Suitability of Bronchoscopic Spraying for Fluid Deposition in Lower Airway Regions: Fluorescence Analysis on a Transparent <i>In Vitro</i> Airway Model

Gürzing, Stefanie; Thiebes, Anja Lena; Cornelissen, Christian; Jockenhoevel, Stefan; Reddemann, Manuel Armin

doi:10.1089/jamp.2022.0016

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…To avoid deposition in the upper airway and healthy tissues with no therapeutic effect, an alternative method is to use an endotracheal catheter injection, which involves directly releasing the medication from the trachea into the small airways [ 19 ]. Endotracheal catheters are typically made of medical grade materials such as polyvinyl chloride (PVC), silicone, or Teflon.…”

Section: Introductionmentioning

confidence: 99%

Achieving Targeted Delivery of Chemotherapeutic Particles to Small Airway Tumors via Pulmonary Route Using Endotracheal Catheters: A CFPD Study

Islam

Feng

2023

Pharmaceuticals

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Tracheobronchial tumors, while uncommon, are often malignant in adults. Surgical removal is the primary therapy for non-metastatic lung malignancies, but it is only possible in a small percentage of non-small-cell lung cancer patients and is limited by the number and location of tumors, as well as the patient’s overall health. This study proposes an alternative treatment: administering aerosolized chemotherapeutic particles via the pulmonary route using endotracheal catheters to target lung tumors. To improve delivery efficiency to the lesion, it is essential to understand local drug deposition and particle transport dynamics. This study uses an experimentally validated computational fluid particle dynamics (CFPD) model to simulate the transport and deposition of inhaled chemotherapeutic particles in a 3-dimensional tracheobronchial tree with 10 generations (G). Based on the particle release maps, targeted drug delivery strategies are proposed to enhance particle deposition at two lung tumor sites in G10. Results indicate that controlled drug release can improve particle delivery efficiencies at both targeted regions. The use of endotracheal catheters significantly affects particle delivery efficiencies in targeted tumors. The parametric analysis shows that using smaller catheters can deliver more than 74% of particles to targeted tumor sites, depending on the location of the tumor and the catheter diameter used, compared to less than 1% using conventional particle administration methods. Furthermore, the results indicate that particle release time has a significant impact on particle deposition under the same inhalation profile. This study serves as a first step in understanding the impact of catheter diameter on localized endotracheal injection for targeting tumors in small lung airways.

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Section: Introductionmentioning

confidence: 99%

Achieving Targeted Delivery of Chemotherapeutic Particles to Small Airway Tumors via Pulmonary Route Using Endotracheal Catheters: A CFPD Study

Islam

Feng

2023

Pharmaceuticals

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Targeted delivery of inhalable drug particles in the tracheobronchial tree model of a pediatric patient with bronchopneumonia: A numerical study

Wang

Zhang

Chen

et al. 2023

Respiratory Physiology & Neurobiology

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A novel experimental approach to measure nebulized droplet deposition pattern and deposition fraction in an idealized mouth-to-throat model

Jin,

Chen,

Feng

et al. 2023

Physics of Fluids

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Accurate measurement of droplet/particle deposition fraction and spatial distribution is vital for understanding various inhalation processes, including nebulized therapy, inhalation of atmospheric pollutants, and exposure risk assessment to aerosols such as airborne SARS-COV-2-laden droplets. This paper presents a novel method to measure the deposition fraction and spatial distribution of the deposited particulate phase (i.e., deposition pattern) of droplets through a single experiment. The experiment employs an idealized mouth-to-throat model as a test platform for two vibrating mesh nebulizers to deposit droplets. By utilizing a nebulized solution of normal saline containing the fluorescein, the qualitative observation of droplet deposition pattern on the internal surfaces is achieved under ultraviolet excitation. Furthermore, through rinsing the experimental components and quantitatively determining the deposition fraction based on rinsate absorbance, experimental results indicate that the deposition fraction of nebulized droplets decreases initially and then increases with increasing inspiratory flow rate from 15 to 60 l/min. Additionally, the deposition hotspots gradually shift from the bottom of the oral cavity to the throat as the inhalation flow rate increases. In addition to providing validation data for the transport and deposition of high-concentration droplets, this experimental method has the potential for extension to research on aerosol transmission and exposure risk assessment. It offers valuable insight into the behavior of nebulized droplets, aiding in developing effective strategies for aerosolized therapies and mitigating transmission risks in various applications.

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Suitability of Bronchoscopic Spraying for Fluid Deposition in Lower Airway Regions: Fluorescence Analysis on a Transparent In Vitro Airway Model

Cited by 3 publications

References 18 publications

Achieving Targeted Delivery of Chemotherapeutic Particles to Small Airway Tumors via Pulmonary Route Using Endotracheal Catheters: A CFPD Study

Achieving Targeted Delivery of Chemotherapeutic Particles to Small Airway Tumors via Pulmonary Route Using Endotracheal Catheters: A CFPD Study

Targeted delivery of inhalable drug particles in the tracheobronchial tree model of a pediatric patient with bronchopneumonia: A numerical study

A novel experimental approach to measure nebulized droplet deposition pattern and deposition fraction in an idealized mouth-to-throat model

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