Sulcular Exudate Flow in Gingival Inflammation

Shapiro, Leonard M.; Goldman, Henry M.; Bloom, Arthur A.

doi:10.1902/jop.1979.50.6.301

Cited by 51 publications

(33 citation statements)

References 9 publications

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“…Uttio 16) reported that in periodontitis, increased in GCF volume was associated with increased in probing pocket depth and deeper pockets were associated with higher GCF volume. Finding in the present study supports the suggestion that GCF volume increases with gingival inflammation and periodontitis 14,18,38,39) . In the present study, when GCF volume was compared at healthy gingival sites in all 3 groups, there was significant increase in GCF volume in both gingivitis and periodontitis group compared to healthy gingival group.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Sehdev

Ganji

Bhongade

et al. 2017

J. Hard Tissue Biology.

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Clinical periodontal status is among the major determinants of the volumetric features of GCF. Previous studies have shown that probing depth, presence/severity of gingival and periodontal inflammation affect the biodynamics of GCF. The aim of the present study was to evaluate the impact of the clinical periodontal status on volumetric features of gingival crevicular fluid. Thirty-six patients were equally divided into healthy group, gingivitis group and periodontitis group. Clinical periodontal status was assessed by recording: papillary bleeding index, probing pocket depth and clinical attachment level. Gingival crevicular fluid (GCF) samples were obtained from 4 sites in each patient. The mean volume of GCF was determined in each group for comparison. Further in periodontitis group, GCF samples were also collected from healthy sites, gingivitis sites and periodontitis sites. Mean GCF volume recorded by using Periotron® 8000 in healthy gingival group, gingivitis group and periodontitis group were: 0.04, 0.09, 0.78 µl respectively. There was increase in GCF volume in a diseased related pattern, healthy gingival group < gingivitis group < periodontitis group. In periodontitis group, the sites with healthy gingiva showed significantly higher GCF volume than healthy gingival group (0.11µl Vs 0.04µl), similarly, the sites with gingivitis in periodontitis group also showed significantly higher GCF volume than gingivitis group (0.32µl Vs 0.11µl). The present study suggests that the volumetric analysis of GCF could be sensitive and reliable indicator of periodontal health. The ability of GCF volume as a chair side measure to differentiate healthy sites from sites with mild disease within the same mouth is considered noteworthy.

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Section: Discussionsupporting

confidence: 92%

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Sehdev

Ganji

Bhongade

et al. 2017

J. Hard Tissue Biology.

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“…[44][45][46] Moreover, inflamed sites in patients with periodontitis (G-AgP and CP) and gingivitis had higher GCF volumes compared to healthy ones, which reflects the severity of gingival inflammation in diseased groups. 44,46,47 Moreover, GCF volume, which is the indicative of the degree of gingivitis, 46 was higher in gingivitis group compared to periodontitis groups.…”

Section: Discussionmentioning

confidence: 90%

“…33,53 Studies showed low production of these novel molecules by inflammatory cells. 15,16,24,47 IL-33 is inactivated by apoptotic caspases, which results in dampening of proinflammatory properties of IL-33. 27,29,54 Moreover, IL-33 decreases inflammation opposite of the other pro-inflammatory molecules and act more as an immunoregulatory cytokine.…”

Section: Discussionmentioning

confidence: 99%

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Kursunlu

Öztürk

Han

et al. 2015

Archives of Oral Biology

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“…The progression of periodontal disease is site-specific [1], and increased numbers of lymphocytes, neutrophils and macrophages are recognized in early lesions [2][3][4]. Gingival crevicular fluid (GCF) flow also increases during gingival inflammation [5,6].…”

Section: Introductionmentioning

confidence: 99%

Correlations between pentraxin 3 or cytokine levels in gingival crevicular fluid and clinical parameters of chronic periodontitis

Fujita

Sekino

et al. 2011

Odontology

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The gingival crevicular fluid (GCF) contains various biomarkers, such as interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α), and IL-10, among others. These cytokines have been reported to correlate with gingival inflammation and periodontal status. Therefore, the analysis of GCF may be useful for the diagnosis of periodontal status. Pentraxin 3 (PTX3) is the first identified long pentraxin, and is released by several cell types in response to proinflammatory signals. The aim of this study was to determine the levels of IL-1β, IL-6, IL-8, TNF-α, IL-10 and PTX3 in GCF from diseased and healthy sites in patients with chronic periodontitis. Cross-sectional clinical data were obtained from 50 patients with chronic periodontitis. GCF samples were collected with paper strips from one periodontal diseased site and one periodontally healthy site per subject. The levels of IL-1β, IL-6, IL-8, IL-10 and TNF-α were determined using a multiplexed bead immunoassay, and the PTX3 level was measured using an enzyme-linked immunosorbent assay. Mean clinical parameters were significantly higher at diseased sites (P < 0.01) as compared to healthy sites, and the mean levels of PTX3, IL-1β, IL-6, IL-8, IL-10 and TNF-α were higher in diseased sites (P < 0.01) than in healthy sites. There were strong correlations between PTX3 or IL-1β and periodontal status. These results suggest that GCF PTX3 levels might be useful as a diagnostic marker for periodontal disease.

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Sulcular Exudate Flow in Gingival Inflammation

Cited by 51 publications

References 9 publications

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

Correlations between pentraxin 3 or cytokine levels in gingival crevicular fluid and clinical parameters of chronic periodontitis

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