Sulfamethylthiazol a Report of Its Clinical Use in Staphylococcus Septicemia With Apparent Success. Report of Animal Experiments

Carroll, Grayson; Kappel, Louis; Jones, Lloyd; Gallagher, Fred W.; DiRocco, Francis W.

doi:10.1097/00007611-194001000-00023

Southern Medical Journal

1940

DOI: 10.1097/00007611-194001000-00023

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Sulfamethylthiazol a Report of Its Clinical Use in Staphylococcus Septicemia With Apparent Success. Report of Animal Experiments

Grayson Carroll¹,

Louis Kappel²,

Lloyd Jones³

et al.

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1940

1943

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Cited by 6 publications

(2 citation statements)

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“…Fitch4 obtained noteworthy results in a case of epidural abscess with septicemia and pyemia due to Staphylococcus aureus. Another case of staphylococcal septicemia, with excellent end results following the use of sulfamethylthiazole, is reported by Carroll et al 5 In a study of the literature one is immediately aware of the many toxic effects of these drugs.…”

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Staphylococcal Tracheobronchitis Treated with Sulfamethylthiazole and Sulfathiazole

Shulman¹

1941

N Engl J Med

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I want to emphasize again the point Dr. Churchill brought out about the psychologic handicap to the surgeon in the cases in which one has the typical bone picture but not the typical blood chemical findings. After one has searched for two hours unsuccessfully, in an atypical case, there is a doubt in one's mind whether to go on and subject the patient to any more search.Dr. Lahey called me the day before yesterday to say he was sorry he could not come to discuss the paper. He told me that he had just operated on a patient who, he was absolutely convinced, had a parathyroid adenoma, but that he had failed to find the tumor. Previously three excellent surgeons had explored the neck without success. This emphasizes the fact that it is an extremely difficult thing to find the parathyroid glands, even when one is positive that a tumor is present.EACH of the recent developments in the field of chemotherapy has been followed by a flood of confusing reports and claims. Sulfamethylthiazole and sulfathiazole have been no exception. A survey of the literature shows consistently good results obtained in staphylococcal infections.Bactériologie experiments conducted by Rake and McKee1 have shown sulfamethylthiazole and sulfathiazole to be particularly effective. This is further substantiated in a report by Krock and Chamberlain.2 Many different types of staphylococcal infections have been successfully treated with these drugs. Grulee and Mason3 report excellent results in cases of furunculosis in children. Fitch4 obtained noteworthy results in a case of epidural abscess with septicemia and pyemia due to Staphylococcus aureus. Another case of staphylococcal septicemia, with excellent end results following the use of sulfamethylthiazole, is reported by Carroll et al.5 In a study of the literature one is immediately aware of the many toxic effects of these drugs.Pepper and Horack6 report the formation of concretions in the renal tubules following sulfathiazole therapy. Knoll and Cooper7 also report clinical urolithiasis due to sulfathiazole. Haviland and Long8 report conjunctival and scierai reactions in the course of such therapy. Further study of these reports reveals that the aged are more susceptible to these toxic effects than patients in the younger age groups.

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confidence: 96%

Staphylococcal Tracheobronchitis Treated with Sulfamethylthiazole and Sulfathiazole

Shulman¹

1941

N Engl J Med

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“…Hamburger and Ruegsegger7 have described 12 cases, and Rammelkamp and Keefer 8 have reported 7 cases of staphylococcemia treated with these drugs. Others who have reported small series of cases of staphylococcic septicemia treated with the sulfonamides have been Thornhill, Swart and Reel, 9 Goldberg and Sachs,10 Weisman and Russell,11 Carroll and his associates 12 and Herrell and Brown.13 The chemotherapy of pneumococcic septicemia has been described by Dyke,14 and many such cases were included in the comprehensive report on the treatment of pneumococcic infections in children by Barnett, Hart¬ mann and Perley. 15 No article has been devoted solely to streptococcemia but individual case reports have been plentiful in various articles16 and in the sym¬ posium on the subject which appeared in the Journal of Pediatarics}1…”

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confidence: 99%

Chemotherapy in Childhood Sepsis

Kanof¹,

Leber²,

Krämer³

1943

JAMA

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weeks returned with a positive blood test and were subsequently treated for early syphilis. Of these 2 patients 1 had had a negative smear and negative skin test but was repeatedly negative on dark field examination and clinically was considered to have an early chancroidal ulcer. The second patient gave nega¬ tive smear and positive skin tests and also healed rapidly with sulfathiazole therapy. The diagnosis of chancroid in these 2 cases is open to question despite the fact that the lesions healed without antisyphilitic treatment. SUMMARY 1. The ratio of colored to white soldiers having Ducrey infection is much higher than the similar ratios for syphilis and gonorrhea.2. The diagnosis of chancroid is aided by reliable procedures of smear and skin test.3. Primary syphilis must be carefully differentiated from chancroid by multiple dark field examinations.4. In our experience, prophylaxis by army routine fails to protect against chancroid as well as it does against syphilis and gonorrhea. 5. Treatment with sulfathiazole in 4 Gm. daily divided doses for seven days is reliable and free of dangerous complications. CHEMOTHERAPY IN CHILDHOOD SEPSISThe literature of the past five years has been rich in papers describing all phases of sulfonamide therapy. The pharmacology of these compounds has been ably reviewed by Marshall1 and by Goodman and Gilman.2 Long and his associates3 have thoroughly described the clinical uses and toxic manifestations. In the pediatric literature, Silverman4 has contributed a critical review of the subject and Bigler and Haralambie 5 have published an exhaustive article particularly excellent for its historic and pharmacologic background.

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Chemotherapy of Bacterial Infections

Ganapathi

1940

Proc. Indian Acad. Sci.

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Sulfamethylthiazol a Report of Its Clinical Use in Staphylococcus Septicemia With Apparent Success. Report of Animal Experiments

Cited by 6 publications

References 0 publications

Staphylococcal Tracheobronchitis Treated with Sulfamethylthiazole and Sulfathiazole

Staphylococcal Tracheobronchitis Treated with Sulfamethylthiazole and Sulfathiazole

Chemotherapy in Childhood Sepsis

Chemotherapy of Bacterial Infections

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