Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages

Yu, Yuanman; Dai, Kai; Gao, Zehua; Tang, Wei; Shen, Tong; Yuan, Yuan; Wang, Jing; Liu, Changsheng

doi:10.1126/sciadv.abd8217

Cited by 86 publications

(63 citation statements)

References 41 publications

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“…It was reported that the inflammation at the early stage of wound repair benefited the recruitment of inflammatory cells, biochemical factors, and bone progenitor cells 38 . Hence, higher BMP-2 and VEGF secretion induced by HCLS could be attributed to polarized M2 phenotype macrophages 39 , 40 .…”

Section: Resultsmentioning

confidence: 94%

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An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

Liu

et al. 2022

Nat Commun

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Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid chelating Ca2+ of the microhydroxyapatite surface and bonding type I collagen to highly simulate the natural bony matrix. It presents a good mechanical match and interface integration by appropriate calcium chelation, and responds to external stress by flexible deformation. Meanwhile, the appropriate matrix microenvironment regulates macrophage M2 polarization and recruits endogenous stem cells. This scaffold promotes the proliferation and osteogenic differentiation of BMSCs in vitro, as well as significant ectopic mineralization and angiogenesis. Transcriptome analysis confirmed the upregulation of relevant genes and signalling pathways was associated with M2 macrophage activation, endogenous stem cell recruitment, angiogenesis and osteogenesis. Together, the scaffold realized 97 and 72% bone cover areas after 12 weeks in cranial defect models of rabbit (Φ = 9 mm) and beagle dog (Φ = 15 mm), respectively.

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Section: Resultsmentioning

confidence: 94%

“…Implantable biomaterials with favorable immune responses can guide successful osteogenesis and angiogenesis 40 , 62 . Thus, the in vitro and in vivo immune responses of HCLS and DCLS were evaluated.…”

Section: Discussionmentioning

confidence: 99%

An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

Liu

et al. 2022

Nat Commun

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“…With highly concentrated negatively sulfated groups, heparin interacts with many proteins to regulate physiological and pathological processes including inflammation, anticoagulation, lipid metabolism, angiogenesis, and neural regeneration [ 151 ]. Liu’s group developed a heparin-like semisynthetic sulfated chitosan (SCS) to promote angiogenesis and treat ischemic disease [ 152 ]. SCS is a highly bioactive biomaterial, which can mediate macrophage polarization to M2 through the STAT6 signalling pathway.…”

Section: Biomaterials For Immunoregulationmentioning

confidence: 99%

Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine

Shi

et al. 2022

Science and Technology of Advanced Materials

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Nanoarchitectonics has emerged as a post-nanotechnology concept. As one of the applications of nanoarchitectonics, this review paper discusses the control of stem cell fate and function as an important issue. For hybrid nanoarchitectonics involving living cells, it is crucial to understand how biomaterials and their nanoarchitected structures regulate behaviours and fates of stem cells. In this review, biomaterials for the regulation of stem cell fate are firstly discussed. Besides multipotent differentiation, immunomodulation is an important biological function of mesenchymal stem cells (MSCs). MSCs can modulate immune cells to treat multiple immune- and inflammation-mediated diseases. The following sections summarize the recent advances of the regulation of the immunomodulatory functions of MSCs by biophysical signals. In the third part, we discussed how biomaterials direct the self-organization of pluripotent stem cells for organoid. Bioactive materials are constructed which mimic the biophysical cues of in vivo microenvironment such as elasticity, viscoelasticity, biodegradation, fluidity, topography, cell geometry, and etc. Stem cells interpret these biophysical cues by different cytoskeletal forces. The different cytoskeletal forces lead to substantial transcription and protein expression, which affect stem cell fate and function. Regulations of stem cells could not be utilized only for tissue repair and regenerative medicine but also potentially for production of advanced materials systems. Materials nanoarchitectonics with integration of stem cells and related biological substances would have high impacts in science and technology of advanced materials.

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“…Zhang et al 50 found that “Shexiang Baoxin Pill” (SBP) could activate macrophages to produce pro‐angiogenic factors and promote ECs' proliferation by activating the PI3K/Akt and MAPK/Erk1/2 signaling pathways. Yu et al 51 discovered that a semisynthetic sulfated chitosan could promote the functions of VEGF released by M2 macrophages via the VEGF‐VEGFR2 signaling pathway. Liu et al 52 studied the process of macrophage‐related angiogenesis in hepatopulmonary syndrome.…”

Section: Macrophages Improve Fat Survival By Promoting Neovasculariza...mentioning

confidence: 99%

Effects of macrophage regulation on fat grafting survival: Improvement, mechanisms, and potential application—A review

Chen

Liu

Cao

et al. 2021

J of Cosmetic Dermatology

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Background Autologous fat grafting has become a popular tool in plastic surgery to solve soft tissue defects and achieve skin rejuvenation, but the volume loss after transplantation remains a disturbing problem. In recent years, some new strategies have improved the outcome to some extent, but the fat graft retention is still far from ideal, so there remains a wide development prospect in this field. Macrophages are closely related to the local microenvironment and tissue regeneration, and their role in fat grafting has been increasingly highlighted. Aims This article was aimed to review the efficacy, possible mechanisms, and potential application of macrophage regulation on fat grafting, as well as concerns and future perspectives of this filed. Methods A retrospective review of the published data was conducted. Results Most studies indicated that up‐regulating M2 macrophages during fat grafting would improve fat retention via promoting neovascularization. M2 macrophages could secrete several pro‐angiogenic factors, accelerate extracellular matrix (ECM) remodeling, and directly function on endothelial cells to encourage vascular expansion. In addition, macrophages could influence the proliferation, apoptosis, and adipogenic differentiation of preadipocytes. Conclusions During autologous fat grafting, appropriately regulating macrophages may become a promising method to increase fat retention. Nevertheless, the M2 macrophage polarizing agents, treatment opportunity, and contraindications require further discussion. We hope our work could promote more in‐depth studies in this field, and we are looking forward to a standard procedure for the macrophage therapy in clinical practice.

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Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages

Cited by 86 publications

References 41 publications

An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine

Effects of macrophage regulation on fat grafting survival: Improvement, mechanisms, and potential application—A review

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