2021
DOI: 10.28991/scimedj-2021-0304-2
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Suitability System of Microbiological Method for Nystatin Potency Determination in the Routine Analysis Using Agar Diffusion Method

Abstract: Nystatin is a polyene macrolide antifungal active which is used for the treatment of candidiasis and obtained from some species of Streptomycesbacteria. The present work describes the statistical suitability analysis for regular monitoring of the agar diffusion bioassay in a simple, inexpensive and time-saving process before potency determination. A balanced (symmetrical) two-dose parallel line assay model was applied using the agar well diffusion method for quantification of Nystatin in raw material and finis… Show more

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Cited by 4 publications
(7 citation statements)
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“…The sunflower/oil-FA-CSNPs bionanocomposite film exhibited strongest antibacterial potential was subjected to measure bacteriostatic (MIC) and bactericidal (MBC) effects using the agar diffusion method [ 70 ] against two bacterial strains i . e ., B .…”
Section: Resultsmentioning
confidence: 99%
“…The sunflower/oil-FA-CSNPs bionanocomposite film exhibited strongest antibacterial potential was subjected to measure bacteriostatic (MIC) and bactericidal (MBC) effects using the agar diffusion method [ 70 ] against two bacterial strains i . e ., B .…”
Section: Resultsmentioning
confidence: 99%
“…Certainly, fruit fly being an invertebrate model may not entirely reflect the human kidney. For example, although Baclofen was found to have an inhibition effect on CaOx stone formation in fruit fly MT, it was also reported to have nephrotoxicity in humans [ 60 ]. Hence, the results from fruit fly models still need to be complemented with studies on mammalian models to test the safety and effectiveness before the clinical trials.…”
Section: Application In Drug Developmentmentioning
confidence: 99%
“…Here we draw a workflow chart to reveal a general idea of how to use fruit fly kidney stone models in the novel drugs screening ( Figure 4 ). Both candidate synthetic products base on in vitro screening [ 60 ] or bioinformatics prediction and plants from traditional medicinal experience can be analyzed by fruit fly models. The active compounds of the validated active medicinal plants will be further found out due to screening with the same model.…”
Section: Concluding Remarks and Prospectsmentioning
confidence: 99%
“…As discussed earlier, outliers had an impact on data and their statistical evaluation. However, it should be highlighted that rejection and removal of the aberrant values blindly based solely on the outcome of the test would be a discouraging practice [36]. Each situation of detection and removal of the outlier should be evaluated case-by-case to ensure the avoidance of unintended bias that would lead to the omission of a truly valid result as it could be found in the current case [6,36].…”
Section: Outlier Evaluation In Each Treatment Groupmentioning
confidence: 99%