Sulfate groups position determines the ionic selectivity and syneresis properties of carrageenan systems

Elmarhoum, Said; Mathieu, Sophie; Ako, Komla; Helbert, William

doi:10.1016/j.carbpol.2022.120166

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…Carrageenan (kappa) as a linear polysaccharide is composed of D-galactose and 3, 6-dehydrated D-galactose with one sulfate groups per repeating disaccharide [ 20 ]. The kC solution (≥1%) can spontaneously form a gel at room temperature after heating at 70 °C for 20 min.…”

Section: Introductionmentioning

confidence: 99%

Carrageenan-Based Pickering Emulsion Gels Stabilized by Xanthan Gum/Lysozyme Nanoparticle: Microstructure, Rheological, and Texture Perspective

Xiong

Sun

Niu

et al. 2022

Foods

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In this study, Pickering emulsion gels were prepared by the self-gel method based on kappa carrageenan (kC). The effects of particle stabilizers and polysaccharide concentrations on the microstructure, rheological characteristics, and texture of Pickering emulsion gels stabilized by xanthan gum/lysozyme nanoparticles (XG/Ly NPs) with kC were discussed. The viscoelasticity of Pickering emulsion gels increased significantly with the increase of kC and XG/Ly NPs. The results of temperature sweep showed that the gel formation mainly depended on the kC addition. The XG/Ly NPs addition could accelerate the formation of Pickering emulsion gels and increase its melting temperature (Tmelt), which is helpful to improve the thermal stability of emulsion gels. Cryo-scanning electron microscope (Cryo-SEM) images revealed that Pickering emulsion gel has a porous network structure, and the oil droplets were well wrapped in the pores. The hardness increased significantly with the increase of XG/Ly NPs and kC. In particular, the Pickering emulsion gel hardness was up to 2.9 Newton (N) when the concentration of kC and XG/Ly NPs were 2%. The results showed that self-gelling polysaccharides, such as kC, could construct and regulate the structure and characteristics of Pickering emulsion gel. This study provides theoretical support for potential new applications of emulsion gels as functional colloids and delivery systems in the food industry.

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Section: Introductionmentioning

confidence: 99%

Carrageenan-Based Pickering Emulsion Gels Stabilized by Xanthan Gum/Lysozyme Nanoparticle: Microstructure, Rheological, and Texture Perspective

Xiong

Sun

Niu

et al. 2022

Foods

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“…The specific affinity to tumor cells makes carrageenan a matter of concern for the targeted delivery with active drug loading with a synergistic effect [10,11] . Carrageenan has a sulfate group with the cations, which plays a very important role in the physicochemical properties, mostly carrageenan found with potassium ions [12,13] …”

Section: Introductionmentioning

confidence: 99%

“…[10,11] Carrageenan has a sulfate group with the cations, which plays a very important role in the physicochemical properties, mostly carrageenan found with potassium ions. [12,13] The gelling property and hydrophilicity are highly dependent on the ion present, [14] as it is well established that iota carrageenan gives better gel with Ca 2 + [15] and kappa carrageenan gives with K + . [16] The galactose-based heterocycle possesses various biological concerns, but the binding of the core to tumor cells is found to be an area of concern.…”

Section: Introductionmentioning

confidence: 99%

Modulating Ionic Linkages in the Heterocyclic Sulfated Polysaccharide Carrageenan for Enhanced Selectivity Against Amelanotic Melanoma Cells

Bhatt,

Kailkhura,

Shukla

et al. 2024

ChemistrySelect

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The present research is the use of Heterocyclic sulfated polysaccharides, exemplified by carrageenan, with the high selective anti‐cancer against melanoma cancer. This study focuses on optimizing the ionic linkage of carrageenan to enhance its selectivity and activity against skin cancer cells with the help of cell line assays and in‐silico studies. The cytotoxicity and selectivity of the optimized derivatives were assessed in‐vitro against skin cancer cells and normal skin cells. The barium‐linked carrageenan demonstrated significantly increased selectivity against skin cancer cells with a selectivity index of 45, however, the reference drug was found with a selectivity index of 23. The selectivity of the compound 3 (Ba ion linked) was analysed through the ion dissociation energy and found that the more energy is require to dissoxiate in the ion, which signifiacnlty absorbs inside the cell because of non‐ionic form. The selectivity sequence of K+<Ca2+<Ba2+ as a targeted anti‐cancer agent. The present research unfold the importance of ion linkage of chromophore, to get the more active and selective compounds, which will be a path to get the ion activity relationship of various drugs without interfering the chromophore. The findings suggest a promising avenue for the development of targeted therapies with the change of ions, emphasizing the potential of heterocyclic sulfated polysaccharides in the field of cancer treatment with enhanced tuning of selectivity. The further scope is the gel formation of the Ba2+ carrageenan which will be the first API (Active Pharmaceuitical Ingredients) based formulation for skin cancer.

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“…Due to multiple negative charges, carrageenan macromolecules interact strongly with inorganic and organic cations. The texture and properties of carrageenan gels depend on the Na, K, Mg and Ca cations present [25][26][27][28][29]. Cationic dyes form ionic associates with carrageenan polyanions, resulting in hydrophobic aggregation and spectral changes [30].…”

Section: Introductionmentioning

confidence: 99%

Coagulation of Hydrophobic Ionic Associates of Cetyltrimethylammonium Bromide and Carrageenan

Shyichuk,

Ziółkowska,

Szulc

2023

Molecules

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In aqueous solutions, cetyltrimethylammonium cations bind to carrageenan polyanions, and the resulting ionic associates form macroscopic aggregates due to hydrophobic interaction. At certain ratios of cetyltrimethylammonium to carrageenan, the resulting colloidal particles auto-flocculate. According to visual observations, the ratio ranges from 1 to 3 mmol/g; otherwise the suspensions are stable. By measuring the sedimentation rate and particle size distribution, the most extensive flocculation was found to be from 1.7 to 2.3 mmol/g. The ratio corresponding to the fastest auto-flocculation was precisely determined by titrating the reagents with small increments and recording the turbidity. The turbidimetric titration plots contain distinct break points corresponding to the most extensive flocculation. These break points occur at the same ratio of carrageenan to cetyltrimethylammonium over a wide range of reagent concentrations. The precise values of the critical ratio were found to be 1.78 and 1.53 mmol/g, respectively, during the titration of cetyltrimethylammonium with carrageenan and vice versa. The number of anionic sulfate groups in carrageenan was measured by ICP OES and found to be 1.35 mmol/g. This value is consistent with the critical ratio of the auto-flocculation.

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Sulfate groups position determines the ionic selectivity and syneresis properties of carrageenan systems

Cited by 11 publications

References 45 publications

Carrageenan-Based Pickering Emulsion Gels Stabilized by Xanthan Gum/Lysozyme Nanoparticle: Microstructure, Rheological, and Texture Perspective

Carrageenan-Based Pickering Emulsion Gels Stabilized by Xanthan Gum/Lysozyme Nanoparticle: Microstructure, Rheological, and Texture Perspective

Modulating Ionic Linkages in the Heterocyclic Sulfated Polysaccharide Carrageenan for Enhanced Selectivity Against Amelanotic Melanoma Cells

Coagulation of Hydrophobic Ionic Associates of Cetyltrimethylammonium Bromide and Carrageenan

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