Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury

Qiu, Husen; Li, Jinjin; Huang, Yuandi; Shen, Chongxing; Dai, Linyong; Su, Qiaoling; Zhi, Yi; Fang, Qiang; Chen, Shi; Li, Weibing

doi:10.1088/1748-605x/acadc2

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…HA, a natural anionic polymer, is a major component of the extracellular matrix . HA binds specifically to CD44 receptors on the cell membrane .…”

Section: Resultsmentioning

confidence: 99%

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Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer

Qiu,

Wang,

Zhi

et al. 2023

ACS Appl. Mater. Interfaces

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Bladder cancer is one of the most common malignancies in the urinary system, with high risk of recurrence and progression. However, the difficulty in detecting small tumor lesions and the lack of selectivity of intravesical treatment seriously affect the prognosis of patients with bladder cancer. In the present work, a nanoparticle-based delivery system with tumor targeting, high biocompatibility, simple preparation, and the ability to synergize imaging and therapy was fabricated. Specifically, this nanosystem consisted of the core of doxorubicin (DOX)-loaded polydopamine nanoparticles (PDD NPs) and the shell of hyaluronic acid (HA)-conjugated IR780 (HA-IR780). The HA-IR780-covered PDD NPs (HR-PDD NPs) demonstrated tumor targeting and visualization both in vitro and in vivo with properties of promoted cancer cell endocytosis and lysosomal escape, efficiently delivering drugs to the target site and exerting a killing effect on tumor cells. Encouragingly, intravesical instillation of HR-PDD NPs improved drug retention in the bladder and promoted its accumulation in tumor tissue, resulting in better tumor proliferation inhibition and apoptosis in an orthotopic bladder cancer model in rats. This study provides a promising strategy for the diagnosis and therapy of bladder cancer.

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“…HA, a natural anionic polymer, is a major component of the extracellular matrix . HA binds specifically to CD44 receptors on the cell membrane .…”

Section: Resultsmentioning

confidence: 99%

“…HA, a natural anionic polymer, is a major component of the extracellular matrix. 45 HA binds specifically to CD44 receptors on the cell membrane. 39 The CD44 receptor is highly expressed in many tumors and relatively low expressed in normal tissues, which is the basis for HA targeting tumor.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer

Qiu,

Wang,

Zhi

et al. 2023

ACS Appl. Mater. Interfaces

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“…Despite the existence of extensive research studies on the utilization of hydrogel systems for intravesical drug delivery [ 58 , 59 ], the implementation of Lev@PADM in the management of bacterial cystitis presents an innovative intervention. Hydrogels possess the capacity to mitigate drug dilution and confer adhesive or floating characteristics to loaded substances, thereby prolonging the drug’s efficacy within the bladder [ 60 , 61 ]. A study documented the development of a mucoadhesive hydrogel composed of high molecular weight chitosan and β-glycerophosphate, which exhibited enhanced resistance to urine washout when evaluated ex vivo using porcine urinary bladder, thus presenting a potential treatment option for bladder cancer [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection

Yang,

et al. 2024

J Nanobiotechnol

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Bacterial cystitis, a commonly occurring urinary tract infection (UTI), is renowned for its extensive prevalence and tendency to recur. Despite the extensive utilization of levofloxacin as a conventional therapeutic approach for bacterial cystitis, its effectiveness is impeded by adverse toxic effects, drug resistance concerns, and its influence on the gut microbiota. This study introduces Lev@PADM, a hydrogel with antibacterial properties that demonstrates efficacy in the treatment of bacterial cystitis. Lev@PADM is produced by combining levofloxacin with decellularized porcine acellular dermal matrix hydrogel and exhibits remarkable biocompatibility. Lev@PADM demonstrates excellent stability as a hydrogel at body temperature, enabling direct administration to the site of infection through intravesical injection. This localized delivery route circumvents the systemic circulation of levofloxacin, resulting in a swift and substantial elevation of the antimicrobial agent’s concentration specifically at the site of infection. The in vivo experimental findings provide evidence that Lev@PADM effectively prolongs the duration of levofloxacin’s action, impedes the retention and invasion of E.coli in the urinary tract, diminishes the infiltration of innate immune cells into infected tissues, and simultaneously preserves the composition of the intestinal microbiota. These results indicate that, in comparison to the exclusive administration of levofloxacin, Lev@PADM offers notable benefits in terms of preserving the integrity of the bladder epithelial barrier and suppressing the recurrence of urinary tract infections. Graphical Abstract

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“…The hydrogel demonstrated prolonged residence time and continuous drug release for up to 10 h when tested in vivo using a rabbit acute bladder injury model . Several other hydrogels investigated for use as intravesical drug delivery systems and therapeutic bulking agents were reported as promising drug delivery systems for treating urinary bladder disorders. − …”

Section: Mucosal Tissuesmentioning

confidence: 99%

Hydrogels for Mucosal Drug Delivery

Yeruva

Yang

Doski

et al. 2023

ACS Appl. Bio Mater.

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Mucosal tissues are often a desirable site of drug action to treat disease and engage the immune system. However, systemically administered drugs suffer from limited bioavailability in mucosal tissues where technologies to enable direct, local delivery to these sites would prove useful. In this Spotlight on Applications article, we discuss hydrogels as an attractive means for local delivery of therapeutics to address a range of conditions affecting the eye, nose, oral cavity, gastrointestinal, urinary bladder, and vaginal tracts. Considering the barriers to effective mucosal delivery, we provide an overview of the key parameters in the use of hydrogels for these applications. Finally, we highlight recent work demonstrating their use for inflammatory and infectious diseases affecting these tissues.

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Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury

Cited by 7 publications

References 52 publications

Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer

Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer

Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection

Hydrogels for Mucosal Drug Delivery

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