Sulfated polysaccharides derived from marine microalgae, Synechococcus sp. VDW, inhibit the human colon cancer cell line Caco-2 by promoting cell apoptosis via the JNK and p38 MAPK signaling pathway

Srimongkol, Piroonporn; Songserm, Pajareeya; Kuptawach, Kittisak; Puthong, Songchan; Sangtanoo, Papassara; Thitiprasert, Sitanan; Thongchul, Nuttha; Phunpruch, Saranya; Karnchanatat, Aphichart

doi:10.1016/j.algal.2022.102919

Cited by 13 publications

(7 citation statements)

References 51 publications

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“…VDW, were tested at various concentrations (ranging from 7.81 μg/mL to 1000 μg/mL) and incubated for 72 h. The findings showed that when MMPS concentrations remained below 125 μg/mL, there was no observed cytotoxic effect. However, when concentrations were increased to 250, 500, and 1000 μg/mL, there were corresponding reductions in viable cell numbers by 11 %, 41 %, and 75 %, respectively [ 28 ]. Lui et al [ 73 ], it was explained that the concentration of exopolysaccharide (EPS) and sulfated EPS may play a role in governing cell viability and oxidative stress in Caco-2 cells.…”

Section: Resultsmentioning

confidence: 99%

“…The MW of SGP was assessed through a modified approach based on the work of Srimongkol et al [ 28 ], using GPC (gel-permeation chromatography) (Waters, USA) with a 2414 RI detector and four PWXL columns of TSK-gel (TOSOH, Japan) connected in series. The purified SGP (2 mg/mL) was initially filtered via 0.2 μm nylon filter, whereupon the sample solutions (20 μL) and standards were independently injected prior to elution using HPLC grade water at a flow rate of 1 mL/min at a steady 40 °C.…”

Section: Methodsmentioning

confidence: 99%

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Sulfated polysaccharides from Caulerpa lentillifera: Optimizing the process of extraction, structural characteristics, antioxidant capabilities, and anti-glycation properties

Tesvichian,

Sangtanoo,

Srimongkol

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Sulfated polysaccharides from Caulerpa lentillifera: Optimizing the process of extraction, structural characteristics, antioxidant capabilities, and anti-glycation properties

Tesvichian,

Sangtanoo,

Srimongkol

et al. 2024

Heliyon

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“…The use of marine polysaccharides in various industries is gaining increasing attention due to their sustainable nature and the need for eco-friendlier materials. , The development of new technologies and extraction methods has made it easier to obtain high-quality marine polysaccharides in larger quantities, which has led to an increase in their use in various applications. , …”

Section: Introductionmentioning

confidence: 99%

“…19,20 The use of marine polysaccharides in various industries is gaining increasing attention due to their sustainable nature and the need for eco-friendlier materials. 21,22 The development of new technologies and extraction methods has made it easier to obtain high-quality marine polysaccharides in larger quantities, which has led to an increase in their use in various applications. 23,24 The primary benefit of utilizing marine polysaccharide-based edible food packaging materials is to safeguard the food's quality, extend its shelf life, and enhance the functional properties, financial advantages, and ecological sustainability of the packaging, as indicated by source.…”

Section: Introductionmentioning

confidence: 99%

Current Status of Marine Animal Derived Polysaccharides in Sustainable Food Packaging

Sarkar,

Manna,

Das

et al. 2023

ACS Food Sci. Technol.

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The dominant use of synthetic plastic derivatives is one of the major concerns across the world. The irrational use of plastic not only causes environmental pollution but also is reported to cause several health hazards. This has led researchers to develop biodegradable packaging materials derived from biomaterials. Polysaccharides are abundantly available biopolymers with excellent biodegradability. Marine animals are a vast source of obtained polysaccharides, including chitosan, hyaluronic acid, and chondroitin sulfate. The edible nature of the extracted marine-animal-derived polysaccharides makes it a useful alternative for synthetic derivatives in the food packaging industry. In addition, the antimicrobial and antioxidant behavior of marine-animalderived polysaccharides has favored its emergence as a packaging material. The film forming, protective, and excellent barrier property has encouraged the scientists to investigate them as food packaging materials. The easy modifiability of these polysaccharides can improve the film forming ability. This Article focuses on the recent advancements in marine animal derived polysaccharides in sustainable food packaging applications.

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“…It has been reported that marine Synechococcus sp. contain multiple biologically active compounds, which include antibacterial, antifungal, antiviral, and cancer-fighting compounds ( Martins et al, 2008 ; Costa et al, 2013 ; do Amaral et al, 2020 ; Srimongkol et al, 2023 ). Numbers of studies have indicated that they also have antioxidant and anti-inflammatory potential ( de Morais et al, 2015 ; Gómez et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

Xie,

Chen,

et al. 2023

Front. Pharmacol.

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In recent years, the Alzheimer’s disease (AD) epidemic has become one of the largest global healthcare crises. Besides, the available systemic therapies for AD are still inadequate. Due to the insufficient therapeutic options, new treatment strategies are urgently needed to achieve a satisfactory therapeutic effect. Marine bio-resources have been accepted as one of the most economically viable and sustainable sources with potential applications for drug discovery and development. In this study, a marine cyanobacteria–Synechococcus sp. XM-24 was selected as the object of research, to systematically investigate its therapeutic potential mechanisms for AD. The major active compounds derived from the Synechococcus sp. biomass were identified via pyrolysis-gas chromatography-mass spectrometry (GC-MS), and 22 compounds were identified in this strain. The most abundant chemical compounds was (E)-octadec-11-enoic acid, with the peak area of 30.6%. Follow by tridecanoic acid, 12-methyl- and hexadecanoic acid, with a peak area of 23.26% and 18.23%, respectively. GC-MS analysis also identified indolizine, isoquinoline, 3,4-dihydro- and Phthalazine, 1-methyl-, as well as alkene and alkane from the strain. After the chemical toxicity test, 10 compounds were finally collected to do the further analysis. Then, network pharmacology and molecular docking were adopted to systematically study the potential anti-AD mechanism of these compounds. Based on the analysis, the 10 Synechococcus-derived active compounds could interact with 128 related anti-AD targets. Among them, epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGFA) and mitogen-activated protein kinase 3 (MAPK3) were the major targets. Furthermore, the compounds N-capric acid isopropyl ester, (E)-octadec-11-enoic acid, and 2H-Pyran-2,4(3H)-dione, dihydro-6-methyl- obtained higher degrees in the compounds-intersection targets network analysis, indicating these compounds may play more important role in the process of anti-AD. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that these active compounds exert the anti-AD effects mainly through PI3K-Akt signaling pathway, neuroactive ligand-receptor interaction and ras signaling pathway. Our study identified Synechococcus-derived bioactive compounds have the potential for application to AD by targeting multiple targets and related pathways, which will provide a foundation for future research on applications of marine cyanobacteria in the functional drug industry.

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Sulfated polysaccharides derived from marine microalgae, Synechococcus sp. VDW, inhibit the human colon cancer cell line Caco-2 by promoting cell apoptosis via the JNK and p38 MAPK signaling pathway

Cited by 13 publications

References 51 publications

Sulfated polysaccharides from Caulerpa lentillifera: Optimizing the process of extraction, structural characteristics, antioxidant capabilities, and anti-glycation properties

Sulfated polysaccharides from Caulerpa lentillifera: Optimizing the process of extraction, structural characteristics, antioxidant capabilities, and anti-glycation properties

Current Status of Marine Animal Derived Polysaccharides in Sustainable Food Packaging

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

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