Sulfadiazine

Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

“…Silver sulfadiazine has these properties because it is a metallodrug, which combines the antiseptic properties of bioactive silver ion 57,58 with the sulfadiazine API. 59 This association provides a new antibacterial agent having a broader spectrum of action, more recently finding new applications in coating for cardiac devices and indwelling catheters. 57 Insoluble in water, it dissolves slowly only in biological fluids.…”

“…We studied the formation of silver sulfadiazine, a topical sulfa-antibiotic used as an antiseptic in creams and ointments in the treatment of extensive skin burn and surgery. , Silver sulfadiazine is on the World’s Health Organization’s list of essential medicines because of its antibacterial properties against Gram-positive bacteria. Silver sulfadiazine has these properties because it is a metallodrug, which combines the antiseptic properties of bioactive silver ion , with the sulfadiazine API . This association provides a new antibacterial agent having a broader spectrum of action, more recently finding new applications in coating for cardiac devices and indwelling catheters .…”

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

“…There is noticeable disappearing for the symmetric SO 2 at 1149 cm −1 or red-shift for asymmetric stretching modes at 1344 cm −1 indicating the coordination of the sulfonamide oxygen to the metal ion. The intensity bands corresponding to the C = N group in the pyrazine ring at 1580,1512, and 1433 cm -1 ( Stober and DeWitte, 1982 ) shifted slightly after coordination to the metal concerning those of the free ligand, thus proving that N 4 pyridine associated with the complexation to form a hexagon ring. The assignment of the M–O and M–N stretching modes in the metal complex spectra was indicated by the low-intensity band in the ranges 742–600 cm -1 and 420–400 cm -1 , respectively.…”

“…Sulfonamide is a well-known antibacterial compound that has been in use for around 50 years ( Stober and DeWitte, 1982 ). It came to prominence when Domagk et al reported that Prontosil, a sulfamidochrysoidine azo dye, was reduced to the antibiotic sulfonamide and triamine benzene in living cells ( Domagk, 1935 ), with sulfonamide being the affected part in this dye molecule.…”