Suitable analysis of α-amino acids by a direct combination of thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry in conjunction with post-chromatographic fixed-charge derivatization

Esparza, C. A.; Polovkov, N. Yu.; Topolyan, A. P.; Борисов, Р. С.; Заикин, В. Г.

doi:10.1016/j.chroma.2020.461335

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…The latter is very useful to avoid using additional procedures to determine analyte elusion zones. The same derivatization agent was involved in the development of a method for analysis of aminoacids (Esparza et al, 2020). The derivatives of α-aminoacids underwent elimination of carbon dioxide under laser irradiation, but the formed ions produced intense peaks in the registered MALDI mass spectra.…”

Section: Derivatizationmentioning

confidence: 99%

Recent Advances in Combinations of TLC With MALDI and Other Desorption/Ionization Mass-Spectrometry Techniques

2021

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The combination of planar chromatography with desorption/ionization mass-spectrometry (MS) techniques provides chemists with unique tools for fast and simple separation of mixtures followed by the detection of analytes by the most powerful analytical method. Since its introduction in the early 1990s, thin-layer chromatography (TLC)/matrix-assisted mass spectrometry (MALDI) has been used for the analysis of a wide range of analytes, including natural and synthetic organic compounds. Nowadays, new desorption/ionization approaches have been developed and applied in conjunction with planar chromatography competing with MALDI. This review covers recent developments in the combination of TLC with various desorption/ionization MS methods which were made in recent several years.

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Section: Derivatizationmentioning

confidence: 99%