Sulfated hyaluronic acid/collagen-based biomimetic hybrid nanofiber skin for diabetic wound healing: Development and preliminary evaluation

Zhou, Yuanmeng; Jia, Weibin; Bi, Jiexue; Liu, Meng; Liu, Liling; Zhou, Hang; Gu, Guofeng; Chen, Zonggang

doi:10.1016/j.carbpol.2024.122025

Carbohydrate Polymers

2024

DOI: 10.1016/j.carbpol.2024.122025

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Sulfated hyaluronic acid/collagen-based biomimetic hybrid nanofiber skin for diabetic wound healing: Development and preliminary evaluation

Yuanmeng Zhou,

Weibin Jia,

Jiexue Bi

et al.

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Cited by 7 publications

References 33 publications

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Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics

Jia,

Li,

Zou

et al. 2024

Adv Healthcare Materials

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The major drawback of conventional chemotherapeutic treatment is the non‐specificity or inability to ascertain and target cancerous cells directly. In this study, an active targeting strategy that is poised to carry the anticancer agents to the desired sites for therapeutic action while avoiding toxicity to normal organs is provided. The active targeting of delivery vehicles is achieved by ligand‐receptor interactions, in particular the specific binding between hyaluronic acid oligosaccharides (oHAs) and CD44 receptors. This study first prepares oHAs by the size‐exclusion chromatography and utilizes them to decorate chitosan (CTS) as basic materials (oHAs‐CTS) for drug delivery, then fabricates oHAs‐CTS into micro/nanoscale carriers to encapsulate agents for cancer chemotherapy. The oHAs‐CTS micro/nanocarriers exhibit high drug encapsulation efficiency (58–87%), and the drug releases present a sustained behavior. Notably, oHAs‐CTS delivery vehicles display an enhanced active targeting toward cancers and alleviate the cytotoxic effects on normal cells. Additionally, in vivo results show that drug‐laden oHAs‐CTS nanocarriers demonstrate a significant inhibitory effect on 4 T1 tumors without any toxicity to the major organs. Taken together, the findings highlight the potential of oHAs‐CTS micro/nanospheres as delivery vehicles with enhanced active targeted capability toward cancers and minimized adverse effects of chemotherapeutic agents for cancer treatment.

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Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics

Jia,

Li,

Zou

et al. 2024

Adv Healthcare Materials

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Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review

Senobari,

Abolmaali,

Farahavr

et al. 2024

International Journal of Biological Macromolecules

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Natural polymer nanofiber dressings for effective management of chronic diabetic wounds: A comprehensive review

Zhou,

Li,

Zeng

et al. 2024

International Journal of Biological Macromolecules

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Sulfated hyaluronic acid/collagen-based biomimetic hybrid nanofiber skin for diabetic wound healing: Development and preliminary evaluation

Cited by 7 publications

References 33 publications

Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics

Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics

Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review

Natural polymer nanofiber dressings for effective management of chronic diabetic wounds: A comprehensive review

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