Sulfanilamidoquinazolines

Abstract

A long-acting sulfanilamide, 2-methoxy-4-suIfanilamidoquinazoline (III), was prepared1 in low yield from 2,4-dimethoxyquinazoIine (I) and sodium sulfanilamide (II) using 2-methoxy ethanol as the reaction

Design, synthesis and cytotoxic evaluation of novel imidazolone fused quinazolinone derivatives

“…Anilinoquinazolines in particular are potent inhibitors of growth factor receptor tyrosine kinase (GFRTK) and have found clinical applications in epidermal and vascular endothelial GFR targets (Grunwald and Hidalgo, 2003). Quinazolinone heterocycles possess diverse pharmacological activities including antimycobacterial (Karel et al, 2001) antifungal (Sawhney et al, 1980) antimalarial (Martin et al, 1964), antihypertensive (Dienei et al,1973), antihistaminic (Alagarsamy et al, 2005(Alagarsamy et al, , 2006, local anesthetic (Chandrasekhar et al,1986) anti-Parkinson (Naithani et al, 1989), antiviral (Alagarsamy et al,2004), and thymidylate synthase inhibitory activities (Hennequin et al,1996). The simple and condensed quinazolinones are also known to exhibit analgesic (Alagarsamy and Murugesan, 2007), anti-inflammatory (Ravishankar et al, 1984) and anticonvulsant activities (Hori et al,1990).…”

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

“…Quinazoline nucleus is one of fused heterocyclic ring systems that possesses a wide array of biological activities. These pharmacological activities include DNA binding 4 , antitumor [5][6][7] , benzodiazepine and GABA receptor ligand activity 8 , antiviral 9,10 , antibacterial 11 , antituberculosis 12,13 and cellular phosphorylation and tyrosine kinase inhibition 14 . Many marketed drugs comprise quinazoline nucleus in their structures such as; , treatment of lupus 25 , treatment of neurodegenerative diseases 26 , antitubercular 27,28 , antiprotozoal 29,30 and anticancer 31,32 .…”

Agar: a novel, efficient, and biodegradable catalyst for the one-pot three-component and green synthesis of 2,3-dihydroquinazolin-4(1H)-one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives

“…Dihydroquinazolin-4(1H)-ones constitute an important class of heterocyclic compounds that exhibit a wide spectrum of biological and physiological activities and pharmacological properties [4,5], such as anticancer, antidiuretic, anticonvulsant, antibacterial, antifungal activity [6], and mono-amine oxidase inhibition, and are also used as 5-hydroxytryptamine (5-HT) receptor ligands [7]. Recently, Lindsley and coworkers observed the metabotropic glutamate receptor (mGluR) properties of this class of compounds [8].…”