute phase, including neurological abnormalities, resolve spontaneously without apparent consequence in the chronic phase of infection. However, chronic Chagas disease patients have behavioural changes such as psychomotor alterations, attention and memory deficits, and depression. In the present study, we tested whether or not behavioural alterations are reproducible in experimental models. We show that C57BL/6 mice chronically infected with the Colombian strain of T. cruzi (150 days post-infection) exhibit behavioural changes as (i) depression in the tail suspension and forced swim tests, (ii) anxiety analysed by elevated plus maze and open field test sand and (iii) motor coordination in the rotarod test. These alterations are neither associated with neuromuscular disorders assessed by the grip strength test nor with sickness behaviour analysed by temperature variation sand weight loss. Therefore, chronically T. cruzi-infected mice replicate behavioural alterations (depression and anxiety) detected in Chagas disease patients opening an opportunity to study the interconnection and the physiopathology of these two biological processes in an infectious scenario.

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Suicide risk and alcohol and drug abuse in outpatients with HIV infection and Chagas disease

Cited by 18 publications

References 26 publications

Suicidal Ideation, Attempt, and Determining Factors among HIV/AIDS Patients, Ethiopia

Suicidal Ideation, Attempt, and Determining Factors among HIV/AIDS Patients, Ethiopia

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease

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