Abstract:A thorough understanding of the pathological process underlying hypertensioninduced cardiac remodelling may help in prevention and treatment of heart failure.Angiotensin II (AngII) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production. Sulfasalazine (SASP) has evident anti-inflammatory effects and pharmacological functions on autoimmune disease. The roles of SASP in the cardiac remodelling remain unkno… Show more
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