Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

Iwase, Mari; Yamamoto, Takayuki; Nishimura, Koshi; Takahashi, Haruya; Mohri, Shinsuke; Li, Yongjia; Jheng, Huei-Fen; Nomura, Wataru; Takahashi, Nobuyuki; Kim, Chu-Sook; Yu, Rina; Taniguchi, Masahiko; K, Baba; Murakami, Shigeru; Kawada, Teruo; Goto, Tsuyoshi

doi:10.1007/s11745-017-4269-7

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…Dietary intake of DPCs also led to decreases in the mean size of white adipocytes ( Figure 5). One recent study has reported that dietary intake of suksdorfin, which has a structure similar to that of the DPCs used in this study, induces adipogenesis in WAT in obese, diabetic KK-Ay mice [27]. Thus, these results suggested that the dietary intake of DPCs can induce the conversion of hypertrophic into hyperplastic obesity in HFD-fed mice.…”

Section: Discussionsupporting

confidence: 71%

Dihydropyranocoumarins Exerted Anti-Obesity Activity In Vivo and its Activity Was Enhanced by Nanoparticulation with Polylactic-Co-Glycolic Acid

2019

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Dihydropyranocoumarins (DPCs) were isolated from Peucedanum japonicum Thunb as anti-obesity compounds in 3T3-L1 adipocytes assay; however, it is uncertain whether DPC exerts anti-obesity activity in vivo. Therefore, this study evaluated the oral intake of pure DPCs in mice fed a high-fat diet, and also attempted to enhance its activity by nanoparticulation. Increases in body weight gain and fat accumulation in white adipose tissues were significantly suppressed by the dietary intake of DPCs (1.943 mg/mouse/day). DPCs intake also significantly decreased the mean size of adipocytes and upregulated mRNA levels of thermogenesis-related genes. Nanoparticulation of DPCs with polylactic-co-glycolic acid (PLGA) dramatically increased its activity almost 100-fold over that of a non-nanoparticulated form. Thus, our findings clearly demonstrated the anti-obesity activity of DPCs in vivo and suggested that PLGA nanoparticle encapsulation was useful to enhance the anti-obesity activity of DPCs with the aim to develop natural and safe anti-obesity agents.

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Section: Discussionsupporting

confidence: 71%

Dihydropyranocoumarins Exerted Anti-Obesity Activity In Vivo and its Activity Was Enhanced by Nanoparticulation with Polylactic-Co-Glycolic Acid

2019

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“…Regarding the bioactive properties of lovage coumarins, apterin has been previously determined to be a common apiaceous coumarin [ 65 ] and showed antioxidant [ 66 ], anti-tumor [ 67 ], anticholinesterase [ 68 ], antidiabetic [ 69 , 70 ], and anti-inflammatory activities [ 71 ]. Xanthotoxin has demonstrated various bioactivities, such as anticancer, anti-inflammatory, antioxidative stress and antibacterial activities [ 72 ], while pimpinellin was determined to be an effective preventer of platelet-related thromboembolic diseases (such as atherosclerosis [ 73 ]), and isopimpinellin is antibacterial agent against methicillin-resistant Staphylococcus aureus [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage

Оленников

2022

Metabolites

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Lovage (Levisticum officinale W.D.J. Koch) is a known aromatic apiaceous species that is widely used as a culinary and medicinal plant. Traditionally, more scientific attention has been paid to lovage volatiles, while other groups of compounds have been underutilized. In this study, metabolites of fresh lovage roots were investigated by liquid chromatography–mass spectrometry, and 25 compounds were identified, including coumarins as basic components and minor hydroxycinnamates; most were detected for the first time in the plant. Four major coumarins (including apterin, xanthotoxin, isopimpinellin, and pimpinellin) were successfully separated by a validated HPLC–PDA method, and the fresh roots of seven lovage cultivars as well as the dry roots of commercial lovage were quantified. The coumarin content deviation was 1.7–2.9 mg/g in the fresh roots and 15–24 mg/g in the dry roots. A variation in the coumarin level was found during storage of the fresh lovage roots at chill and room temperatures, while storage of the dried roots at room temperature showed the lowest loss of target compounds. This new information about the metabolites of lovage indicates the prospects of the plant roots as a source of dietary coumarins.

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“…PPARα is primarily expressed in the brown adipose tissue and liver, while the expression of PPARγ is abundant in the adipose tissue and works as an important transcription factor in adipocyte differentiation [ 32 ]. Thus, PPARγ agonists have been applied to control insulin resistance induced by obesity [ 33 ]. Moreover, PPARα functions as the physiological stimuli in the fasting state, and it is hypothesized that the free fatty acids transported from adipose tissue to the liver act as ligands and activate PPARα [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity and Hypocholesterolemic Actions of Protamine-Derived Peptide RPR (Arg-Pro-Arg) and Protamine in High-Fat Diet-Induced C57BL/6J Mice

et al. 2021

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Dietary protamine can ameliorate hyperlipidemia; however, the protamine-derived active peptide and its hypolipidemic mechanism of action are unclear. Here, we report the discovery of a novel anti-obesity and hypocholesterolemic peptide, RPR (Arg-Pro-Arg), derived from protamine in mice fed a high-fat diet for 50 days. Serum cholesterol levels were significantly lower in the protamine and RPR groups than in the control group. White adipose tissue weight was significantly decreased in the protamine and RPR groups. The fecal excretion of cholesterol and bile acid was significantly higher in the protamine and RPR groups than in the control group. We also observed a significant decrease in the expression of hepatic SCD1, SREBP1, and adipocyte FAS mRNA, and significantly increased expression of hepatic PPARα and adipocyte PPARγ1 mRNA in the protamine group. These findings demonstrate that the anti-obesity effects of protamine are linked to the upregulation of adipocyte PPARγ1 and hepatic PPARα and the downregulation of hepatic SCD1 via SREBP1 and adipocyte FAS. RPR derived from protamine has a crucial role in the anti-obesity action of protamine by evaluating the effective dose of adipose tissue weight loss.

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Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

Cited by 11 publications

References 26 publications

Dihydropyranocoumarins Exerted Anti-Obesity Activity In Vivo and its Activity Was Enhanced by Nanoparticulation with Polylactic-Co-Glycolic Acid

Dihydropyranocoumarins Exerted Anti-Obesity Activity In Vivo and its Activity Was Enhanced by Nanoparticulation with Polylactic-Co-Glycolic Acid

Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage

Anti-Obesity and Hypocholesterolemic Actions of Protamine-Derived Peptide RPR (Arg-Pro-Arg) and Protamine in High-Fat Diet-Induced C57BL/6J Mice

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