The knowledge of the maximum water depths associated with dam-break fl oods is crucial for the population early warning and evacuation plan design, minimizing the losses due to dam failures. This paper presents an experimental dam-break fl ood propagation study performed in a physical model and a two-dimensional numerical model suitable to simulate fl ow propagation on complex topography. First, the numerical model and the physical model of the River Arade valley, located in the south of Portugal (Algarve), are described. A comparison between computed results and measured data is undertaken and uncertainty in the numerical model predictions is analysed. In this paper, a physical model representing a real river valley stretch is used to validate a dam-break fl ood numerical model and to get information related to uncertainties in what concerns the prediction of the hazard (fl ood) propagation simulation. In fact, for such rare events as dam-break fl oods, the comparison between the results obtained in a physical model and by a numerical model is one of the best sources of uncertainty characterization.The physical model represents a reach of the River Arade valley, located in the south of Portugal. Experimental results refer to water depths measured during tests realized for both steady and unsteady fl ow regimes. The numerical model was developed for the simulation of two-dimensional dam-break fl ood waves in irregular topography valleys where the one-dimensional approach loses validity, such as in fl ood plains and where strong variation of the cross section or alignment occurs. It is based on a total variation diminishing (TVD) extension of the two-dimensional MacCormack method and in a scheme to ensure the capacity to simulate fl ows in domains with general irregular topography.